Patents by Inventor Min A. Xiang

Min A. Xiang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted spiroheterocycles
    Patent number: 7825111
    Abstract: The invention is directed to nonpeptide substituted spiroheterobenzazepine of Formula I, which are useful as vasopressin receptor antagonists for treating conditions associated with vasopressin receptor activity such as those involving increased vascular resistance and cardiac insufficiency, including congestive heart failure, hyponatremia, and hypertension. Pharmaceutical compositions comprising a compound of Formula I and methods of treating conditions such as hypertension, congestive heart failure, cardiac insufficiency, coronary vasospasm, cardiac ischemia, liver cirrhosis, hyponatremia, renal vasospasm, renal failure, diabetic nephropathy, cerebral edema, cerebral ischemia, stroke, thrombosis, or water retention are also disclosed.
    Type: Grant
    Filed: September 19, 2007
    Date of Patent: November 2, 2010
    Assignee: Janssen Pharmaceutica NV
    Inventors: Min A. Xiang, Mona Patel, Philip Rybczynski, Joseph Gunnet, Keith T. Demarest, Richard Look, Bruce Maryanoff, Michael J. Costanzo, Stephen C. Yabut
  • Substituted spiroheterocycles
    Patent number: 7825110
    Abstract: The invention is directed to nonpeptide substituted spiroheterobenzazepine of Formula I, which are useful as vasopressin receptor antagonists for treating conditions associated with vasopressin receptor activity such as those involving increased vascular resistance and cardiac insufficiency, including congestive heart failure, hyponatremia, and hypertension. Pharmaceutical compositions comprising a compound of Formula I and methods of treating conditions such as hypertension, congestive heart failure, cardiac insufficiency, coronary vasospasm, cardiac ischemia, liver cirrhosis, hyponatremia, renal vasospasm, renal insufficiency, renal failure, diabetic nephropathy, cerebral edema, cerebral ischemia, stroke, thrombosis, or water retention are also disclosed.
    Type: Grant
    Filed: September 19, 2007
    Date of Patent: November 2, 2010
    Assignee: Janssen Pharmaceutica NV
    Inventors: Min A. Xiang, Mona Patel, Philip Rybczynski, Joseph Gunnet, Keith T. Demarest, Richard Look, Bruce Maryanoff, Michael J. Costanzo, Stephen C. Yabut
  • Nonpeptide substituted spirobenzoazepines as vasopressin antagonists
    Patent number: 7691844
    Abstract: The invention is directed to nonpeptide substituted benzodiazepines of Formula I, wherein A, X, n, R1, R2, R3, R4, R5, a and b are as described in the specification, which are useful as vasopressin receptor antagonists for treating conditions associated with vasopressin receptor activity such as those involving increased vascular resistance and cardiac insufficiency. Pharmaceutical compositions comprising a compound of Formula I and methods of treating conditions such as hypertension, congestive heart failure, cardiac insufficiency, coronary vasospasm, cardiac ischemia, liver cirrhosis, renal vasospasm, renal failure, cerebral edema and ischemia, stroke, thrombosis, or water retention are also disclosed.
    Type: Grant
    Filed: October 16, 2006
    Date of Patent: April 6, 2010
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Robert H. K. Chen, Min A. Xiang
  • Nonpeptide substituted spirobenzoazepines as vasopressin antagonists
    Patent number: 7365062
    Abstract: The invention is directed to nonpeptide substituted benzodiazepines of Formula I, wherein A, X, n, R1, R2, R3, R4, R5, a and b are as described in the specification, which are useful as vasopressin receptor antagonists for treating conditions associated with vasopressin receptor activity such as those involving increased vascular resistance and cardiac insufficiency. Pharmaceutical compositions comprising a compound of Formula I and methods of treating conditions such as hypertension, congestive heart failure, cardiac insufficiency, coronary vasospasm, cardiac ischemia, liver cirrhosis, renal vasospasm, renal failure, cerebral edema and ischemia, stroke, thrombosis, or water retention are also disclosed.
    Type: Grant
    Filed: November 29, 2006
    Date of Patent: April 29, 2008
    Assignee: Ortho McNeil Pharmaceutical, Inc.
    Inventors: Robert H. K. Chen, Min A. Xiang
  • Nonpeptide substituted spirobenzoazepines as vasopressin antagonists
    Patent number: 7238687
    Abstract: The invention is directed to nonpeptide substituted benzodiazepines of Formula I, wherein A, X, n, R1, R2, R3, R4, R5, a and b are as described in the specification, which are useful as vasopressin receptor antagonists for treating conditions associated with vasopressin receptor activity such as those involving increased vascular resistance and cardiac insufficiency. Pharmaceutical compositions comprising a compound of Formula I and methods of treating conditions such as hypertension, congestive heart failure, cardiac insufficiency, coronary vasospasm, cardiac ischemia, liver cirrhosis, renal vasospasm, renal failure, cerebral edema and ischemia, stroke, thrombosis, or water retention are also disclosed.
    Type: Grant
    Filed: May 19, 2003
    Date of Patent: July 3, 2007
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Robert H. K. Chen, Min A. Xiang
  • Nonpeptide substituted spirobenzoazepines as vasopressin antagonists
    Patent number: 7001898
    Abstract: The invention is directed to nonpeptide substituted benzodiazepines of Formula I, wherein A, X, n, R1, R2, R3, R4, R5, a and b are as described in the specification, which are useful as vasopressin receptor antagonists for treating conditions associated with vasopressin receptor activity such as those involving increased vascular resistance and cardiac insufficiency. Pharmaceutical compositions comprising a compound of Formula I and methods of treating conditions such as hypertension, congestive heart failure, cardiac insufficiency, coronary vasospasm, cardiac ischemia, liver cirrhosis, renal vasospasm, renal failure, cerebral edema and ischemia, stroke, thrombosis, or water retention are also disclosed.
