Patents by Inventor Mills T. Kneller
Mills T. Kneller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8680334Abstract: A process for the preparation of iosimenol comprising reacting 5,5?-[(1,3-dioxo-1,3-propanediyl)diimino]bis[N-(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide] (C-VI) with a 3-halo-1,2-propanediol in an aqueous solvent. A process for the preparation of C-VI comprising reacting 3,3?-[(1,3-dioxo-1,3-propanediyl)diimino]bis[5-(aminocarbonyl)-2,4,6-triiodobenzoyl chloride] (C-V) with 3-amino-1,2-propanediol in the presence of an inorganic base and a suitable non-aqueous polar solvent. A process for the preparation of C-V comprising reacting 3-amino-5-(aminocarbonyl)-2,4,6-triiodobenzoyl chloride (C-IV) with malonyl dichloride in a solvent comprising a suitable ester solvent, a suitable nitrile solvent or mixtures thereof.Type: GrantFiled: February 21, 2013Date of Patent: March 25, 2014Assignee: Mallinckrodt LLCInventors: Allan R. Bailey, Michelle M. Jones, Mills T. Kneller, Alexander N. Petrov, David H. White, Oliver Egan, Fiona Rooney
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Publication number: 20130261338Abstract: A process for the preparation of iosimenol comprising reacting 5,5?-[(1,3-dioxo-1,3-propanediyl)diimino]bis[N-(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide] (C-VI) with a 3-halo-1,2-propanediol in an aqueous solvent. A process for the preparation of C-VI comprising reacting 3,3?4(1,3-dioxo-1,3-propanediyl)diimino]bis[5-(aminocarbonyl)-2,4,6-triiodobenzoyl chloride] (C-V) with 3-amino-1,2-propanediol in the presence of an inorganic base and a suitable non-aqueous polar solvent. A process for the preparation of C-V comprising reacting 3-amino-5-(aminocarbonyl)-2,4,6-triiodobenzoyl chloride (C-IV) with malonyl dichloride in a solvent comprising a suitable ester solvent, a suitable nitrile solvent or mixtures thereof.Type: ApplicationFiled: February 21, 2013Publication date: October 3, 2013Applicant: Mallinckrodt LLCInventors: Allan R. Bailey, Michelle M. Jones, Mills T. Kneller, Alexander N. Petrov, David H. White, Oliver Egan, Fiona Rooney
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Patent number: 8445725Abstract: A process for the preparation of iosimenol comprising reacting 5,5?-[(1,3-dioxo-1,3-propanediyl)diimino]bis[N-(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide] (C-VI) with a 3-halo-1,2-propanediol in an aqueous solvent. A process for the preparation of C-VI comprising reacting 3,3?-[(1,3-dioxo-1,3-propanediyl)diimino]bis[5-(aminocarbonyl)-2,4,6-triiodobenzoyl chloride] (C-V) with 3-amino-1,2-propanediol in the presence of an inorganic base and a suitable non-aqueous polar solvent. A process for the preparation of C-V comprising reacting 3-amino-5-(aminocarbonyl)-2,4,6-triiodobenzoyl chloride (C-IV) with malonyl dichloride in a solvent comprising a suitable ester solvent, a suitable nitrile solvent or mixtures thereof.Type: GrantFiled: January 14, 2009Date of Patent: May 21, 2013Assignee: Mallinckrodt LLCInventors: Allan R. Bailey, Michelle M. Jones, Mills T. Kneller, Alexander N. Petrov, David H. White, Oliver Egan, Fiona Rooney
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Publication number: 20120184772Abstract: The present disclosure is directed to a process for preparing an alkylated triiodo-substituted arylamide, such as iodixanol, the process comprising contacting a triiodo-substituted arylamide, such as 5-acetamido-N,N?-bis(2,3-dihydroxylpropyl)-2,4,6-triiodoisophthalamide, and an alkylating agent in the presence of a base and a mixed solvent system comprising a non-aqueous solvent and water, wherein the volume ratio of the non-aqueous solvent to water is greater than 1:1. The process advantageously enables the concentration of any impurities or undesirable byproduct from the reaction to be reduced, while increasing the yield of the desired reaction product.Type: ApplicationFiled: September 28, 2010Publication date: July 19, 2012Inventors: Allan R. Bailey, Michelle M. Jones, Tino J. Caviggiola, III, Mills T. Kneller, Alexander N. Petrov, Michael A. Brown, Benjamin J. Costello
