Patents by Inventor Milind CHOUKEKAR

Milind CHOUKEKAR has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • AN IMPROVED PROCESS FOR THE PREPARATION OF APREPITANT
    Publication number: 20160031867
    Abstract: The present invention provides a process for the preparation of 5-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazole-3-one (Aprepitant) comprising condensation of 2-(R)-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(S)-(4-fluorophenyl)morpholine hydrochloride salt with 2-(2-chloro-1-iminoethyl)hydrazinecarboxylic acid methyl ester to obtain the reaction mixture containing 2-[2-[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]-1-iminoethyl]hydrazinecarboxylic acid methyl ester, which is in-situ cyclized in the presence of dimethylsulfoxide and a polar protic solvent at a low temperature to yield aprepitant having purity ?99.5%.
    Type: Application
    Filed: February 22, 2013
    Publication date: February 4, 2016
    Applicant: PIRAMAL ENTERPRISES LIMITED
    Inventors: Prashant LADKAT, Ganesh WAGH, Ashutosh JAGTAP, Mita ROY, Sivaramakrishnan HARIHARAN, Milind CHOUKEKAR