Abstract: A pre-prodrug, comprising a drug, e.g., doxorubicin, which has off-target toxicity (e.g., cardiotoxicity) with respect to its antineoplastic activity, and an amine functionality of the drug incorporated into a disubstituted maleimide (DMI). The pre-prodrug may be linked to a targeting or de-targeting agent or a polar modulator, e.g., charged ligand, amino acid, peptide, etc., to increase therapeutic index. The pre-prodrug is hydrolyzed to the prodrug, having a disubstituted maleamic acid (DMA). A polar modulator such as glutamic acid prevents cellular uptake of the prodrug, but not the doxorubicin drug released from the prodrug after dissociation. The prodrug is pH sensitive, and below pH 7.0, tends to cleave to form free drug and cyclized maleic anhydride. Tumor environments tend to be more acidic, e.g., pH 6.8, than cardiac tissue, e.g., pH 7.4, and therefore the heart is spared while the drug is selectively released within a tumor.

Abstract: The present disclosure discloses a video interface conversion device that includes a first and a second interface transmission circuit, a color conversion circuit and an image compression circuit. The first and the second interface transmission circuit are respectively electrically coupled to an image source and a display terminal. The second interface transmission circuit negotiates a maximum output bandwidth with the display terminal such that the first interface transmission circuit compares an input data bandwidth of a data signal received from the image source and the maximum output bandwidth. When the maximum output bandwidth is smaller than the input data bandwidth, an image compression and/or a color coding conversion is performed on the data signal, and the data signal having the processed input data bandwidth being smaller than or equal to the maximum output bandwidth is further transmitted by the second interface transmission circuit to the display terminal.

Abstract: This application discloses an interactive service processing method and system, a device, and a storage medium, and belongs to the field of computer technologies. The method includes acquiring a video stream and interactive information corresponding to the video stream, the interactive information comprising an interactive timestamp and interactive data; determining a transmission mode corresponding to the interactive information, the transmission mode comprising one of transmission based on a network channel and transmission with a video stream fragment as a medium; transmitting the video stream to a target terminal; and transmitting the interactive information to the target terminal based on the transmission mode corresponding to the interactive information, the target terminal being configured to process interactive service on the video stream according to the interactive timestamp and the interactive data in the interactive information.

Abstract: A method for switching audio-visual interfaces and a circuit system are provided. The circuit system is disposed in a sink device. A protocol layer circuit of each of audio-visual interfaces in the sink device includes a status and control data channel control module, which is used to respond to the signals sent by the video sources continuously when the sink device is connected with audio-visual sources via the audio-visual interfaces. The multiple video sources can accordingly send FRL (fixed rate link) signals to the sink device in response to responses made by the sink device. The protocol layer circuit includes an FRL audio-visual packet detection module that starts to detect a rate of an FRL and resolve audio-visual packets for obtaining audio-visual data for the audio-visual interface that the sink device switches to.

Abstract: A device having color resists pattern and method for manufacturing are disclosed. The device includes a substrate, at least two color resist layers. The at least color resist layers are formed on the curved and construct a visible pattern, wherein at a boundary of the color resist pattern, the at least two color resist layers form a ramp structure and each of the at least two color resist layers contacts the substrate; and the ramp structure is formed in sequential order by one exposure process, one removal process and one baking process of the at least two color resist layers.

Abstract: A method for switching audio-visual interfaces and a circuit system are provided. The circuit system is disposed in a sink device. A protocol layer circuit of each of audio-visual interfaces in the sink device includes a status and control data channel control module, which is used to respond to the signals sent by the video sources continuously when the sink device is connected with audio-visual sources via the audio-visual interfaces. The multiple video sources can accordingly send FRL (fixed rate link) signals to the sink device in response to responses made by the sink device. The protocol layer circuit includes an FRL audio-visual packet detection module that starts to detect a rate of an FRL and resolve audio-visual packets for obtaining audio-visual data for the audio-visual interface that the sink device switches to.

Abstract: A device having a color photo resist pattern includes a 3D substrate, at least one color photo resist layer and at least one circuit pattern layer. The at least one color photo resist layer is formed on said 3D substrate and forms a visual pattern together. The at least one circuit pattern layer is formed on said visual pattern formed by said at least one color photo resist layer.

Abstract: The present invention discloses a signal enhancement relay apparatus is provided. A display data channel stretching circuit includes a direct and an indirect channels. A snooper circuit is disposed at the direct channel. The indirect channel includes a master and a slave paths having a master and a slave transmission circuits disposed thereon. The direct channel is selected under a default passive mode such that a snooper link bridging handler circuit is enabled to monitor a display data transmission on the direct path through the snooper circuit, to perform a channel link bridging process corresponding to a data enhancement transmission channel accordingly.

Abstract: A detection circuit and a wake-up method are provided. The detection circuit is adapted to a high definition multimedia interface (HDMI) receiver that enters a power-saving mode in a fixed rate link (FRL) mode to detect whether or not an HDMI transmitter starts to transmit video packets through the FRL. The detection circuit includes a signal detection circuit detecting whether or not signal exists on the FRL and an FRL packet determination circuit determining whether or not the FRL packets are the video packets according to a variable value characteristic of the video packets and/or a fixed value characteristic of gap packets. An existence of the signal on the FRL indicates an existence of FRL packets on the FRL. When the FRL packets are the video packets, the FRL packet determination circuit wakes the HDMI receiver from the power-saving mode to resolve the video packets and display videos.

