Patents by Inventor Milton T. W. Hearn
Milton T. W. Hearn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20200188878Abstract: The present invention provides methods of designing molecularly imprinted polymers (MIPs) which have applications in extracting bioactive compounds from a range of bioprocessing feedstocks and wastes. The present invention is further directed to MIPs designed by the methods of the present invention.Type: ApplicationFiled: July 11, 2019Publication date: June 18, 2020Inventors: Milton T. W. Hearn, Steven Langford, Kellie Louise Tuck, Simon Harris, Reinhard Ingemar Boysen, Victoria Tamara Perchyonok, Basil Danylec, Lachlan Schwarz, Jamil Chowdhury
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Publication number: 20160288090Abstract: The present invention provides methods of designing molecularly imprinted polymers (MIPs) which have applications in extracting bioactive compounds from a range of bioprocessing feedstocks and wastes. The present invention is further directed to MIPs designed by the methods of the present invention.Type: ApplicationFiled: February 8, 2016Publication date: October 6, 2016Applicants: Commonwealth Scientific and Industrial Research Organisation, Monash UniversityInventors: Milton T. W. Hearn, Steven Langford, Kellie Louise Tuck, Simon Harris, Reinhard Ingemar Boysen, Victoria Tamara Perchyonok, Basil Danylec, Lachlan Schwarz, Jamil Chowdhury
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Patent number: 8748582Abstract: The present invention relates generally to affinity ligands and chemical affinity ligand-matrix conjugates for use as chromatographic adsorbents and methods which utilize the adsorbents in the purification of proteins by affinity chromatography. The affinity ligand-matrix conjugates of the present invention comprise ligands of general formula (I): wherein m represents an integer from 0-2, n represents an integer from 0-6, p represents an integer from 0-4, R1 represents H or C1-3 alkyl, R2 is an optional substituent, and X is the position at which the ligand is immobilized, optionally via a linker.Type: GrantFiled: October 15, 2010Date of Patent: June 10, 2014Assignee: Monash UniversityInventors: Milton T W Hearn, Anjali Makarand Bhagwat, William Roy Jackson, Simon John Mountford
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Publication number: 20120225962Abstract: The present invention relates to methods of preparing molecularly imprinted polymers (MIPs) which facilitate chemical hydrolysis and more particularly the hydrolysis of chemical substrates which possess hydrolytically labile bonds such as peptides and proteins. The present invention is thus directed to MIPs designed to possess hydrolytic activity, methods for preparing such MIPs and uses of the MIPs.Type: ApplicationFiled: August 5, 2010Publication date: September 6, 2012Applicant: MONASH UNIVERSITYInventors: Milton T.W. Hearn, Jamil M. Chowdhury, Reinhard Ingemar Boysen, Yididya B. Banti
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Publication number: 20120052757Abstract: The present invention provides methods of designing molecularly imprinted polymers (MIPs) which have applications in extracting bioactive compounds from a range of bioprocessing feedstocks and wastes. The present invention is further directed to MIPs designed by the methods of the present invention.Type: ApplicationFiled: January 29, 2010Publication date: March 1, 2012Applicant: MONASH UNIVERSITYInventors: Milton T. W. Hearn, Steven Langford, Kellie Louise Tuck, Simon Harris, Reinhard Ingemar Boysen, Victoria Tamara Perchyonok, Basil Danylec, Lachlan Schwarz, Jamil Chowdhury
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Publication number: 20080108144Abstract: The invention provides improved sample preparation techniques as will as improved methods of analysis of samples. The techniques include a method of preparing a sample of MALDI-TOF analysis comprising applying a material having a liquid component to a carrier, removing at least a portion of the liquid component, and applying a MALDI matrix over the material to be analysed. In other embodiments, the sample preparation techniques include digestion of peptides prior to analysis by MALDI-TOF, which may be done in the presence of a surfactant, and sandwiching a sample for analysis between layers of MALDI matrix on a sample carrier.Type: ApplicationFiled: May 27, 2005Publication date: May 8, 2008Inventors: Muhammad A. Alam, Donald K. Bowden, Reinhard I. Boysen, Milton T.W. Hearn
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Patent number: 6294174Abstract: Peptides immunologically related to proteins expressed by a viral agent, having a sequence of amino acids ordered by means of the protein informational analysis techniques using the Fourier transform method with reference to the amino acid sequence of a target antigen against which antibodies are desired to be formed, or lymphocytes desired to be directed. The sequence has in the Fourier spectrum, one or more frequencies of practically the same value as the frequency of frequencies characteristic of the target antigen.Type: GrantFiled: November 16, 1994Date of Patent: September 25, 2001Assignees: Monash University, Centre National de la Recherche ScientifiqueInventors: Velibor Krsmanovic, Irena Cosic, Jean-Michel Biquard, Milton T. W. Hearn
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Patent number: 5470826Abstract: Polypeptides exhibiting an inhibitory action over follitropin are disclosed. These polypeptides are designated follitropin suppressing proteins, or "FSP's," and range in size from 30 to 60 kD as determined by SDS-PAGE. Uses for FSP's, including regulation of fertility and as immunogens, are disclosed.Type: GrantFiled: November 3, 1993Date of Patent: November 28, 1995Assignees: Biotechnology Australia Pty Ltd., Monash University, Monash Medical Centre, St. Vincents Institute of Medical ResearchInventors: David M. De Kretser, Henry G. Burger, Milton T. W. Hearn, David M. Milne-Robertson, Richard E. H. Wettenhall, Robert I. McLachlan, Fiona De Vos
