Patents by Inventor Milos Barut

Milos Barut has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chromatographic device
    Patent number: 6736973
    Abstract: A porous self-supporting structure comprising at least two porous components A and B and the porous component B embraces the porous component A, wherein (i) surfaces of pores of the at least two porous components A and B are provided with chemical moieties for interaction with substances passing the pores and (ii) the pores of the porous components comprise a uniform multimodal pore size distribution through the entire polymeric structure.
    Type: Grant
    Filed: July 26, 2000
    Date of Patent: May 18, 2004
    Assignee: BIA Separations d.o.o.
    Inventors: Ales Podgornik, Milos Barut, Ales Strancar, Djuro Josic
  • Method and device for isolating and purifying a polynucleotide of interest on a manufacturing scale
    Publication number: 20040002081
    Abstract: The invention relates to a process for isolating and purifying a polynucleotide on a manufacturing scale which uses a chromatographic separation process comprising a combination of two different chromatographic steps selected from hydrophobic interaction chromatography, polar interaction chromatography and anion exchange chromatography. In at least one of the two steps the chromatographic support is a porous monolithic bed. The invention also relates to a chromatographic device and its use for isolating and purifying a polynucleotide of interest, in particular plasmid DNA, on manufacturing scale.
    Type: Application
    Filed: December 18, 2002
    Publication date: January 1, 2004
    Applicant: Boehringer Ingelheim International GmbH and BIA Separations d.o.o.
    Inventors: Jochen Urthaler, Roman Necina, Janez Jancar, Ales Podgornik, Milos Barut, Ales Strancar, Mojca Merhar
  • Chromatography material and a process of manufacturing that material
    Patent number: 6664305
    Abstract: A process of manufacturing of a chromatography material comprising the steps of (i) reacting a polymerizable at least bifunctional monomer A with a ligand also having a functional group which binds covalently with one of the functional groups of said polymerizable bifunctional monomer A, (ii) to form a compound B comprising at least one polymerizable functional moiety (iii) polymerizing the compound B essentially alone or with the polymerizable monomers in presence of porogenes to obtain a block of porous polymerizate which is self-supporting or (iv) reacting the ligand and a spacer via a covalent bond which is cleavable to form a ligand-spacer conjugate and binding the ligand-spacer conjugate to the surface of a chromatographic support or reacting the ligand-spacer conjugate via a covalent bond to the at least bi-functional monomer A and polymerizing it essentially alone or with the polymerizable monomers in presence of porogenes to obtain a block of porous polymerizate which is self-supporting.
    Type: Grant
    Filed: October 28, 2002
    Date of Patent: December 16, 2003
    Assignee: BIA Separations d.o.o.
    Inventors: Alois Jungbauer, Rainer Hahn, Ales Podgornik, Milos Barut, Ales Strancar
  • Chromatography material and a process of manufacturing that material
    Publication number: 20030125204
    Abstract: A process of manufacturing of a chromatography material comprising the steps of
    Type: Application
    Filed: October 28, 2002
    Publication date: July 3, 2003
    Inventors: Alois Jungbauer, Rainer Hahn, Ales Podgornik, Milos Barut, Ales Strancar