Abstract: A skin-permeable peptide, a derivative thereof, or a fragment thereof of the present disclosure effectively delivers skin bioactive molecules deep into the skin tissues through assembly or fusion methods, thereby providing outstanding skin permeability as well as excellent skin residual effect of bioactive materials to maximize bioactive efficacy. Accordingly, the skin-permeable peptide, derivative thereof, or fragment thereof may be widely used as an active ingredient of a pharmaceutical composition for external use and a functional cosmetic composition that target skin tissues including mucous membranes.

Abstract: The tumor tissue-penetrating peptide of the present invention, a derivative thereof, or a fragment thereof effectively delivers a drug deep into tumor or tissues through an assembling or fusion method and exhibits not only excellent penetration activity into biomembranes but also excellent tumor selectivity to maximize anticancer activity, and thus the tumor tissue-penetrating peptide, a derivative thereof, or a fragment thereof can be widely utilized as an active ingredient in pharmaceutical compositions for treatment or prevention of and compositions for diagnosis of cancer or angiogenesis-related diseases, which exhibit improved tumor selectivity and delivery ability to tumor and target cancer tissues or cells including biomembranes.

Abstract: A heat block assembly and an organic compound synthesizing apparatus using the heat block assembly are provided. The heat block assembly includes one or more heat blocks provided with grooves in which reaction containers are inserted, and a temperature adjustor for adjusting the temperature of the heat block.

Abstract: This invention relates to a technology of modifying low-molecular-weight bioactive substances with short in vivo half-life and low stability in order to achieve a stable and efficient in vivo delivery thereof. More specifically, the present invention relates to a stable bioactive substance-blood protein conjugate, wherein a low-molecular-weight bioactive substance is ex vivo conjugated with a specific functional group on a blood protein through a reactive group, the low-molecular-weight bioactive substance is available as a drug for treatment and prevention in mammals including human and selected from the group consisting of a natural substance; and a method of a stable and efficient in vivo delivery of the low-molecular-weight bioactive substance based on the use of the bioactive substance-blood protein conjugate.

Abstract: A heat block assembly and an organic compound synthesizing apparatus using the heat block assembly are provided. The heat block assembly includes one or more heat blocks provided with grooves in which reaction containers are inserted, and a temperature adjustor for adjusting the temperature of the heat block.