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Publication number: 20100280270Abstract: A process for the preparation of iosimenol comprising reacting 5,5?-[(1,3-dioxo-1,3-propanediyl)diimino]bis[N-(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide] (C-VI) with a 3-halo-1,2-propanediol in an aqueous solvent. A process for the preparation of C-VI comprising reacting 3,3?-[(1,3-dioxo-1,3-propanediyl)diimino]bis[5-(aminocarbonyl)-2,4,6-triiodobenzoyl chloride] (C-V) with 3-amino-1,2-propanediol in the presence of an inorganic base and a suitable non-aqueous polar solvent. A process for the preparation of C-V comprising reacting 3-amino-5-(aminocarbonyl)-2,4,6-triiodobenzoyl chloride (C-IV) with malonyl dichloride in a solvent comprising a suitable ester solvent, a suitable nitrile solvent or mixtures thereof.Type: ApplicationFiled: January 14, 2009Publication date: November 4, 2010Inventors: Allan R. Bailey, Michelle M. Jones, Mills T. Kneller, Alexander N. Petrov, David H. White, Oliver Egan, Fiona Rooney
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Patent number: 5489708Abstract: The reduction of the O-alkyl isomer content of 5-[N-(2-acetoxyethyl)acetoxyacetamido]-N,N'-bis(2,3-diacetoxypropyl)-2,4,6 -triiodoisophthalamide to thereby reduce and/or eliminate the production of impurities comparatively more difficult to remove during the purification of crude ioversol.Type: GrantFiled: December 1, 1993Date of Patent: February 6, 1996Assignee: Mallinckrodt Medical, Inc.Inventors: Allan R. Bailey, Sharad S. Sathe, Andre T. Spears, Richard C. Wisneski, Mills T. Kneller
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Patent number: 5385724Abstract: Methods and compositions are disclosed for enhancing .sup.19 F magnetic resonance imaging which utilize trifluoromethyl derivatives of iodinated X-ray contrast media. Typical magnetic resonance contrast media within the scope of the present invention include bis(trifluoromethyl)benzene derivatives, tris(trifluoromethyl)benzene derivatives, tetrakis(trifluoromethyl)benzene derivatives, and other related trifluoromethylated benzene derivatives.Type: GrantFiled: March 4, 1994Date of Patent: January 31, 1995Assignee: Mallinckrodt Medical, Inc.Inventors: David H. White, Steven R. Woulfe, Youlin Lin, Mills T. Kneller
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Patent number: 5371278Abstract: The use of a minimal excess of acetoxyacetylchloride as a reagent in the synthesis of N,N'-bis(2,3-dihydroxypropyl)-5-N-(2-hydroxy-ethyl)glycolamido-2,4,6-triio doisophthalamide.Type: GrantFiled: March 25, 1994Date of Patent: December 6, 1994Assignee: Mallinckrodt Medical PMCInventors: William Z. McCarthy, Mills T. Kneller, Youlin Lin, Rebecca A. Wallace, David H. White
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Patent number: 5322934Abstract: The use of continuous deionization as an alternative or substitute method for the purification of a crude magnetic resonate.Type: GrantFiled: September 2, 1992Date of Patent: June 21, 1994Assignee: Mallinckrodt Medical, Inc.Inventor: Mills T. Kneller
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Patent number: 5318770Abstract: Methods and compositions are disclosed for enhancing .sup.19 F magnetic resonance imaging which utilize trifluorometyl derivatives of iodinated X-ray contrast media. Typical magnetic resonance contrast media within the scope of the present invention include bis(trifluoromethyl)benzene derivatives, tris(trifluoromethyl)benzene derivatives, tetrakis(trifluoromethyl)benzene derivatives, and other related trifluoromethylated benzene derivatives.Type: GrantFiled: October 25, 1991Date of Patent: June 7, 1994Assignee: Mallinckrodt Medical, Inc.Inventors: David H. White, Steven R. Woulfe, Youlin Lin, Mills T. Kneller
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Patent number: 5256393Abstract: The use of azeotropic distillation to dry 5-amino-N,N'bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide, an intermediate in the production of N,N'-bis(2,3-dihydroxypropyl)-5-N-(2-hydroxyethyl)glycolamido-2,4,6-triiod oisophthalamide.Type: GrantFiled: April 16, 1991Date of Patent: October 26, 1993Assignee: Mallinckrodt Medical, Inc.Inventors: William Z. McCarthy, Mills T. Kneller, Youlin Lin, David H. White
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Patent number: 5221485Abstract: The use of reverse osmosis as an alternative or substitute method for the purification of a crude diagnostic agent. X-ray contrast agent, magnetic resonance imaging agent, or radiopharmaceuticals are purified by passing through a cross-linked reverse osmosis membrane.Type: GrantFiled: October 2, 1992Date of Patent: June 22, 1993Assignee: Mallinckrodt Medical, Inc.Inventors: Mark E. Bosworth, Thomas J. Dunn, Warren E. Hall, Richard G. Johnson, Mills T. Kneller, Youlin Lin, Rebecca A. Wallace, David H. White, David M. Wong
