Abstract: A peptide for treating rheumatoid arthritis and use thereof are provided, and a peptide consisting of an amino acid sequence of SEQ ID NO: 1, SEQ ID NO: 3, or SEQ ID NO: 5 or a polynucleotide encoding the same, and a pharmaceutical composition for treating rheumatoid arthritis or a health functional food composition for improving rheumatoid arthritis, each including the peptide, are provided.

Abstract: The present disclosure provides methods and systems for detecting multiple different nucleotides in a sample. In particular, the disclosure provides for detection of multiple different nucleotides in a sample utilizing fewer detection moieties than the number of nucleotides being detected and/or fewer imaging events than the number of nucleotides being detected.

Abstract: The present disclosure relates generally to certain compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions provided herein may be used for the treatment or prevention of a Retroviridae infection, including an HIV infection.

Abstract: The present invention provides phthalate free impact resistant polypropylene copolymer and methods of preparation, which are produced directly from the polymerization reactor system without further compounding of components which significantly alters the physical properties of the resulting polymer. The copolymer according to the present invention possesses both low temperature ductility and high flexural modulus, wherein said polymer is produced in the presence of a phthalate free ZN catalyst comprising urea component.

Abstract: A technique maintains online access to data stored in a plurality of storage devices during a hardware upgrade in which the plurality of storage devices moves between storage processor enclosures. The technique involves providing, from the plurality of storage devices, online access to the data while each storage device of the plurality of storage devices resides in a first storage processor enclosure. The technique further involves providing, from the plurality of storage devices, online access to the data while the plurality of storage devices is moved from the first storage processor enclosure to a second storage processor enclosure (e.g., transferring each storage devices one by one before triggering a rebuild process). The technique further involves providing, from the plurality of storage devices, online access to the data while each storage device of the plurality of storage devices resides in the second storage processor enclosure.

Abstract: An electronic package of which the manufacturing method is to dispose an electronic element on a circuit portion, encapsulate the electronic element with an Ajinomoto build-up film (ABF) used as an encapsulating layer, form a wiring layer on the encapsulating layer, and form a conductive via in the encapsulating layer. Therefore, the wiring layer can be well bonded onto the encapsulating layer as the ABF material is used as the encapsulating layer.

Abstract: A package substrate is provided and includes a core board body and a first circuit structure and a second circuit structure disposed on opposite sides of the core board body, where the number of wiring layers of the second circuit structure is different from the number of wiring layers of the first circuit structure, so that the package substrate is asymmetrical. The first circuit structure and the second circuit structure are designed according to the thickness and coefficient of thermal expansion of the first dielectric layer of the first circuit structure and the second dielectric layer of the second circuit structure, so as to prevent the problem of warping from occurring to the package substrate.

Abstract: A Far UV C excimer bulb assembly including an excimer bulb, and a curved filter external to and separated from the excimer bulb. The curved filter being hafnium based and including an arc. The excimer bulb emits radiation in a plurality of wavelengths substantially comprising Far UV C. The curved filter having a cut-off wavelength of 234 nm and adapted to block substantially all wavelengths of UV C radiation longer than 234 nm. The excimer bulb is positioned at least partially and centered within the arc so that the majority of the Far UV C wavelengths of radiation pass perpendicularly through the curved filter. The assembly may further include a mirror which may also be curved, and plated onto the exterior surface of the excimer bulb.

Abstract: A semiconductor package is disclosed, which comprises a substrate, one or more dies on a first side of the substrate, and a plurality of interconnect structures having a first pitch and coupled to a second side of the substrate. The interconnect structures may attach the substrate to a board. The substrate may include a first interconnect layer having a second pitch. The first interconnect layer may be coupled to the one or more dies through second one or more interconnect layers. Third one or more interconnect layers between the first interconnect layer and the interconnect structures may translate the first pitch to the second pitch. The substrate may include a recess on a section of the second side of the substrate. The semiconductor package may further include one or more components within the recess and attached to the second side of the substrate.

Abstract: A large scale bioreactor system includes a stainless steel large scale bioreactor having at least one valve assembly, and an aseptic connector assembly coupled to the at least one valve assembly of the bioreactor. A perfusion device includes an Alternating Tangential Filtration assembly with an autoclaved valve assembly coupled to the aseptic connector assembly, and the aseptic connector assembly includes one of a triclamp aseptic connector or a hose assembly. Single use feed containers include an aseptic connector assembly.

Abstract: Programmable components of a quantum processor may be selectively programmed using digital to analog converters (DACs). A DAC with a first stage and a second stage and first and second quantum flux parametron (OFF) loops galvanically coupled to and extending from a respective one of the first stage and the second stage is discussed. The first stage has a first storage loop interrupted by a first Josephson junction and an interface for communicating with an external component. The second stage has a second storage loop interrupted by a second Josephson junction, the second storage loop galvanically coupled to the first storage loop, the first Josephson junction and the second Josephson junction coupled in series to a first control line. A method of loading flux quanta into targeted DAC stages is also discussed.

