Patents by Inventor Milton J. Zmijewski

Milton J. Zmijewski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis of (S)-.alpha.-methyl-1,3-benzodioxole-5-ethanol and derivatives
    Patent number: 6160133
    Abstract: A process for stereoselectively forming N-substituted dihydro-2,3 benzodiazepines which are useful as AMPA receptor antagonists. The process includes an opening reduction step which sets the stereochemistry of the intermediates and the final compounds to the desired enantiomer. The reduction step may be carried out by an enzymatic reduction.
    Type: Grant
    Filed: July 2, 1999
    Date of Patent: December 12, 2000
    Assignee: Eli Lilly and Company
    Inventors: David L. Varie, Jeffrey T. Vicenzi, Milton J. Zmijewski
  • Stereoselective process for producing dihydro-2,3-benzodiazepine derivatives
    Patent number: 5919954
    Abstract: A process for stereoselectively forming N-substituted dihydro-2,3 benzodiazepines which are useful as AMPA receptor antagonists. The process includes an opening reduction step which sets the stereochemistry of the intermediates and the final compounds to the desired enantiomer. The reduction step may be carried out by an enzymatic reduction.
    Type: Grant
    Filed: April 14, 1997
    Date of Patent: July 6, 1999
    Assignee: Eli Lilly and Company
    Inventors: Benjamin A. Anderson, Marvin M. Hansen, David L. Varie, Jeffrey T. Vicenzi, Milton J. Zmijewski
  • Stereoselective process for producing dihydro-2,3-benzodiazepine derivatives
    Patent number: 5665878
    Abstract: A process for stereoselectively forming N-substituted dihydro-2,3 benzodiazepines which are useful as AMPA receptor antagonists. The process includes an opening reduction step which sets the stereochemistry of the intermediates and the final compounds to the desired enantiomer. The reduction step may be carried out by an enzymatic reduction.
    Type: Grant
    Filed: March 28, 1995
    Date of Patent: September 9, 1997
    Assignee: Eli Lilly and Company
    Inventors: Benjamin A. Anderson, Marvin M. Hansen, David L. Varie, Jeffrey T. Vicenzi, Milton J. Zmijewski
  • Enzyme from microbial source: phthalyl amidase
    Patent number: 5607850
    Abstract: Phthalyl amidase is an enzyme previously unknown in the art that catalyzes removal of the phthalyl moiety from phthalyl-containing amides. The current invention provides said phthalyl amidase, means for producing it by culturing the natural organism from which the activity was identified, and methods for using said phthalyl amidase to remove the phthalyl moiety from phthalyl-containing amides.
    Type: Grant
    Filed: May 22, 1995
    Date of Patent: March 4, 1997
    Assignee: Eli Lilly and Company
    Inventors: Barbara S. Briggs, Milton J. Zmijewski, Jr.
  • Process for preparation of benzo[B]thiophene glucuronides
    Patent number: 5563054
    Abstract: The present invention provides a biotransformation process for preparing a compound of the formula ##STR1## wherein R.sub.1 and R.sub.2 are hydrogen or a .beta.-glucuronide group of the formula ##STR2## provided at least one of R.sub.1 and R.sub.2 is a .beta.-glucuronide group.
    Type: Grant
    Filed: March 31, 1995
    Date of Patent: October 8, 1996
    Assignee: Eli Lilly and Company
    Inventors: Barbara S. Briggs, Milton J. Zmijewski, Jr.
  • Biotransformation of glycopeptide antibiotics
    Patent number: 5534420
    Abstract: New glycopeptides prepared by biotransformation of a vancomycin-type antibiotic by an Acinomadura citrea culture (NRRL 18382), which are useful intermediates, and methods of preparing the biotransformed intermediates by adding a vancomycin-type glycopeptide to a growing culture of Actinomadura citrea NRRL 18382 and continuing fermentation under submerged aerobic conditions, are provided.
