Patents by Inventor Milton Manowitz

Milton Manowitz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5039702
    Abstract: Userful as antimicrobial agents in aqeuous systems are .alpha.-halo.beta.-(substituted)thioacrylonitriles of the formula ##STR1## wherein X represents Cl, Br or I and R represents a lower alkyl, aryl, aralkyl, heterocyclo, or a thiocarbonyl group. The configuration about the double bond may be E or Z or a mixture thereof. These compounds provide effective control of microbial growth. The derivatives of formula I are economically prepared from acrylonitrile via a three-step process involving (a) halogenation, (b) dehydrohalogenation and (c) nucleophilic-type displacement. Except for those compounds wherein X is bromo and R is methyl or phenyl, the compounds of formula I are not mentioned in the prior art.
    Type: Grant
    Filed: April 14, 1989
    Date of Patent: August 13, 1991
    Assignee: Givaudan Corporation
    Inventors: Alyce Brandman, Milton Manowitz, Albert I. Rachlin
  • Patent number: 4841063
    Abstract: This disclosure relates to a novel class of 2-alkyl-3-haloisothiazolium salts. These salts have been found to be useful in controlling the growth of bacteria and fungi. They have also been found to be useful intermediates in the preparation of novel and known antibacterial and antifungal compounds.
    Type: Grant
    Filed: January 31, 1984
    Date of Patent: June 20, 1989
    Assignee: Givaudan Corporation
    Inventors: Joseph A. Virgilio, Milton Manowitz, Emanuel Heilweil
  • Patent number: 4508908
    Abstract: This disclosure relates to a novel class of 2-alkyl-3-haloisothiazolium salts. These salts have been found to be useful in controlling the growth of bacteria and fungi. They have also been found to be useful intermediates in the preparation of novel and known antibacterial and antifungal compounds.
    Type: Grant
    Filed: September 29, 1980
    Date of Patent: April 2, 1985
    Assignee: Givaudan Corporation
    Inventors: Joseph A. Virgilio, Milton Manowitz, Emanuel Heilweil
  • Patent number: 4328347
    Abstract: This disclosure relates to a novel class of 2-alkyl-3-haloisothiazolium salts. These salts have been found to be useful in controlling the growth of bacteria and fungi. They have also been found to be useful intermediates in the preparation of novel and known antibacterial and antifungal compounds.
    Type: Grant
    Filed: September 25, 1980
    Date of Patent: May 4, 1982
    Assignee: Givaudan Corporation
    Inventors: Joseph A. Virgilio, Milton Manowitz, Emanuel Heilweil
  • Patent number: 4281136
    Abstract: This disclosure relates to a novel class of 2-alkyl-3-haloisothiazolium salts. These salts have been found to be useful in controlling the growth of bacteria and fungi. They have also been found to be useful intermediates in the preparation of novel and known antibacterial and antifungal compounds.
    Type: Grant
    Filed: October 16, 1978
    Date of Patent: July 28, 1981
    Assignee: Givaudan Corporation
    Inventors: Joseph A. Virgilio, Milton Manowitz, Emanuel Heilweil
  • Patent number: 4262127
    Abstract: This disclosure relates to a novel class of 3-alkoxy-2-alkylisothiazolium salts. These salts have been found to be useful in controlling the growth of bacteria and fungi. They have also been found to be useful intermediates in the preparation of known antibacterial and antifungal compounds.
    Type: Grant
    Filed: April 16, 1979
    Date of Patent: April 14, 1981
    Assignee: Givaudan Corporation
    Inventors: Joseph A. Virgilio, Milton Manowitz, Emanuel Heilweil
  • Patent number: 4247712
    Abstract: There is disclosed methods and compositions for inhibiting or preventing the growth of microorganisms in aqueous systems wherein the growth is inhibited or prevented by the presence of an effective amount of a 2-chloro-3-oxobutyramide derivative.
    Type: Grant
    Filed: November 8, 1979
    Date of Patent: January 27, 1981
    Assignees: Givaudan Corporation, Hoffmann-La Roche Inc.
    Inventors: Harold A. Brandman, Milton Manowitz, David L. Coffen
  • Patent number: 4220577
    Abstract: Novel iodopropargyl pyridyl and picolinyl ethers and thioethers are effective antifungal agents. They find special utility in paint for protecting finished paint films from fungal attack.