Abstract: A user input device may include a shaft carried by a housing and having a first end extending outwardly beyond the housing for manipulation by a user and a second end within the housing. A set of one or more sensors may be carried by the housing to sense shaft movement. A first contact member may be within the housing, and a spring may be coupled between the first contact member and the shaft to urge the first contact member and the shaft apart. A motor may be carried within the housing and may have a rotatable output extending therefrom. A second contact member may be coupled to the rotatable output and may be in contact with the first contact member to be selectively moveable based upon motor rotation to set a spring compression and thereby set a return-to-center bias for the shaft while being manipulated.

Abstract: A user input device may include a shaft carried by a housing and having a first end extending outwardly beyond the housing for manipulation by a user and a second end within the housing. A set of one or more sensors may be carried by the housing to sense shaft movement. A first contact member may be within the housing, and a spring may be coupled between the first contact member and the shaft to urge the first contact member and the shaft apart. A motor may be carried within the housing and may have a rotatable output extending therefrom. A second contact member may be coupled to the rotatable output and may be in contact with the first contact member to be selectively moveable based upon motor rotation to set a spring compression and thereby set a return-to-center bias for the shaft while being manipulated.

Abstract: A thumbstick user input device may include a shaft carried by a housing and having an upper end extending outwardly beyond the housing for manipulation by the user's thumb and a lower end within the housing. Sensors may be carried by the housing to sense shaft movement. A first contact member may be within the housing, and a spring may be between the first contact member and the shaft to urge the first contact member and the shaft apart. A motor may be carried at a bottom of the housing and may have a rotatable output extending upwardly therefrom. A second contact member may be coupled to the rotatable output and in contact with the first contact member to be selectively moveable upward or downward based upon motor rotation to set a spring compression and thereby set a return-to-center bias for the shaft while being manipulated by the user's thumb.

Abstract: An apparatus for holding a cover in a closed orientation substantially covering a chassis face of a unit; the unit containing equipment in an equipment volume; the equipment volume being partially bounded by the chassis face; includes: a positioning structure coupling the cover with the unit for selectively situating the cover in the closed orientation or in an other orientation; and a latching structure configured for latchingly engaging the chassis face and the cover for holding the cover in the closed orientation when the latching structure is in a first orientation. The latching structure does not engage the chassis face and the cover when the latching structure is in a second orientation. The latching structure is situated substantially entirely outside the equipment volume.

Abstract: A computing device includes a Mini DisplayPort or other standardized plug and port connection that is fully internalized within the full device housing. The port can be affixed or coupled to a printed circuit board, with a display cable having a mating plug that is plugged into the port. To prevent the inadvertent uncoupling of the plug from the port, one or more clips, clamps, fixtures, or other cable retention components can hold the cable and/or plug in place at or near where the plug inserts into the Mini DisplayPort or other standardized communication port. Added stability to the cable can also be provided at or near such location.

Abstract: A computing device includes a Mini DisplayPort or other standardized plug and port connection that is fully internalized within the full device housing. The port can be affixed or coupled to a printed circuit board, with a display cable having a mating plug that is plugged into the port. To prevent the inadvertent uncoupling of the plug from the port, one or more clips, clamps, fixtures, or other cable retention components can hold the cable and/or plug in place at or near where the plug inserts into the Mini DisplayPort or other standardized communication port. Added stability to the cable can also be provided at or near such location.

Abstract: Electrical connections that provide a highly manufacturable, well-shielded path from a cable to a printed circuit board. One example provides a path that includes a card and a connector. Conductors in a cable may be attached to a card. The card may be shielded with a ground plane on one or more sides and edges. The card may insert into a connector that may be attached to a printed circuit board. The connector may include a shield that may have a top portion that forms electrical contact with a ground plane on a top of a card inserted in the connector. The connector may have an opening for accepting the card that is defined by the top portion of the shield and a plurality of rows of contacts. The rows of contacts may include an outer row of ground contacts, and an inner row of signal contacts.

Abstract: A system and method for metering fuel is provided which includes a fuel supply line and a metering valve in fluid connection with the fuel supply line to control a flow of fuel through the fuel supply line. The valve is movable into a closed position to block a primary flow of fuel and create a leakage fuel flow in the fuel supply line downstream of the metering valve. The system also includes a venturi apparatus fluidly coupled to the fuel supply line upstream of the metering valve. The venturi apparatus is further coupled to the fuel supply line downstream of the metering valve to direct the leakage fuel flow out of the fuel supply line.

Abstract: A system and method for metering fuel is provided which includes a fuel supply line and a metering valve in fluid connection with the fuel supply line to control a flow of fuel through the fuel supply line. The valve is movable into a closed position to block a primary flow of fuel and create a leakage fuel flow in the fuel supply line downstream of the metering valve. The system also includes a venturi apparatus fluidly coupled to the fuel supply line upstream of the metering valve. The venturi apparatus is further coupled to the fuel supply line downstream of the metering valve to direct the leakage fuel flow out of the fuel supply line.