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Patent number: 5210300Abstract: The use of continuous deionization as an alternative or substitute method for the purification of a crude contrast agent.Type: GrantFiled: September 25, 1991Date of Patent: May 11, 1993Assignee: Malinckrodt Medical, Inc.Inventor: Mills T. Kneller
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Patent number: 5204005Abstract: An improved process for the reversed phase chromatographic decolorization, separation, and purification of water-soluble, nonionic contrast media compounds from solutions containing nonionic compound impurities involves the steps of (a) packing a chromatographic column with a chromatographic packing material; (b) passing through the column a solution containing a water-soluble, nonionic contrast media compound and nonionic compounds as impurities at a loading ratio between approximately 10 to 1 and 1.5 to 1 wt. packing material/total wt. nonionic compounds; and (c) eluting the column to produce an eluate containing substantially pure, water-soluble, nonionic contrast media compound or MRI agent. The process can be economically practiced on a factory scale and efficiently removes non-polar impurities difficult to remove by conventional methods.Type: GrantFiled: January 28, 1991Date of Patent: April 20, 1993Assignee: Mallinckrodt, Inc.Inventors: Narciso O. Doran, III, Thomas J. Dunn, Mills T. Kneller, Youlin Lin, David H. White, David Ming-Lee Wong
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Patent number: 5191120Abstract: Triiodinated isophthalamide derivatives, useful as X-ray contrast agents, having at least one amide group derived from the amino-alcohol, 3-(N-2-hydroxyethyl)amino-1,2-propanediol, which provides high water solubility and low mammalian toxicity, and methods of preparing them. Methods of preparing 3-(N-2-hydroxyethyl)amino-1,2-propanediol are provided.Type: GrantFiled: September 24, 1991Date of Patent: March 2, 1993Assignee: Mallinckrodt Medical, Inc.Inventors: Mills T. Kneller, Youlin Lin, James R. Wheatley
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Patent number: 5177261Abstract: The use of chloroacetylchloride as an alternative or substitute reagent for acetoxychloride in the synthesis of N,N'- bis (2,3-dihydroxypropyl)-5-N-(2-hydroxyethyl)glycolamido-2,4,6-triiodoisophth alamide.Type: GrantFiled: July 22, 1991Date of Patent: January 5, 1993Assignee: Mallinckrodt Medical, Inc.Inventors: William Z. McCarthy, Mills T. Kneller, Youlin Lin, David H. White
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Patent number: 5160437Abstract: The use of reverse osmosis as an alternative or substitute method for the purification of a crude diagnostic agent. In the purification process a crude Ioversol solution is contacted with a cross-linked membrane under pressure, forcing the low molecular weight impurities within the crude Ioversol solution through the membrane pores and retaining Ioversol molecules.Type: GrantFiled: December 3, 1991Date of Patent: November 3, 1992Assignee: Mallinckrodt Medical, Inc.Inventors: Mark E. Bosworth, Thomas J. Dunn, Warren E. Hall, Richard G. Johnson, Mills T. Kneller, Youlin Lin, Rebecca A. Wallace, David H. White, David M. Wong
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Patent number: 5075502Abstract: Triiodinated isophthalamide derivatives, useful as X-ray contrast agents, having at least one amide group derived from the amino-alcohol, 3-(N-2-hydroxyethyl)amino-1,2-propanediol, which provides high water solubility and low mammalian toxicity, and methods of preparing them. Methods of preparing 3-(N-2-hydroxyethyl)amino-1,2-propanediol are provided.Type: GrantFiled: December 13, 1989Date of Patent: December 24, 1991Assignee: Mallinckrodt, Inc.Inventors: Mills T. Kneller, Youlin Lin, James R. Wheatley
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Patent number: 4066743Abstract: 3-Acetamido-5-(4,4-bishydroxymethyl-2-oxazolinyl)-2,4,6-triiodobenzoic acid, 3-acetamido-5-(4-methyl-4-hydroxymethyl-2-oxazolinyl)-2,4,6-triiodob enzoic acid, analogous compounds and salts and esters thereof are useful as X-ray contrast agents. The corresponding acyl halides are useful as intermediates.Type: GrantFiled: June 21, 1976Date of Patent: January 3, 1978Assignee: Mallinckrodt, Inc.Inventor: Mills T. Kneller