Abstract: Systems, devices, and methods for segmentation of patient anatomy are described herein. A method can include receiving a three-dimensional (3D) scan volume including a set of images of a 3D region of patient anatomy. The 3D region of patient anatomy can include a set of anatomical structures. The method can also include generating a set of two-dimensional (2D) radiographs using the 3D scan volume. Each 2D radiograph from the set of 2D radiographs can include 3D image data extracted from the 3D scan volume. The method can also include training a segmentation model to segment 2D radiographs using the set of 2D radiographs to identify one or more anatomical parts of interest.