    Type: Grant
    Filed: April 20, 1979
    Date of Patent: September 2, 1980
    Assignee: Givaudan Corporation
    Inventors: Harold A. Brandman, Joachim E. Freudewald, Milton Manowitz, Edward J. Nikawitz, Frederick H. Sharpell, Jr.
  • Patent number: 4217363
    Abstract: Methods and compositions for inhibiting or preventing the growth of microorganisms in aqueous systems wherein the growth is inhibited or prevented by the presence of an effective amount of .alpha.-chloro-.beta.-aminocrotonamide.
    Type: Grant
    Filed: August 17, 1978
    Date of Patent: August 12, 1980
    Assignees: Givaudan Corporation, Hoffmann-La Roche Inc.
    Inventors: Harold A. Brandman, Milton Manowitz, David L. Coffen
  • Patent number: 4214002
    Abstract: There is disclosed methods and compositions for inhibiting or preventing the growth of microorganisms in aqueous systems wherein the growth is inhibited or prevented by the presence of an effective amount of a 2-chloro-3-oxobutyramide derivative.
    Type: Grant
    Filed: August 17, 1978
    Date of Patent: July 22, 1980
    Assignees: Givaudan Corporation, Hoffmann-La Roche Inc.
    Inventors: Harold A. Brandman, Milton Manowitz, David L. Coffen
  • Patent number: 4206229
    Abstract: Methods and compositions for inhibiting or preventing the growth of microorganisms in aqueous systems wherein the growth is inhibited or prevented by the presence of an effective amount of .alpha.-bromo-.beta.-aminocrotononitrile.
    Type: Grant
    Filed: August 17, 1978
    Date of Patent: June 3, 1980
    Assignees: Givaudan Corporation, Hoffmann-La Roche Inc.
    Inventors: Harold A. Brandman, Milton Manowitz, David L. Coffen
  • Patent number: 4199600
    Abstract: Methods and compositions for inhibiting or preventing the growth of microorganisms in aqueous systems wherein the growth is inhibited or prevented by the presence of an effective amount of an .alpha.-halo-.beta.-aminocrotonic acid ester.
    Type: Grant
    Filed: August 17, 1978
    Date of Patent: April 22, 1980
    Assignees: Givaudan Corporation, Hoffmann-La Roche Inc.
    Inventors: Harold A. Brandman, Milton Manowitz, David L. Coffen
  • Patent number: 4170704
    Abstract: Novel iodopropargyl pyridyl and picolinyl ethers and thioethers are effective antifungal agents. They find special utility in paint for protecting finished paint films from fungal attack.
    Type: Grant
    Filed: April 20, 1978
    Date of Patent: October 9, 1979
    Assignee: Givaudan Corporation
    Inventors: Harold A. Brandman, Joachim E. Freudewald, Milton Manowitz, Edward J. Nikawitz, Frederick H. Sharpell, Jr.
  • Patent number: 4085062
    Abstract: U.V. absorbing compositions containing substituted N,N'-bis-aromaticformamidines and the use thereof as sun-screening agents.
    Type: Grant
    Filed: November 24, 1976
    Date of Patent: April 18, 1978
    Assignee: Givaudan Corporation
    Inventors: Joseph A. Virgilio, Milton Manowitz
  • Patent number: 4021471
    Abstract: Novel substituted formamidines are useful as ultraviolet light absorbers, the formamidines being characterized by the formula: ##STR1## wherein: R.sub.1 represents an alkyl group containing one to five carbon atoms;B is selected from the group consisting of H, OH, Cl or alkoxy;R.sub.2 represents a phenyl group or an alkyl group containing one to nine carbon atoms;A is selected from the group consisting of H, carboalkoxy, alkoxy, alkyl, dimethylamino and halogen.D is selected from the group consisting of H, methoxy and chlorine.
    Type: Grant
    Filed: April 18, 1974
    Date of Patent: May 3, 1977
    Assignee: Givaudan Corporation
    Inventors: Joseph A. Virgilio, Milton Manowitz
  • Patent number: 3932654
    Abstract: The present invention relates to processes and compositions for inhibiting or preventing the growth of microorganisms in aqueous systems and formulations, by the addition thereto of dialkyl bromonitromalonates.
    Type: Grant
    Filed: May 22, 1974
    Date of Patent: January 13, 1976
    Assignee: Givaudan Corporation
    Inventors: Harold A. Brandman, Milton Manowitz, William E. Newman