Abstract: A valve has a flexible sheet member which moves toward and away from a flat, non-flexing sheet member to cover and open two holes in the nonflexing sheet member to block or permit fluid flow between passageways in a second valve body portion member. The flexible sheet member is extendible into a recess formed in a first valve body portion member above the two holes so that fluid flows from one passageway through a chamber formed between the non-flexing sheet member surface and the faring surface of the flexible sheet member. The plunger head of a solenoid forces the flexible sheet member into contact with the non-flexing sheet member and when excited causes the plunger head to be moved out of contact with the flexible sheet member allowing the flexible sheet member to uncover the holes in the nonflexing sheet member.

Abstract: A method of producing a fluidic module from two or more pieces (B.sub.1 B.sub.2) of plastic material having an intermolecular bonded interface, comprises forming an interface surface (2) on each piece, forming at least one fluidic passageway (4) in at least one of the interface surfaces, assembling the pieces with the interface surfaces in contact with each other and confining them against expansion. Heat is applied to the assembled pieces to induce their expansion against total or limited confinement to cause transmigration of molecules from one interface surface to the other to bond the pieces together.

Abstract: A method of producing a fluidic module from two or more pieces (B.sub.1 B.sub.2) of plastic material having an intermolecular bonded interface, comprises forming an interface surface (2) on each piece, forming at least one fluidic passageway (4) in at least one of the interface surfaces, assembling the pieces with the interface surfaces in contact with each other and confining them against expansion. Heat is applied to the assembled pieces to induce their expansion against total or limited confinement to cause transmigration of molecules from one interface surface to the other to bond the pieces together.

Abstract: A valve is disclosed comprising a first body portion (2) having a first surface (16), a second body portion (4) having a second surface (51) facing the first surface, a flexible sheet (8) positioned between the first and second surfaces, a void (4) in the first body portion created and defined by a concave surface (46) formed in the first surface and one side (18) of the flexible sheet. There are at least two fluid passageways (20) (22) in the first body portion communicating with the void at spaced locations, at least one of the fluid passageways being a channel formed in the first surface and terminating at the void.

Abstract: An analysis system includes sample insertion module structure with structure defining a reduced pressure reservoir, structure defining a sample region, and structure defining a reagent circuit that includes metering chamber structure in series with the reagent circuit. First transfer valve structure is arranged to couple the sample region to the reagent circuit on one side of the metering chamber structure, and second transfer valve structure is arranged to couple the reagent circuit to the reduced pressure reservoir structure on the side of the metering chamber structure remote from the first transfer valve structure for inserting an intact metered quantity of sample liquid into a reagent stream.

Abstract: A valve is disclosed comprising a first body portion (2) having a first surface (16), a second body portion (4) having a second surface (51) facing the first surface, a flexible sheet (8) positioned between the first and second surfaces, a void (4) in the first body portion created and defined by a concave surface (46) formed in the first surface and one side (18) of the flexible sheet. There are at least two fluid passageways (20) (22) in the first body portion communicating with the void at spaced locations, at least one of the fluid passageways being a channel formed in the first surface and terminating at the void.

Abstract: A valve is disclosed comprising a first body portion (2) having a first surface (16), a second body portion (4) having a second surface (51) facing the first surface, a flexible sheet (8) positioned between the first and second surfaces, a void (4) in the first body portion created and defined by a concave surface (46) formed in the first surface and one side (18) of the flexible sheet.There are at least two fluid passageways (20) (22) in the first body portion communicating with the void at spaced locations, at least one of the fluid passageways being a channel formed in the first surface and terminating at the void.

Abstract: A liquid handling system useful in apparatus for analyzing biological liquid specimens or the like includes a plurality of sample metering chambers, a distribution manifold connected between a sample inlet port and the sample metering chambers, and a corresponding plurality of auxiliary liquid metering chambers connected to corresponding auxiliary liquid reservoirs. Liquids are flowed from the sample inlet port through the distribution manifold to the sample metering chambers and from auxiliary liquid reservoirs to the auxiliary liquid metering chambers under the influence of reduced pressures which are selectively connected to the flow network through an integrated valve array and reduced pressure manifolds.

Abstract: A valve that is particularly useful in biological fluid handling systems includes a body member that has a firm and stable support surface and a flexible sheet member that has a surface for conforming and mating engagement with the surface of the valve body member. A land portion in the surface of one of the valve members separates two fluid flow channels in that member. An actuator is arranged to flex the sheet member between a first position in which the surface of the sheet member is in mating and sealing engagement with the surface of the body member to sealing block flow between the two channels, and a second position in which the sheet surface is spaced from the first position to allow fluid flow across the land surface between the two flow channels.

Abstract: A system for analyzing a biological fluid specimen or the like includes an analysis chamber and an electrochemical electrode measuring system connected in sensing relation to the analysis chamber. A flow network connects a sample inlet port and an auxiliary fluid reservoir to the analysis chamber. The flow network includes a sample line connected between the sample inlet port and the analysis chamber and an auxiliary manifold connected to the auxiliary fluid reservoir. A positive displacement pump is connected in the sample line between the analysis chamber and a waste outlet port.

Abstract: Apparatus for analyzing the contents of a sealed package includes a package alignment assembly, and a probe assembly that has a puncturing tip. The package alignment assembly includes a positioning support surface in alignment with the puncturing tip and supplemental resiliently supported structure spaced from the support surface for aligning the package to be analyzed with the probe assembly. A flow path extends from the puncturing tip to an analysis unit for withdrawing and analyzing a sample of the contents of the package.

Abstract: A portable fluid analyzer has a sampling section with flow passage structure for sealing engagement with a discharge port of a zwickel fitting or the like and retainer structure for engagement with the fitting. The retainer structure is urged by a spring towards a retaining position and is movable, by a manual operator towards a released position. When the retainer structure is engaged with the fitting and the manual operator is released, the sealing member is urged by the spring into engagement with the fitting's discharge port. The analyzer also includes an analysis chamber connected to the discharge end of the flow passage structure and monitoring means for providing an output as a function of a constituent of the fluid in the analysis chamber.