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Patent number: 5364837Abstract: A protein which satisfies all the biological criteria which are characteristic of inhibin has been isolated from a gonadal source. The purification and characterization of inhibin and the use of the purified material to raise antibodies, the use of inhibin and said antisera in a quantative radioimmunoassay, and application in vitro and in vivo of inhibin and antibody to inhibin, are described. There is provided a purified protein, inhibin characterized in that the apparent molecular weight as determined by SDS-PAGE is 56,000.+-.1,000, the isoelectric point is in the range 6.9-7.3, and the protein can bind specifically to Concanavalin A-Sepharose. Moreover, the protein includes two subunits, characterized in that their apparent molecular weights as determined by SDS-PAGE are 44,000.+-.3,000 and 14,000.+-.2,000, respectively. Furthermore, the isoelectric point of the 44,000 molecular weight sub-unit is in the range of 6.0-7.0. In addition, the N-terminal amino acid sequence of the two subunits are described.Type: GrantFiled: August 3, 1989Date of Patent: November 15, 1994Assignees: Biotechnology Australia Pty. Ltd, Monash University, St. Vincent's Institute of Medical Research, Monash Medical CenterInventors: Henry G. Burger, David M. de Kretser, John K. Findlay, Francis J. Morgan, Milton T. W. Hearn, David M. Milne-Robertson, Robert G. Forage
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Patent number: 5102807Abstract: A protein which satisfies all the biological criteria which are characteristic of inhibin has been isolated from a gonadal source. The purification and characterization of inhibin and the use of the purified material to raise antibodies, the use of inhibin and said antisera in a quantative radioimmunoassay, and applications in vitro and in vivo of inhibin and antibody to inhibin, are described.There is provided a purified protein, inhibin, characterised in thata. the apparent molecular weight as determined by SDS-PAGE is 56,000.+-.1,000b. the isoelectric point is in the range 6.9-7.3c. the protein can bind specifically to Concanavalin A-Sepharosed the protein consists of two sub-units, characterized in thati. their apparent molecular weights as determined by SDS-PAGE are 44,000.+-.3,000 and 14,000.+-.2,000 respectively.ii. the isoelectric point of the 44,000 molecular weight sub-unit is in the range 6.0-7.0iii. the N-terminal amino acid sequences of the two sub-units are as described hereine.Type: GrantFiled: April 11, 1989Date of Patent: April 7, 1992Assignees: Biotechnology Australia Pty Ltd., Monash University, St. Vincent's Institute of Medical Research, Monash Medical CentreInventors: Henry G. Burger, David M. de Kretser, John K. Findlay, Francis J. Morgan, Milton T. W. Hearn, David Milne-Robertson, Robert G. Forage, Richard E. H. Weitenhall
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Patent number: 4330440Abstract: The invention relates to the carbonylation of cross linked substituted and unsubstituted polysaccharides, their copolymers with macroporous synthetic polymers, macroporous synthetic polymers and rigid supports with pendant hydroxyalkyl groups. The carbonylated product can be used to prepare an affinity chromatography matrix which remains an uncharged species at varying pH's. The carbonylated product is also useful for the preparation of other compounds: Typical polysaccharides are agarose, starch, dextran, cellulose and regenerated cellulose, typical macroporous synthetic polymers are acrylamides, acrylates and methacrylates, typical rigid supports are silica beads coated with hydroxy alkyl groups and typical cabonylating agents are N,N'-carbonyl diimidazole; N,N'carbonyl di-1,2,3-benzotriazole; and N,N'-carbonyl di-1,2,4-triazole.Type: GrantFiled: March 10, 1980Date of Patent: May 18, 1982Assignee: Development Finance Corporation of New ZealandInventors: John S. Ayers, Geoffrey S. Bethell, William S. Hancock, Milton T. W. Hearn
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Patent number: 4279724Abstract: Methods are described for the generation of natural pH gradients in layers of granulated gels using mixtures of amphoteric or amphoteric non-amphoteric buffer reagents. Because of the favorable characteristics of these flat bed systems, high voltage gradients (20-50 V/cm) can be used for the electrofocusing experiments. Linear or step pH gradients can be formed depending on the choice of buffer system used. Buffer systems, suitable for the preparative electrofocusing of proteins over the pI ranges of 4.0-6.0, 4.5-8.0, 5.0-8.5 and 6.0-8.5 are described.Type: GrantFiled: July 18, 1979Date of Patent: July 21, 1981Inventors: Milton T. W. Hearn, Ross L. Prestidge
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Patent number: 4224439Abstract: Carbonylation of a polysaccharide and the product of that carbonylation. The carbonylated product can be used to prepare an affinity chromatography matrix which is an uncharged species of varying pH's. The carbonylated product is also useful for the preparation of other compounds. Typical polysaccharides are agarose, starch, dextran, cellulose and regenerated cellulose and typical carbonylating agents are N,N'-carbonyl diimidazole; N,N' carbonyl di-1,2,3-benzotriazole; and N,N'-carbonyl di-1,2,4-triazole.Type: GrantFiled: February 2, 1978Date of Patent: September 23, 1980Assignee: Development Finance Corporation of New ZealandInventors: John S. Ayers, Geoffrey S. Bethell, William S. Hancock, Milton T. W. Hearn