Patents by Inventor Milka Yanachkova

Milka Yanachkova has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds and methods for peptide synthesis
    Publication number: 20090036650
    Abstract: A backbone nitrogen modifying group can prevent aggregation of peptides during peptide synthesis. The modifying group can promote aqueous solubility of the peptides, and be compatible with solid phase peptide synthesis. Methods for making peptides are also described.
    Type: Application
    Filed: March 24, 2006
    Publication date: February 5, 2009
    Inventors: Julio Herman Cuervo, Milka Yanachkova, Russell C. Petter, Thomas F. Durand-Reville, Jose Carlos Jimenez-Garcia
  • Acyclovir diester derivatives
    Publication number: 20010012893
    Abstract: Disclosed are novel prodrugs represented by the following structural formula: 1
    Type: Application
    Filed: December 6, 2000
    Publication date: August 9, 2001
    Applicant: Drug Innovation & Design, Inc.
    Inventors: Arnold Glazier, Milka Yanachkova, Ivan Yanachkov
  • Acyclovir diester derivatives
    Patent number: 6214811
    Abstract: Disclosed are novel prodrugs represented by the following structural formula; Z is oxygen or sulfur; Y is, together with a hydroxy group, acyclovir or an analog of acyclovir; A is a substituted benzyl group with one or more protected hydroxy or protected amine groups in the ortho or para positions, relative to the phosphate ester, which can be converted in vivo to a hydroxy or amino group. Also disclosed is a method of treating a viral infection in an individual or animal. The method comprises administering to the individual or animal a therapeutically effective amount of a prodrug represented by structural formula shown above.
    Type: Grant
    Filed: February 28, 2000
    Date of Patent: April 10, 2001
    Assignee: Drug Innovation & Design, Inc.
    Inventors: Arnold Glazier, Milka Yanachkova, Ivan Yanachkov
  • Methods of preparing acyclovir prodrugs
    Patent number: 6180790
    Abstract: Disclosed are novel prodrugs represented by the following structural formula: Z is oxygen or sulfur; Y is, together with a hydroxy group, acyclovir or an analog of acyclovir; A is a substituted benzyl group with one or more protected hydroxy or protected amine groups in the ortho or para positions, relative to the phosphate ester, which can be converted in vivo to a hydroxy or amino group. Also disclosed is a method of treating a viral infection in an individual or animal. The method comprises administering to the individual or animal a therapeutically effective amount of a prodrug represented by structural formula shown above.
    Type: Grant
    Filed: December 10, 1999
    Date of Patent: January 30, 2001
    Assignee: Drug Innovation and Design, Inc.
    Inventors: Arnold Glazier, Milka Yanachkova, Ivan Yanachkov
  • Acyclovir diester derivatives
    Patent number: 6031096
    Abstract: Disclosed are novel prodrugs represented by the following structural formula: ##STR1## Z is oxygen or sulfur; Y is, together with a hydroxy group, acyclovir or an analog of acyclovir; A is a substituted benzyl group with one or more protected hydroxy or protected amine groups in the ortho or para positions, relative to the phosphate ester, which can be converted in vivo to a hydroxy or amino group. Also disclosed is a method of treating a viral infection in an individual or animal. The method comprises administering to the individual or animal a therapeutically effective amount of a prodrug represented by structural formula shown above.
    Type: Grant
    Filed: May 15, 1998
    Date of Patent: February 29, 2000
    Assignee: Drug Innovation & Design, Inc.
    Inventors: Arnold Glazier, Milka Yanachkova, Ivan Yanachkov