Abstract: A detection circuit and a wake-up method are provided. The detection circuit is adapted to a high definition multimedia interface (HDMI) receiver that enters a power-saving mode in a fixed rate link (FRL) mode to detect whether or not an HDMI transmitter starts to transmit video packets through the FRL. The detection circuit includes a signal detection circuit detecting whether or not signal exists on the FRL and an FRL packet determination circuit determining whether or not the FRL packets are the video packets according to a variable value characteristic of the video packets and/or a fixed value characteristic of gap packets. An existence of the signal on the FRL indicates an existence of FRL packets on the FRL. When the FRL packets are the video packets, the FRL packet determination circuit wakes the HDMI receiver from the power-saving mode to resolve the video packets and display videos.

Abstract: This application discloses an interactive service processing method and system, a device, and a storage medium, and belongs to the field of computer technologies. The method includes acquiring a video stream and interactive information corresponding to the video stream, the interactive information comprising an interactive timestamp and interactive data; determining a transmission mode corresponding to the interactive information, the transmission mode comprising one of transmission based on a network channel and transmission with a video stream fragment as a medium; transmitting the video stream to a target terminal; and transmitting the interactive information to the target terminal based on the transmission mode corresponding to the interactive information, the target terminal being configured to process interactive service on the video stream according to the interactive timestamp and the interactive data in the interactive information.

Abstract: The present invention discloses a signal enhancement relay apparatus is provided. A display data channel stretching circuit includes a direct and an indirect channels. A snooper circuit is disposed at the direct channel. The indirect channel includes a master and a slave paths having a master and a slave transmission circuits disposed thereon. The direct channel is selected under a default passive mode such that a snooper link bridging handler circuit is enabled to monitor a display data transmission on the direct path through the snooper circuit, to perform a channel link bridging process corresponding to a data enhancement transmission channel accordingly.

Abstract: A substrate having film type pattern and the manufacturing method, the substrate having film type pattern includes: a substrate; at least film type pattern layer which is allocated on the substrate; and a peripheral pattern layer which is allocated around the film type pattern layer.

Abstract: The present disclosure discloses a video interface conversion device that includes a first and a second interface transmission circuit, a color conversion circuit and an image compression circuit. The first and the second interface transmission circuit are respectively electrically coupled to an image source and a display terminal. The second interface transmission circuit negotiates a maximum output bandwidth with the display terminal such that the first interface transmission circuit compares an input data bandwidth of a data signal received from the image source and the maximum output bandwidth. When the maximum output bandwidth is smaller than the input data bandwidth, an image compression and/or a color coding conversion is performed on the data signal, and the data signal having the processed input data bandwidth being smaller than or equal to the maximum output bandwidth is further transmitted by the second interface transmission circuit to the display terminal.

Abstract: A pre-prodrug, comprising a drug, e.g., doxorubicin, which has off-target toxicity (e.g., cardiotoxicity) with respect to its antineoplastic activity, and an amine functionality of the drug incorporated into a disubstituted maleimide (DMI). The pre-prodrug may be linked to a targeting or de-targeting agent or a polar modulator, e.g., charged ligand, amino acid, peptide, etc., to increase therapeutic index. The pre-prodrug is hydrolyzed to the prodrug, having a disubstituted maleamic acid (DMA). A polar modulator such as glutamic acid prevents cellular uptake of the prodrug, but not the doxorubicin drug released from the prodrug after dissociation. The prodrug is pH sensitive, and below pH 7.0, tends to cleave to form free drug and cyclized maleic anhydride. Tumor environments tend to be more acidic, e.g., pH 6.8, than cardiac tissue, e.g., pH 7.4, and therefore the heart is spared while the drug is selectively released within a tumor.

Abstract: The disclosure illustrates a curve-shaped mask, a curved device having color resist pattern and method for manufacturing the same. The curved device includes a curved substrate and at least two color resist layers. The at least two color resist layers are formed on the curved substrate, and construct a visible pattern together. The curved device is manufactured by a curve-shaped mask, which is a metal-containing material layer formed on the curved substrate and is visible.

Abstract: The present disclosure relates to a solvent-containing dry film and a method for applying a dry film on a substrate. The dry film includes a carrier and a resin layer. The resin layer contains a resin composition and a solvent and the solvent is present in a total amount of at least 5 wt % based on the total weight of the resin layer. The dry film of the present invention can be applied onto a substrate without the use of a prior art vacuum lamination apparatus. The application process is simple and is more cost-efficient than the prior art techniques.

Abstract: A device having a color photo resist pattern includes a 3D substrate, at least one color photo resist layer and at least one circuit pattern layer. The at least one color photo resist layer is formed on said 3D substrate and forms a visual pattern together. The at least one circuit pattern layer is formed on said visual pattern formed by said at least one color photo resist layer.

Abstract: A method for forming a 3D pattern structure on a 3D substrate and a device having color resist pattern is disclosed. The disclosure uses the fitting aids to apply pressure on the thin-film mask to paste on the 3D substrate. After the template device had formed, send the template device to the exposure machine, and then the high resolution photo-resist pattern is made on the 3D substrate. After a Lift-off procedure, the thin-film pattern is formed and the photo-resist is removed.

Abstract: The disclosure provides an ultra-fine copper mesh for a display and a touch panel, comprising a transparent substrate, having an upper surface and a lower surface with respect to the upper surface; and a first copper electrode layer comprising a first pure copper deposited film, having a top surface and a bottom surface with respect to the top surface, wherein the bottom surface of the first pure copper deposited film is disposed on the upper surface of the transparent substrate; and a first antireflective conductive film, disposed on the top surface of the first pure copper deposited film, the first antireflective conductive film comprises a cuprous oxide (Cu2O). After the first antireflective conductive film is subjected to an exposure developing process, the first copper deposited film layer of the first copper electrode layer and the first antireflective conductive film are simultaneously subjected to an over-etching process on the transparent substrate to form together at least one mesh pattern.