Patents by Inventor Milos Sovak

Milos Sovak has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7763288
    Abstract: Skin care compositions and methods are provided comprising a highly hydrophobic substance, an alkaryl polyfluorocarbon, particularly a substituted phenyl-polyfluoroacylamino propanamide, an alkanol and refined oils and the oil triglyceride fractions in sufficient amount to provide substantial homogeneity. When employed for hirsutism, optionally antioxidants and moisturizer are added. For use against wrinkles, additionally vitamins, antioxidants and a mixture of extracts of naturally occurring substances are present.
    Type: Grant
    Filed: June 6, 2008
    Date of Patent: July 27, 2010
    Assignee: Biophysica, Inc.
    Inventors: Milos Sovak, Allen L. Seligson, Jiri Prokop
  • Publication number: 20080260875
    Abstract: Skin care compositions and methods are provided comprising a highly hydrophobic substance, an alkaryl polyfluorocarbon, particularly a substituted phenyl-polyfluoroacylamino propanamide, an alkanol and refined oils and the oil triglyceride fractions in sufficient amount to provide substantial homogeneity. When employed for hirsutism, optionally antioxidants and moisturizer are added. For use against wrinkles, additionally vitamins, antioxidants and a mixture of extracts of naturally occurring substances are present.
    Type: Application
    Filed: June 6, 2008
    Publication date: October 23, 2008
    Applicant: BIOPHYSICA, INC.
    Inventors: Milos Sovak, Allen L. Seligson, Jiri Prokop
  • Patent number: 7250153
    Abstract: This invention comprises new formulations of radiographic contrast media including dimeric non-ionic media, with an organic amine and a carboxylic acid. Formulations of this invention increase the biological tolerance of such media, thereby increasing their safety.
    Type: Grant
    Filed: November 5, 2003
    Date of Patent: July 31, 2007
    Assignee: Biophysica Research, Inc.
    Inventors: Milos Sovak, Allen L. Seligson, Ronald C. Terry
  • Publication number: 20070048246
    Abstract: Skin care compositions are provided comprising a highly hydrophobic substance, an alkaryl polyfluorocarbon, particularly a substituted phenyl-polyfluoroacylamino propanamide, an alkanol and refined oils and the oil triglyceride fractions in sufficient amount to provide substantial homogeneity. When employed for hirsutism, optionally antioxidants and moisturizer are added. For use against wrinkles, additionally vitamins, antioxidants and a mixture of extracts of naturally occurring substances are present.
    Type: Application
    Filed: August 24, 2006
    Publication date: March 1, 2007
    Applicant: Biophysica Research, Inc.
    Inventors: Milos Sovak, Allen Seligson, Jiri Prokop
  • Publication number: 20050025711
    Abstract: This invention comprises new formulations of radiographic contrast media including dimeric non-ionic media, with an organic amine and a carboxylic acid. Formulations of this invention increase the biological tolerance of such media, thereby increasing their safety.
    Type: Application
    Filed: November 5, 2003
    Publication date: February 3, 2005
    Inventors: Milos Sovak, Allen Seligson, Ronald Terry
  • Patent number: 6828458
    Abstract: Compound (2-hydroxy-2-methyl-N-(4-X-3-(trifluoromethyl)phenyl)-3-(2,2,2-perfluoroacylamino)propionamide) applied topically, specifically inhibits and/or eliminates cutaneous androgen receptors and thus finds cosmetic use in skin afflictions associated with excess androgens such as hair effluvium, hirsutism, acne and androgenic alopecia.
    Type: Grant
    Filed: May 25, 2000
    Date of Patent: December 7, 2004
    Assignee: Biophysica, Inc.
    Inventors: Milos Sovak, Allen L. Seligson, Brian Campion, Jason W. Brown
  • Publication number: 20040014732
    Abstract: Compound (2-hydroxy-2-methyl-N-(4-X-3-(trifluoromethyl)phenyl)-3-(2,2,2-perfluoroacylamino)propionamide) applied topically, specifically inhibits and/or eliminates cutaneous androgen receptors and thus finds cosmetic use in skin afflictions associated with excess androgens such as hair effluvium, hirsutism, acne and androgenic alopecia.
    Type: Application
    Filed: May 25, 2000
    Publication date: January 22, 2004
    Applicant: Biophysica, Inc.
