Patents by Inventor Milla Mikkola

Milla Mikkola has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Carbohydrate profile compositions from human cells and methods for analysis and modification thereof
    Patent number: 9410126
    Abstract: The invention describes methods for production of novel composition of glycans, glycomes, from human multipotent stem cells. The invention is further directed to methods for modifying the glycomes and analysis of the glycomes and the modified glycomes. Furthermore the invention is directed to stem cells carrying the modified glycomes on their surfaces.
    Type: Grant
    Filed: March 6, 2014
    Date of Patent: August 9, 2016
    Assignee: GLYKOS FINLAND OY
    Inventors: Tero Satomaa, Jari Natunen, Jarmo Laine, Annamari Heiskanen, Maria Blomqvist, Anne Olonen, Juhani Saarinen, Taina Jaatinen, Ulla Impola, Milla Mikkola, Heidi Anderson
  • A METHOD FOR GENERATING INDUCED PLURIPOTENT STEM CELLS
    Publication number: 20160068818
    Abstract: The invention relates to a method for generating induced pluripotent stem cells, wherein the method comprises: step a) of inducing non-pluripotent cells to produce a mixture comprising induced pluripotent stem cells and non-pluripotent cells; step b) of contacting the mixture comprising induced pluripotent stem cells and non-pluripotent cells obtainable from step a) with a binding agent, wherein the binding agent is capable of binding an epitope consisting of the non-reducing terminal saccharide structure according to formula (Fuc?1-2)aGal?1-3HexNAc?, wherein a=0 or 1 and Hex is either Glc or Gal; and step c) of selecting an induced pluripotent stem cell bound by the binding agent.
    Type: Application
    Filed: April 16, 2014
    Publication date: March 10, 2016
    Applicant: Glykos Finland Oy
    Inventors: Milla MIKKOLA, Timo OTONKOSKI, Heli Mononen, Tero SATOMAA, Juhani SAARINEN
  • NOVEL CARBOHYDRATE PROFILE COMPOSITIONS FROM HUMAN CELLS AND METHODS FOR ANALYSIS AND MODIFICATION THEREOF
    Publication number: 20150072419
    Abstract: The invention describes methods for production of novel composition of glycans, glycomes, from human multipotent stem cells. The invention is further directed to methods for modifying the glycomes and analysis of the glycomes and the modified glycomes. Furthermore the invention is directed to stem cells carrying the modified glycomes on their surfaces.
    Type: Application
    Filed: March 6, 2014
    Publication date: March 12, 2015
    Inventors: Tero SATOMAA, Jari NATUNEN, Jarmo LAINE, Annamari HEISKANEN, Maria BLOMQVIST, Anne OLONEN, Juhani SAARINEN, Taina JAATINEN, Ulla IMPOLA, Milla MIKKOLA, Heidi ANDERSON
  • Culture of cells
    Patent number: 8703488
    Abstract: The invention relates to a method for culturing human embryonic stem cells (hESCs) and/or induced pluripotent stem (iPS) cells on a lectin. The invention relates also to the use of a lectin in a method for culturing human embryonic stem cells (hESCs) and/or induced pluripotent stem (iPS) celts and a culture medium composition containing a lectin attached on the culturing plates.
    Type: Grant
    Filed: July 13, 2009
    Date of Patent: April 22, 2014
    Assignees: Suomen Punainen Risti Veripalvelu, Glykos Finland Oy
    Inventors: Ulla Impola, Minna Tiittanen, Milla Mikkola, Jukka Partanen, Jari Natunen, Tero Satomaa, Juhani Saarinen
  • Carbohydrate profile compositions from human cells and methods for analysis and modification thereof
    Patent number: 8691774
    Abstract: The invention describes methods for production of novel composition of glycans, glycomes, from human multipotent stem cells. The invention is further directed to methods for modifying the glycomes and analysis of the glycomes and the modified glycomes. Furthermore the invention is directed to stem cells carrying the modified glycomes on their surfaces.
    Type: Grant
    Filed: July 11, 2006
    Date of Patent: April 8, 2014
    Assignee: Glykos Finland Oy
    Inventors: Tero Satomaa, Jari Natunen, Jarmo Laine, Annamari Heiskanen, Maria Blomqvist, Anne Olonen, Juhani Saarinen, Taina Jaatinen, Ulla Impola, Milla Mikkola, Heidi Anderson
  • CULTURE OF CELLS
    Publication number: 20110306128
    Abstract: The invention relates to a method for culturing human embryonic stem cells (hESCs) and/or induced pluripotent stem (iPS) cells on a lectin. The invention relates also to the use of a lectin in a method for culturing human embryonic stem cells (hESCs) and/or induced pluripotent stem (iPS) celts and a culture medium composition containing a lectin attached on the culturing plates.
    Type: Application
    Filed: July 13, 2009
    Publication date: December 15, 2011
    Applicants: GLYKOS FINLAND OY, SUOMEN PUNAINEN RISTI VERIPALVELU
    Inventors: Ulla Impola, Minna Tiittanen, Milla Mikkola, Jukka Partanen, Jari Natunen, Tero Satomaa, Juhani Saarinen
  • NOVEL CARBOHYDRATE PROFILE COMPOSITIONS FROM HUMAN CELLS AND METHODS FOR ANALYSIS AND MODIFICATION THEREOF
    Publication number: 20100145032
    Abstract: The invention describes reagents and methods for specific binders to glycan structures of stem cells. Furthermore the invention is directed to screening of additional binding reagents against specific glycan epitopes on the surfaces of the stem cells. The preferred binders of the glycans structures includes proteins such as enzymes, lectins and antibodies.
