Patents by Inventor Milton T. W. Hearn

Milton T. W. Hearn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20160288090
    Abstract: The present invention provides methods of designing molecularly imprinted polymers (MIPs) which have applications in extracting bioactive compounds from a range of bioprocessing feedstocks and wastes. The present invention is further directed to MIPs designed by the methods of the present invention.
    Type: Application
    Filed: February 8, 2016
    Publication date: October 6, 2016
    Applicants: Commonwealth Scientific and Industrial Research Organisation, Monash University
    Inventors: Milton T. W. Hearn, Steven Langford, Kellie Louise Tuck, Simon Harris, Reinhard Ingemar Boysen, Victoria Tamara Perchyonok, Basil Danylec, Lachlan Schwarz, Jamil Chowdhury
  • Patent number: 8748582
    Abstract: The present invention relates generally to affinity ligands and chemical affinity ligand-matrix conjugates for use as chromatographic adsorbents and methods which utilize the adsorbents in the purification of proteins by affinity chromatography. The affinity ligand-matrix conjugates of the present invention comprise ligands of general formula (I): wherein m represents an integer from 0-2, n represents an integer from 0-6, p represents an integer from 0-4, R1 represents H or C1-3 alkyl, R2 is an optional substituent, and X is the position at which the ligand is immobilized, optionally via a linker.
    Type: Grant
    Filed: October 15, 2010
    Date of Patent: June 10, 2014
    Assignee: Monash University
    Inventors: Milton T W Hearn, Anjali Makarand Bhagwat, William Roy Jackson, Simon John Mountford
  • Publication number: 20120225962
    Abstract: The present invention relates to methods of preparing molecularly imprinted polymers (MIPs) which facilitate chemical hydrolysis and more particularly the hydrolysis of chemical substrates which possess hydrolytically labile bonds such as peptides and proteins. The present invention is thus directed to MIPs designed to possess hydrolytic activity, methods for preparing such MIPs and uses of the MIPs.
    Type: Application
    Filed: August 5, 2010
    Publication date: September 6, 2012
    Applicant: MONASH UNIVERSITY
    Inventors: Milton T.W. Hearn, Jamil M. Chowdhury, Reinhard Ingemar Boysen, Yididya B. Banti
  • Publication number: 20120052757
    Abstract: The present invention provides methods of designing molecularly imprinted polymers (MIPs) which have applications in extracting bioactive compounds from a range of bioprocessing feedstocks and wastes. The present invention is further directed to MIPs designed by the methods of the present invention.
    Type: Application
    Filed: January 29, 2010
    Publication date: March 1, 2012
    Applicant: MONASH UNIVERSITY
    Inventors: Milton T. W. Hearn, Steven Langford, Kellie Louise Tuck, Simon Harris, Reinhard Ingemar Boysen, Victoria Tamara Perchyonok, Basil Danylec, Lachlan Schwarz, Jamil Chowdhury
  • Publication number: 20080108144
    Abstract: The invention provides improved sample preparation techniques as will as improved methods of analysis of samples. The techniques include a method of preparing a sample of MALDI-TOF analysis comprising applying a material having a liquid component to a carrier, removing at least a portion of the liquid component, and applying a MALDI matrix over the material to be analysed. In other embodiments, the sample preparation techniques include digestion of peptides prior to analysis by MALDI-TOF, which may be done in the presence of a surfactant, and sandwiching a sample for analysis between layers of MALDI matrix on a sample carrier.
    Type: Application
    Filed: May 27, 2005
    Publication date: May 8, 2008
    Inventors: Muhammad A. Alam, Donald K. Bowden, Reinhard I. Boysen, Milton T.W. Hearn
  • Patent number: 6294174
    Abstract: Peptides immunologically related to proteins expressed by a viral agent, having a sequence of amino acids ordered by means of the protein informational analysis techniques using the Fourier transform method with reference to the amino acid sequence of a target antigen against which antibodies are desired to be formed, or lymphocytes desired to be directed. The sequence has in the Fourier spectrum, one or more frequencies of practically the same value as the frequency of frequencies characteristic of the target antigen.
    Type: Grant
    Filed: November 16, 1994
    Date of Patent: September 25, 2001
    Assignees: Monash University, Centre National de la Recherche Scientifique
    Inventors: Velibor Krsmanovic, Irena Cosic, Jean-Michel Biquard, Milton T. W. Hearn
  • Patent number: 5470826
    Abstract: Polypeptides exhibiting an inhibitory action over follitropin are disclosed. These polypeptides are designated follitropin suppressing proteins, or "FSP's," and range in size from 30 to 60 kD as determined by SDS-PAGE. Uses for FSP's, including regulation of fertility and as immunogens, are disclosed.