    Type: Grant
    Filed: May 18, 1995
    Date of Patent: July 9, 1996
    Assignee: Eli Lilly and Company
    Inventors: Manuel Debono, Robert M. Logan, Gary G. Marconi, R. Michael Molloy, Milton J. Zmijewski, Jr.
  • Phthalyl amidase-producing Xanthobacter agilis
    Patent number: 5532161
    Abstract: Phthalyl amidase is an enzyme previously unknown in the art that catalyzes removal of the phthalyl moiety from phthalyl-containing amides. The current invention provides 2 phthalyl amidase, 2 method for producing it by culturing the natural organism from which the activity was identified, and methods for using the phthalyl amidase to remove the phthalyl moiety from phthalyl-containing amides. The ezyme is isolated from Xanthobacter agilis.
    Type: Grant
    Filed: May 22, 1995
    Date of Patent: July 2, 1996
    Assignee: Eli Lilly and Company
    Inventors: Barbara S. Briggs, Milton J. Zmijewski, Jr.
  • Removal of phthalyl groups from amides and esters using an amidase isolated from Xanthobacter Agilis
    Patent number: 5532149
    Abstract: Phthalyl amidase is an enzyme previously unknown in the art that catalyzes removal of the phthalyl moiety from phthalyl-containing amides. The current invention provides a phthalyl amidase, a method for producing it by culturing the natural organism from which the activity was identified, and methods for using the phthalyl amidase to remove the phthalyl moiety from phthalyl-containing amides. The enzyme is isolated from Xanthobacter agilis.
    Type: Grant
    Filed: May 22, 1995
    Date of Patent: July 2, 1996
    Assignee: Eli Lilly and Company
    Inventors: Barbara S. Briggs, Milton J. Zmijewski, Jr.
  • Enzyme from microbial source: phthalyl amidase
    Patent number: 5445959
    Abstract: Phthalyl amidase is an enzyme previously unknown in the art that catalyzes removal of the phthalyl moiety from phthalyl-containing amides. The current invention provides said phthalyl amidase, means for producing it by culturing the natural organism from which the activity was identified, and methods for using said phthalyl amidase to remove the phthalyl moiety from phthalyl-containing amides.
    Type: Grant
    Filed: July 15, 1994
    Date of Patent: August 29, 1995
    Assignee: Eli Lilly and Company
    Inventors: Barbara S. Briggs, Milton J. Zmijewski, Jr.
  • Enantiomerically selective biocatalyzed acylation
    Patent number: 5057607
    Abstract: An enantiomerically selective process for acylating racemic 3-amino azetidinone intermediates is provided using penicillin G amidase(acylase) as biocatalyst.
    Type: Grant
    Filed: October 2, 1990
    Date of Patent: October 15, 1991
    Assignee: Eli Lilly and Company
    Inventors: Milton J. Zmijewski, Jr., Jeffrey N. Levy
  • Process for producing antibiotic A47934
    Patent number: 4880735
    Abstract: Improved fermentation process for producing the Gram-positive antibiotic A47934 which comprises cultivating a new strain of Streptomyces toyocaensis, NRRL 18112, and a biologically purified culture of this microorganism are provided.
    Type: Grant
    Filed: September 24, 1986
    Date of Patent: November 14, 1989
    Assignee: Eli Lilly and Company
    Inventors: Jeffrey T. Fayerman, Michael D. Jones, Karl H. Michel, Raymond C. Yao, Milton J. Zmijewski
  • Process for producing the A-21978C antibiotics
    Patent number: 4800157
    Abstract: Improved fermentation process for producing the gram-positive A-21978C antibiotics which comprises cultivating a new strain of Streptomyces roseosporus, NRRL 15998, and the biologically purified culture of this microorganism are provided.
    Type: Grant
    Filed: September 9, 1985
    Date of Patent: January 24, 1989
    Assignee: Eli Lilly and Company
    Inventors: Tom E. Eaton, Lynda M. Ford, Otis W. Godfrey, Jr., Mary L. B. Huber, Milton J. Zmijewski, Jr.