    Inventors: Milos Sovak, Allen L Seligson, Brian Campion, Jason W Brown
  • Publication number: 20030199581
    Abstract: The biological activity of naturally occurring boswellic acids in specific plant extracts is enhanced by their peracetylation, preferably followed by silica gel treatment, or by peracetylation and mild oxidation to increase the ratio of 3-&bgr;-acetyl-11-keto-&bgr;-boswellic acid to &bgr;-boswellic acid, 3-&bgr;-acetyl-&bgr;-boswellic acid and 11-keto-&bgr;-boswellic acid. The enriched compositions compared to the commercial extracts have enhanced biological activity toward a variety of proliferative and/or inflammatory afflictions in mammalian hosts and demonstrate synergism with other phytochemicals.
    Type: Application
    Filed: March 12, 2003
    Publication date: October 23, 2003
    Inventors: Allen L. Seligson, Ronald C. Terry, Milos Sovak, Daniel Alexander
  • Patent number: 6472415
    Abstract: Substituted phenylalanines are provided comprising an hydantoin, urea or 2-hydroxyl, 2-methylpropionyl group, dimers thereof and alkyl, polyfluoroamido and haloarylamino derivatives thereof, as well as radiolabeled derivatives thereof. The compounds bind specifically to the androgen receptor and find use in indications associated with the androgen receptor, such as cell hyperplasia dependent on androgens, hirsutism, acne and androgenetic alopecia.
    Type: Grant
    Filed: February 11, 2000
    Date of Patent: October 29, 2002
    Assignee: Biophysica, Inc.
    Inventors: Milos Sovak, Allen L. Seligson, James Gordon Douglas, III, Brian Campion, Jason W. Brown
  • Patent number: 6184249
    Abstract: Substituted phenylalanines are provided comprising an hydantoin, urea or 2-hydroxyl, 2-methylpropionyl group, dimers thereof and alkyl, polyfluoroamido and haloarylamino derivatives thereof, as well as radiolabeled derivatives thereof. The compounds bind specifically to the androgen receptor and find use in the therapy of indications associated with the androgen receptor, such as, hirsutism, acne and androgenetic alopecia, and in the therapy and diagnosis of cell hyperplasia dependent on androgens.
    Type: Grant
    Filed: December 18, 1998
    Date of Patent: February 6, 2001
    Assignee: Biophysica, Inc.
    Inventors: Milos Sovak, Allen L. Seligson, James Gordon Douglass, III, Brian Campion, Jason W. Brown
  • Patent number: 6123928
    Abstract: Novel polymeric biologically inert compositions and their intermediates, as well as sunscreen formulations comprising them and making them invisible, are provided for broad range protection from ultraviolet radiation. Acryl polymers comprising at least two different ultraviolet absorbing moieties having different light absorbing ranges are employed in conjunction with other monomers to provide sunscreen polymers as microparticles. The polymer microparticles, once imbibed with carrier compounds, change the refractive index, thus providing invisible sunscreen formulations which offer enhanced protection without adverse physiological effects.
    Type: Grant
    Filed: July 21, 1998
    Date of Patent: September 26, 2000
    Assignee: Biophysica, Inc.
    Inventors: Milos Sovak, Ronald C. Terry, James G. Douglass, III, Farid Bakir, Jason Brown, Peter Cugley
  • Patent number: 6072069
    Abstract: Novel non-ionic contrast media are provided, which fulfill the requirements for x-ray visualization media, while being biodegradable. The compounds are characterized by being triiodo-3,5-diaminobenzoic acid derivatives, where the functional groups are derivatized with hydroxyalkyl groups and the amino functionalities are further derivatized with acyl substituents of one carbon acids. Also, triiodophloroglucinol oxyalkyl substituted derivatives are provided.
    Type: Grant
    Filed: November 4, 1998
    Date of Patent: June 6, 2000
    Assignee: Biophysica, Inc.
