Abstract: A device for producing nanofibers or microfibers from solutions, emulsions, liquid suspensions or melts containing a spun substance, comprises a chamber in which a hollow shaft is assembled, on which at least one rotating disc with an output gap is mounted, The chamber is generally provided with a source of the flowing gas and a collection area. In an alternative embodiment, the chamber is provided with a number of side by side arranged hollow shafts. It is preferred that at least one hollow shaft is provided with two superposed rotating discs. At least one rotating disc is composed of two successive parts, wherein between the upper part and the lower part an outlet gap is formed around the circumference thereof. The size of the outlet gap between the upper part and the lower part of rotating disc may be formed by a spacer element, in particular a spacer ring.

Abstract: A device for producing nanostructured or microstructured with materials comprises a chamber in which a hollow shaft is assembled, at least one disc provided with an expansion gap. The hollow shaft has openings which connect the inner space of the hollow shaft with the expansion gap. A solution, emulsion or liquid suspension of substances or microorganisms optionally saturated with a gas, liquefied gas or supercritical liquid, is fed into an inner space of a disc through a hollow shaft. By means of the combination of a centrifugal force and fluid pressure occurs the outlet of the liquid through an expansion gap, to form microscopic droplets. The microscopic droplets are subsequently disintegrated by expansion of the gas to form an aerosol. The aerosol is subsequently dried by a drying gas stream to form solids.

Abstract: A process is described for the preparation of novel 6 substituted derivatives of D-8-ergolin-I-ylacetamide and the pharmaceutically acceptable addition salts thereof. The described composition evidences superior antilactation and antinidation characteristics as compared with prior art compounds.