    Type: Grant
    Filed: November 3, 1993
    Date of Patent: November 28, 1995
    Assignees: Biotechnology Australia Pty Ltd., Monash University, Monash Medical Centre, St. Vincents Institute of Medical Research
    Inventors: David M. De Kretser, Henry G. Burger, Milton T. W. Hearn, David M. Milne-Robertson, Richard E. H. Wettenhall, Robert I. McLachlan, Fiona De Vos
  • Patent number: 5364837
    Abstract: A protein which satisfies all the biological criteria which are characteristic of inhibin has been isolated from a gonadal source. The purification and characterization of inhibin and the use of the purified material to raise antibodies, the use of inhibin and said antisera in a quantative radioimmunoassay, and application in vitro and in vivo of inhibin and antibody to inhibin, are described. There is provided a purified protein, inhibin characterized in that the apparent molecular weight as determined by SDS-PAGE is 56,000.+-.1,000, the isoelectric point is in the range 6.9-7.3, and the protein can bind specifically to Concanavalin A-Sepharose. Moreover, the protein includes two subunits, characterized in that their apparent molecular weights as determined by SDS-PAGE are 44,000.+-.3,000 and 14,000.+-.2,000, respectively. Furthermore, the isoelectric point of the 44,000 molecular weight sub-unit is in the range of 6.0-7.0. In addition, the N-terminal amino acid sequence of the two subunits are described.
    Type: Grant
    Filed: August 3, 1989
    Date of Patent: November 15, 1994
    Assignees: Biotechnology Australia Pty. Ltd, Monash University, St. Vincent's Institute of Medical Research, Monash Medical Center
    Inventors: Henry G. Burger, David M. de Kretser, John K. Findlay, Francis J. Morgan, Milton T. W. Hearn, David M. Milne-Robertson, Robert G. Forage
  • Patent number: 5102807
    Abstract: A protein which satisfies all the biological criteria which are characteristic of inhibin has been isolated from a gonadal source. The purification and characterization of inhibin and the use of the purified material to raise antibodies, the use of inhibin and said antisera in a quantative radioimmunoassay, and applications in vitro and in vivo of inhibin and antibody to inhibin, are described.There is provided a purified protein, inhibin, characterised in thata. the apparent molecular weight as determined by SDS-PAGE is 56,000.+-.1,000b. the isoelectric point is in the range 6.9-7.3c. the protein can bind specifically to Concanavalin A-Sepharosed the protein consists of two sub-units, characterized in thati. their apparent molecular weights as determined by SDS-PAGE are 44,000.+-.3,000 and 14,000.+-.2,000 respectively.ii. the isoelectric point of the 44,000 molecular weight sub-unit is in the range 6.0-7.0iii. the N-terminal amino acid sequences of the two sub-units are as described hereine.
    Type: Grant
    Filed: April 11, 1989
    Date of Patent: April 7, 1992
    Assignees: Biotechnology Australia Pty Ltd., Monash University, St. Vincent's Institute of Medical Research, Monash Medical Centre
    Inventors: Henry G. Burger, David M. de Kretser, John K. Findlay, Francis J. Morgan, Milton T. W. Hearn, David Milne-Robertson, Robert G. Forage, Richard E. H. Weitenhall
  • Patent number: 4330440
    Abstract: The invention relates to the carbonylation of cross linked substituted and unsubstituted polysaccharides, their copolymers with macroporous synthetic polymers, macroporous synthetic polymers and rigid supports with pendant hydroxyalkyl groups. The carbonylated product can be used to prepare an affinity chromatography matrix which remains an uncharged species at varying pH's. The carbonylated product is also useful for the preparation of other compounds: Typical polysaccharides are agarose, starch, dextran, cellulose and regenerated cellulose, typical macroporous synthetic polymers are acrylamides, acrylates and methacrylates, typical rigid supports are silica beads coated with hydroxy alkyl groups and typical cabonylating agents are N,N'-carbonyl diimidazole; N,N'carbonyl di-1,2,3-benzotriazole; and N,N'-carbonyl di-1,2,4-triazole.
    Type: Grant
    Filed: March 10, 1980
    Date of Patent: May 18, 1982
    Assignee: Development Finance Corporation of New Zealand
    Inventors: John S. Ayers, Geoffrey S. Bethell, William S. Hancock, Milton T. W. Hearn
  • Patent number: 4279724
    Abstract: Methods are described for the generation of natural pH gradients in layers of granulated gels using mixtures of amphoteric or amphoteric non-amphoteric buffer reagents. Because of the favorable characteristics of these flat bed systems, high voltage gradients (20-50 V/cm) can be used for the electrofocusing experiments. Linear or step pH gradients can be formed depending on the choice of buffer system used. Buffer systems, suitable for the preparative electrofocusing of proteins over the pI ranges of 4.0-6.0, 4.5-8.0, 5.0-8.5 and 6.0-8.5 are described.
    Type: Grant
    Filed: July 18, 1979
    Date of Patent: July 21, 1981
    Inventors: Milton T. W. Hearn, Ross L. Prestidge
  • Patent number: 4224439
    Abstract: Carbonylation of a polysaccharide and the product of that carbonylation. The carbonylated product can be used to prepare an affinity chromatography matrix which is an uncharged species of varying pH's. The carbonylated product is also useful for the preparation of other compounds. Typical polysaccharides are agarose, starch, dextran, cellulose and regenerated cellulose and typical carbonylating agents are N,N'-carbonyl diimidazole; N,N' carbonyl di-1,2,3-benzotriazole; and N,N'-carbonyl di-1,2,4-triazole.
    Type: Grant
    Filed: February 2, 1978
    Date of Patent: September 23, 1980
    Assignee: Development Finance Corporation of New Zealand
    Inventors: John S. Ayers, Geoffrey S. Bethell, William S. Hancock, Milton T. W. Hearn