Abstract: A continuous flow system for passing fluid over a biofilm to simulate an oral environment is described. In one embodiment, the continuous flow system includes a plurality of channels fluidly connected by one or more channel connectors, an inflow conduit defining an inflow channel and an outflow conduit defining an outflow channel. The plurality of channels can receive the fluid via the inflow conduit from a reservoir positioned upstream of the flow cell housing and the outflow channel can receive the fluid from the plurality of channels.