    Inventors: Milos Sovak, Allen L. Seligson, James Gordon Douglass, III
  • Patent number: 5801191
    Abstract: Novel taxoids are provided having enhanced water solubility and/or improved pharmacological properties as compared to paclitaxel. The subject taxoids comprise a functional group attached to a paclitaxel at the C-2' and/or C-7 position by a linking group. Functional groups present in the subject taxoids may be hydrophilic chains, groups capable of in vivo conversion to hydrophilic chains, targeting moieties capable of specifically binding with cellular receptors and water soluble polymers of at least 5 kD. The subject taxoids find use in the treatment of hosts suffering from a cellular proliferative disease.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: September 1, 1998
    Assignee: Biophysica Foundation
    Inventors: Jerome C. Bressi, James G. Douglass, III, Allen Seligson, Milos Sovak
  • Patent number: 5741924
    Abstract: Novel polymeric compositions and their intermediates are provided, providing for broad range protection from ultraviolet radiation. Acryl polymers comprising at least two different ultraviolet absorbing moieties having different light absorbing ranges are employed in conjunction with another hydrophilic monomer to provide sunscreen formulations for invisibility, and enhanced protection, without deleterious effects in the dermis.
    Type: Grant
    Filed: June 14, 1995
    Date of Patent: April 21, 1998
    Assignee: Biophysica Inc.
    Inventors: Milos Sovak, Ronald Calvin Terry, James Gordon Douglass, III, Farid Bakir
  • Patent number: 5698739
    Abstract: Novel triiodo 5-aminoisophthaldiamides are provided, where the amino and one of the amide nitrogens are substituted. The compounds have at least two hydroxyl groups and are found to provide low viscosity and osmolality. Procedures for preparing the compounds are provided.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: December 16, 1997
    Assignee: Schering Aktiengesellschaft
    Inventor: Milos Sovak
  • Patent number: 5656651
    Abstract: Substituted phenylthiohydantoins are provided for use in detecting the presence of tumor cells having androgenic receptors and providing for cytostatic and cytotoxic activity toward such cells. The subject compounds provide for vehicles for specific targeting to the androgenic receptor containing cells of cytostatic and/or cytotoxic agents, heavy or light radioactive or radioopaque atoms, and the like for detection and treatment of cancer cells involving androgenic receptors or blocking androgenic receptors.
    Type: Grant
    Filed: June 16, 1995
    Date of Patent: August 12, 1997
    Assignee: Biophysica Inc.
    Inventors: Milos Sovak, Jerome C. Bressi, James Gordon Douglass, III, Brian Campion, Wolfgang Wrasidlo
  • Patent number: 5487885
    Abstract: Novel polymeric compositions and their intermediates are provided, providing for broad range protection from ultraviolet radiation. Acryl polymers comprising at least two different ultraviolet absorbing moieties having different light absorbing ranges are employed in conjunction with another hydrophilic monomer to provide sunscreen formulations for invisibility, and enhanced protection, without deleterious effects in the dermis.
    Type: Grant
    Filed: December 9, 1993
    Date of Patent: January 30, 1996
    Assignee: Biophysica, Inc.
    Inventors: Milos Sovak, Ronald C. Terry, James G. Douglass, III, Farid Bakir
  • Patent number: 5191119
    Abstract: Methods are provided for substituting aromatic carboxylic acids and derivatives thereof and amino substituted aromatic carboxylic acids and derivatives thereof, by forming imides and imide-amides, respectively, by acylation with aliphatic carboxylic acids, substituting at least one nitrogen atom under mild basic conditions with an aliphatic compound having as alkylating agent a displaceable functionality and removing undesired acyl groups, as appropriate.
    Type: Grant
    Filed: July 5, 1990
    Date of Patent: March 2, 1993
    Assignee: Cook Imaging Corp.
    Inventors: Milos Sovak, Ramachandran Ranganathan
  • Patent number: 5056395
    Abstract: A cutter link for a chain saw chain containing a conical raker spaced forward of a round cutter face. The raker protects most of the cutter face from sudden impact and, together with the cutting and rake angles of the cutter face, provides for a filing rather than a chiseling action by the cutter link. Saw chains incorporating the novel cutter link are impact and wear resistant.
    Type: Grant
    Filed: January 24, 1990
    Date of Patent: October 15, 1991
    Assignee: Sovac Corporation
    Inventors: Milos Sovak, Robert A. Rauch
  • Patent number: 5035877
    Abstract: Novel non-ionic contrast media are efficiently prepared from generally available ionic contrast media. Particularly, polyhydroxyhalohydrocarbons are employed with a triiodo-substituted acylamido benzoic acids in aqueous weakly basic media to selectively substitute the amido nitrogen, followed by activation of the carboxyl group for amide formation.
    Type: Grant
    Filed: September 14, 1990
    Date of Patent: July 30, 1991
    Assignee: Cook Imaging Corporation
    Inventors: Milos Sovak, Ramachandran Ranganathan