    Type: Application
    Filed: January 18, 2008
    Publication date: June 10, 2010
    Applicants: Suomen Punainen Risti, Veripalelu, Glykos Finland Ltd.
    Inventors: Jarmo Laine, Tero Satomaa, Jari Natunen, Annamari Heiskanen, Maria Blomqvist, Anne Olonen, Juhani Saarinin, Sari Tiitinen, Ulla Impola, Milla Mikkola, Hanna Salo, Olli Aitio, Leena Valmu, Suvi Natunen, Heidi Anderson, Virve Pitkänen, Jukka Partanen, Taina Jaatinen, Minna Tiitanen, Tia Hirvonen
  • CULTURE OF HUMAN EMBRYONIC CELLS
    Publication number: 20100120142
    Abstract: The invention relates to a method for culturing human embryonic stem cells (hESCs) with a lectin. The invention relates also to the use of a lectin in a method for culturing human embryonic stem cells (hESCs) and a culture medium composition containing a lectin.
    Type: Application
    Filed: July 11, 2008
    Publication date: May 13, 2010
    Applicants: SUOMEN PUNAINEN RISTI VERIPALVELU, Glykos Finland Oy
    Inventors: Ulla Impola, Minna Tiittanen, Milla Mikkola, Jukka Partanen, Jari Natunen, Tero Satomaa, Juhani Saarinen
  • NOVEL METHODS AND REAGENTS DIRECTED TO PRODUCTION OF CELLS
    Publication number: 20100068806
    Abstract: The present invention provides methods and materials to modulate and grow stem cells by contacting stem cells with a binder recognizing terminal glycan structures of stem cells. The modulation can be morphological change, change in differentiation status, biological status or adherence. The materials provided in the present invention are also useful to screen such a binding agents and binders.
    Type: Application
    Filed: January 18, 2008
    Publication date: March 18, 2010
    Applicants: SUOMEN PUNAINEN RISTI, VERIPALVELU, Glykos Finland Ltd.
    Inventors: Jarmo Laine, Tero Satomaa, Jari Natunen, Annamari Heiskanen, Maria Blomqvist, Anne Olonen, Juhani Saarinen, Sari Tiitiene, Ulla Impola, Milla Mikkola, Leena Valmu, Minna Tiittanen
  • Novel Carbohydrate Profile Compositions From Human Cells and Methods for Analysis and Modification Thereof
    Publication number: 20100055710
    Abstract: The invention describes methods for production of novel composition of glycans, glycomes, from human multipotent stem cells. The invention is further directed to methods for modifying the glycomes and analysis of the glycomes and the modified glycomes. Furthermore the invention is directed to stem cells carrying the modified glycomes on their surfaces.
    Type: Application
    Filed: July 11, 2006
    Publication date: March 4, 2010
    Applicants: SUOMEN PUNAINEN RISTI, VERIPALVELU, GLYKOS FINLAND OY
    Inventors: Tero Satomaa, Jari Natunen, Jarmo Laine, Annamari Heiskanen, Maria Blomqvist, Anne Olonen, Juhani Saarinen, Taina Jaatinen, Ulla Impola, Milla Mikkola, Heidi Anderson
  • NOVEL CELLULAR GLYCAN COMPOSITIONS
    Publication number: 20090317834
    Abstract: The invention describes novel compositions of glycans, glycomes, from human embryonic stem cells, and especially novel subcompositions of the glycomes with specific monosaccharide compositions and glycan structures. The invention is further directed to methods for modifying the glycomes and analysis of the glycomes and the modified glycomes. Furthermore, the invention is directed to stem cells carrying the modified glycomes on their surfaces. The glycomes are preferably analysed by profiling methods able to detect reproducibly and quantitatively numerous individual glycan structures at the same time. The most preferred type of the profile is a mass spectrometric profile. The invention specifically revealed novel target structures and is especially directed to the development of reagents recognizing the structures.
    Type: Application
    Filed: June 29, 2007
    Publication date: December 24, 2009
    Inventors: Jarmo Laine, Tero Satomaa, Jari Natunen, Annamari Heiskanen, Juhani Saarinen, Taina Jaatinen, Milla Mikkola, Suvi Natunen
  • Novel Carbohydrate Profile Compositions From Human Cells and Methods for Analysis and Modification Thereof
    Publication number: 20090162938
    Abstract: The invention describes methods for production of novel composition of glycans, glycomes, from human multipotent stem cells. The invention is further directed to methods for modifying the glycomes and analysis of the glycomes and the modified glycomes. Furthermore the invention is directed to stem cells carrying the modified glycomes on their surfaces.
    Type: Application
    Filed: November 8, 2006
    Publication date: June 25, 2009
    Applicants: SUOMEN PUNAINEN RISTI,VERIPALVELU, GLYKOS FINLAND OY
    Inventors: Jarmo Laine, Tero Satomaa, Jari Natunen, Annamari Heiskanen, Maria Blomqvist, Anne Olonen, Juhani Saarinen, Taina Jaatinen, Ulla Impola, Milla Mikkola