    Type: Grant
    Filed: July 2, 2001
    Date of Patent: February 21, 2006
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Robert H. K. Chen, Min A. Xiang
  • Cyclobutene derivatives useful as antagonists of the motilin receptor
    Patent number: 6667309
    Abstract: The compounds of formula I are useful in treating gastrointestinal disorders associated with antagonizing the motilin receptor. The compounds compete with erythromycin and motilin for the motilin receptor. In addition the compounds are antagonists of the contractile smooth muscle response to those ligands.
    Type: Grant
    Filed: March 12, 2002
    Date of Patent: December 23, 2003
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Robert H. Chen, Min A. Xiang
  • Cyclopentene derivatives useful as antagonists of the motilin receptor
    Patent number: 6624165
    Abstract: The compounds of formula I are useful in treating gastrointestinal disorders associated with antagonizing the motilin receptor. The compounds compete with erythromycin and motilin for the motilin receptor. In addition the compounds are antagonists of the contractile smooth muscle response to those ligands.
    Type: Grant
    Filed: April 9, 2002
    Date of Patent: September 23, 2003
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Robert H. Chen, Min A. Xiang
  • Nonpeptide substituted spirobenzoazepines as vasopressin antagonists
    Publication number: 20030045517
    Abstract: The invention is directed to nonpeptide substituted benzodiazepines of Formula I, 1
    Type: Application
    Filed: July 2, 2001
    Publication date: March 6, 2003
    Inventors: Robert H.K. Chen, Min A. Xiang
  • Novel cyclopentene derivatives useful as antagonists of the motilin receptor
    Publication number: 20020111484
    Abstract: The compounds of formula I are useful in treating gastrointestinal disorders associated with antagonizing the motilin receptor. The compounds compete with erythromycin and motilin for the motilin receptor. In addition the compounds are antagonists of the contractile smooth muscle response to those ligands.
    Type: Application
    Filed: April 9, 2002
    Publication date: August 15, 2002
    Inventors: Robert H. Chen, Min A. Xiang
  • Novel cyclobutene derivatives useful as antagonists of the motilin receptor
    Publication number: 20020103238
    Abstract: The compounds of formula I are useful in treating gastrointestinal disorders associated with antagonizing the motilin receptor. The compounds compete with erythromycin and motilin for the motilin receptor. In addition the compounds are antagonists of the contractile smooth muscle response to those ligands.
    Type: Application
    Filed: March 12, 2002
    Publication date: August 1, 2002
    Inventors: Robert H. Chen, Min A. Xiang
  • Cyclohexene derivatives useful as antagonists of the motilin receptor
    Patent number: 6423714
    Abstract: The compounds of formula I are useful in treating gastrointestinal disorders associated with antagonizing the motilin receptor. The compounds compete with erythromycin and motilin for the motilin receptor. In addition the compounds are antagonists of the contractile smooth muscle response to those ligands.
    Type: Grant
    Filed: March 9, 2001
    Date of Patent: July 23, 2002
    Assignee: Ortho McNeil-Pharmaceutical, Inc..
    Inventors: Robert H. Chen, Min A. Xiang
  • Cyclopentene compounds useful as antagonists of the motilin receptor
    Patent number: 6392040
    Abstract: The compounds of formula I are useful in treating gastrointestinal disorders associated with antagonizing the motilin receptor. The compounds compete with erythromycin and motilin for the motilin receptor. In addition the compounds are antagonists of the contractile smooth muscle response to those ligands.
    Type: Grant
    Filed: March 9, 2001
    Date of Patent: May 21, 2002
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Robert H. Chen, Min A. Xiang
  • Cyclobutene derivatives useful as antagonists of the motilin receptor
    Patent number: 6384031
    Abstract: The compounds of formula I are useful in treating gastrointestinal disorders associated with antagonizing the motilin receptor. The compounds compete with erythromycin and motilin for the motilin receptor. In addition the compounds are antagonists of the contractile smooth muscle response to those ligands.
    Type: Grant
    Filed: March 9, 2001
    Date of Patent: May 7, 2002
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Robert H. Chen, Min A. Xiang
  • Novel cyclohexene derivatives useful as antagonists of the motilin receptor
    Publication number: 20020002192
    Abstract: The compounds of formula I are useful in treating gastrointestinal disorders associated with antagonizing the motilin receptor. The compounds compete with erythromycin and motilin for the motilin receptor. In addition the compounds are antagonists of the contractile smooth muscle response to those ligands.
    Type: Application
    Filed: March 9, 2001
    Publication date: January 3, 2002
    Inventors: Robert H. Chen, Min A Xiang
  • Novel cyclobutene derivatives useful as antagonists of the motilin receptor
    Publication number: 20010056106
    Abstract: The compounds of formula I are useful in treating gastrointestinal disorders associated with antagonizing the motilin receptor. The compounds compete with erythromycin and motilin for the motilin receptor. In addition the compounds are antagonists of the contractile smooth muscle response to those ligands.
    Type: Application
    Filed: March 9, 2001
    Publication date: December 27, 2001
    Inventors: Robert H. Chen, Min A. Xiang
  • Novel cyclopentene derivatives useful as antagonists of the motilin receptor
    Publication number: 20010041701
    Abstract: The compounds of formula I are useful in treating gastrointestinal disorders associated with antagonizing the motilin receptor. The compounds compete with erythromycin and motilin for the motilin receptor. In addition the compounds are antagonists of the contractile smooth muscle response to those ligands.
    Type: Application
    Filed: March 9, 2001
    Publication date: November 15, 2001
    Inventors: Robert H. Chen, MIn A. Xiang