Patents by Inventor Miles P. Hacker

Miles P. Hacker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of s-triazines for treating Apicomplexan parasitic infections
    Publication number: 20030109529
    Abstract: This invention relates to novel compositions and methods of treating humans and animals infected by Apicomplexan parasites. More specifically, the present invention relates to treating an Apicomplexan infection by administering s-triazines, such as atrazine, to an infected human or animal. The present invention also relates to pharmaceutical compositions containing therapeutically effective amounts of s-triazines, such as atrazine, useful in treating parasitic infections.
    Type: Application
    Filed: October 2, 2002
    Publication date: June 12, 2003
    Applicant: Biomes, Inc.
    Inventors: Miles P. Hacker, Greg Manske, Lori L. Shatney-Leach
  • 6,9-bis[(2-aminoethyl) amino]benzo [g]isoquinoline-5,10- dione dimaleate; an aza-anthracenedione with reduced cardiotoxicity
    Patent number: 5587382
    Abstract: In the search for novel heteroanalogs of anthracenediones, 6,9-bis[(2-aminoethyl-amino]-benzo[g]isoquinoline-5,10-dione dimaleate (BBR 2778), was selected as the most promising compound. Toxicological studies indicate that BBR 2778 is not cardiotoxic.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: December 24, 1996
    Assignee: Boehringer Mannheim Italia, SpA
    Inventors: A. Paul Krapcho, Miles P. Hacker, Ennio Cavalletti, Ferdinando C. Giuliani
  • Unsymmetrical 1,4-bis(aminoalkylamino)-anthracene-9, 10-diones and derivatives
    Patent number: 4894451
    Abstract: The disclosure describes unsymmetrical 1,4-bis-(aminoalkylamino)-anthracene-9,10-diones useful in the treatment of neoplasms. Also described is a process of preparing same starting from 1,4-dimethoxyanthracene-9,10-dione which is reacted with an aminoalkylamine. The reaction product is treated with a dialkylaminoethylamine or a N-heteroethylamine to give the unsymmetrical compound.
    Type: Grant
    Filed: July 19, 1988
    Date of Patent: January 16, 1990
    Assignee: The University of Vermont
    Inventors: A. Paul Krapcho, Miles P. Hacker, John J. Landi, Jr., J. J. McCormack, Kenneth J. Shaw
  • Bisplatinum complexes as chemotherapeutic agents
    Patent number: 4871729
    Abstract: A bis-platinum complex having the structure: ##STR1## wherein X and Y are the same or different ligands and are halide, sulphate, phosphate, nitrate, carboxylate, substituted carboxylate or dicarboxylate. B and C are the same or different and are primary or secondary amines, or pyridine type nitrogens. A is a diamine or polyamine wherein the primary amine N atoms are coordinated to the Pt atom such that platinum is present as Pt.sup.2+. The complexes are useful in the inhibition of tumors.
    Type: Grant
    Filed: January 9, 1989
    Date of Patent: October 3, 1989
    Assignee: University of Vermont and State Agricultural College
    Inventors: Nicholas Farrell, Miles P. Hacker, John J. McCormack, Sergio G. DeAlmeida
  • Bis-platinum complexes as chemotherapeutic agents
    Patent number: 4797393
    Abstract: A bis-platinum complex having the structure: ##STR1## wherein X and Y are the same or different ligands and are halide, sulphate, phosphate, nitrate, carboxylate, substituted carboxylate or dicarboxylate. B and C are the same or different and are primary or secondary amines, or pyridine type nitrogens. A is a diamine or polyamine wherein the primary amine N atoms are coordinated to the Pt atom such that platinum is present as Pt.sup.2+. The complexes are useful in the inhibition of tumors.
    Type: Grant
    Filed: July 25, 1986
    Date of Patent: January 10, 1989
    Assignee: University of Vermont and State Agricultural College
    Inventors: Nicholas Farrell, Miles P. Hacker, John J. McCormack, Sergio G. DeAlmeida
  • Diaminocyclohexane platinum complexes
    Patent number: 4758588
    Abstract: Diaminocyclohexane platinum complexes having the structural formula ##STR1## wherein: X is a monovalent anion selected from the group consisting of isoascorbate, monosaccharate, saccharate-4-lactone, shikimate, isethionate, 2-aminoethylsulfate, azetidinecarboxylate, proline, hydroxyproline, pipecolinate, cyclopropanecarboxylate, cxyclobutanecarboxylate, cyclopentanecarboxylate, cyclopentenecarboxylate, cyclohexanecarboxylate, cyclohexenecarboxylate, bicine, glycine, 2-aminoethanesulfonate, 2-chloroethanesulfonate andY is a divalent anion selected from the group consisting of iminodiacetate, isocitratelactone, furanedicarboxylate, cyclopropane-1,1-dicarboxylate, isocitratomonoethylester, N-methyliminodiacetate, N-(2-hydroxyethyl)-iminodiacetate, N-benzyliminodiacetate, N-phenyliminodiacetate, N-(2-acetamido)-iminodiacetate, cyclohexane-1,1-diacetate, trans-1,2-cyclopropanedicarboxylate, trans-1,2-cyclobutanedicarboxylate, trans-1,2-cyclopentanedicarboxylate and trans-1,2-cyclohexanedicarboxylate and their use
    Type: Grant
    Filed: February 17, 1987
    Date of Patent: July 19, 1988
    Assignee: Research Corporation Technologies
    Inventors: David B. Brown, deceased, Abdul R. Khokhar, Miles P. Hacker, John J. McCormack
  • Diaminocyclohexane platinum complexes
    Patent number: 4661516
    Abstract: Diaminocyclohexane platinum complexes having the structural formula ##STR1## wherein: X is a monovalent anion selected from the group consisting of isoascorbate, monosaccharate, saccharate-4-lactone, shikimate, isethionate, 2-aminoethylsulfate, azetidinecarboxylate, proline, hydroxyproline, pipecolinate, cyclopropanecarboxylate, cyclobutanecarboxylate, cyclopentanecarboxylate, cyclopentenecarboxylate, cyclohexanecarboxylate, cyclohexenecarboxylate, bicine, glycine, 2-aminoethanesulfonate, 2-chloroethanesulfonate andY is a divalent anion selected from the group consisting of iminodiacetate, isocitratelactone, furanedicarboxylate, cyclopropane-1,1-dicarboxylate, isocitratomonoethylester, N-methyliminodiacetate, N-(2-hydroxyethyl)-iminodiacetate, N-benzyliminodiacetate, N-phenyliminodiacetate, N-(2-acetamido)iminodiacetate, cyclohexane-1,1-diacetate, trans-1,2-cyclopropanedicarboxylate, trans-1,2-cyclobutanedicarboxylate, trans-1,2-cyclopentanedicarboxylate and trans-1,2-cyclohexanedicarboxylateand their use in
    Type: Grant
    Filed: April 15, 1985
    Date of Patent: April 28, 1987
    Assignee: Research Corporation
    Inventors: David B. Brown, deceased, Abdul R. Khokhar, Miles P. Hacker, John J. McCormack