Abstract: A preparation method and applications of rejuvenated and regenerative fibroblasts, where the rejuvenated and regenerative fibroblasts are prepared from normal fibroblasts by inhibiting the JAK-STAT signaling pathway. The rejuvenated and regenerative fibroblasts are prepared by treating the target cells with a small molecular combination, a cytokine combination or a recombinant protein combination. This application further provides an application of the rejuvenated and regenerative fibroblasts in the reprogramming or rejuvenation of cells, tissues, organs and organisms.

Abstract: A method of regulating differentiation, dedifferentiation, transdifferentiation, rejuvenation, aging and apoptosis of target cells and uses thereof In the method, a gene or protein target involved in the JAK-STAT signaling pathway is regulated quantitatively or in a timing manner using a small molecular combination, a cytokine or recombinant protein combination, gene editing or transgenic technique to achieve the rejuvenation and/or obtain different lineages of cells. This application further provides applications of cell products generated in the method or their derivatives in the reprogramming and immunoregulation of cells, tissues, organs and organisms, construction of tissue engineering materials, repairing of injured, aged and degenerated mammalian tissues and organs and delaying and reversing of the aging process of cells, tissues, organs and organisms.

Abstract: The present application belongs to the field of chemical synthesis, and specifically relates to a six-membered ring-containing nucleoside compound and a preparation method thereof. The present application discloses a six-membered ring-containing nucleoside compound. The structural formula of the nucleoside compound 7 is: where R1 is selected from one of where R2 is hydroxyl or alkynyl.

Abstract: A fault root cause analysis method and apparatus are provided. The method includes: obtaining a first alarm event set, where the first alarm event set includes a plurality of alarm events; for a first alarm event in the first alarm event set, extracting a feature vector of the first alarm event, where a part of or all features of the feature vector are used to represent a relationship between the first alarm event and another alarm event in the first alarm event set; and determining, based on the feature vector of the first alarm event, whether the first alarm event is a root cause alarm event. In this application, whether the first alarm event is the root cause alarm event is determined based on a feature vector of the relationship between the first alarm event and the another alarm event, and the accuracy of fault root cause identification is improved.

Abstract: A packet generation method based on a server cluster and a load balancer, where the method includes receiving a client request packet, determining a destination server according to a preset load balancing policy, sending an Address Resolution Protocol (ARP) request packet according to the destination Internet Protocol (IP) address, obtaining an ARP response packet according to the ARP request packet, the initial Media Access Control (MAC) address is different from an actual MAC address of the destination server, and updating the destination IP address according to the initial MAC address to obtain an updated client request packet, where the updated client request packet includes the source IP address and an updated destination IP address. In this way, in a process of transmitting a packet, a source IP address of a client is detected on a network layer without changing a source IP address in a request packet.

Abstract: A liquid sensor for a diaper, and method of manufacturing the same are provided. The liquid sensor includes a plurality of electrochemical cells in series connection. Each of the plurality of electrochemical cells includes an anode, a cathode and a liquid-porous layer including an electrolyte solution. The liquid-porous layer electrically connects the anode to the cathode such that each cell has a respective predetermined potential difference across the cell. Two or more of the plurality of electrochemical cells are operable to be electrically connected by a liquid to form a single electrochemical cell having a potential difference lower than the sum of the predetermined potential differences of the two or more electrochemical cells.

Abstract: The present invention provides compounds as PPAR agonists and their application, involving a new class of peroxisome proliferator-activated receptor (PPAR) gamma receptor agonist, which can inhibit the production of mitochondrial reactive oxygen species, and most of which can readily cross the blood-brain barrier. The present invention also includes pharmaceutical uses of the compounds.

Abstract: Identifying network loops is disclosed including determining a first data packet having a time to live (TTL) that at least meets a first condition, the first data packet having a destination internet protocol (IP) address; within a time period after the determining of the first data packet, identifying a plurality of second data packets that are to be transmitted to the destination IP address; and determining whether a network loop exists for the destination IP address based on TTLs of the plurality of second data packets.

Abstract: A colorimetric sensor for detecting an analyte of interest that includes multiple surfaces and a molecularly imprinted polymer defining a cavity shaped to receive an analyte of interest. Each surface defines a void (e.g., a pore or a nanohole) and at least one surface defines a fluid inlet. The sensor is configured such that, when an analyte contacts the molecularly imprinted polymer and becomes disposed within the cavity, a wettability of at least one of the surfaces changes thereby to cause a detectable color change in the sensor. Optionally, the sensor may also include a metal layer at a bottom of each void or nanohole and outside a top of each void or nanohole for use as a plasmon resonance-type sensor.

Abstract: Certain populations of small cells present in adult human tissue can undergo activation/development to form human pluripotent stem cell populations. These small cells are generally less than six micrometers in diameter and are CD49f-positive, and are referred to herein as human early stage precursors or CD49f+ cells. Accordingly, provided are cell populations and compositions with enriched CD49f+ cells from adult human tissue samples and methods and compositions for promoting activation/development of these CD49f+ cells. Upon differentiation, the activated stem cells can be used for various therapeutic purposes.

Abstract: Network traffic processing includes: determining whether one or more packets of network traffic associated with a first public network address have been dropped, the first public network address being associated with a target host; in response to the determination that the one or more packets associated with the first public network address have been dropped, assigning a second public network address to the network traffic and generating a forwarding path corresponding to the second public network address, wherein the second public network address is configured to receive the network traffic, and wherein the forwarding path is configured to forward the network traffic received at the second public network address to the target host; and notifying a filtering device to transmit the network traffic to the second public network address and cause the network traffic to be forwarded to the target host according to the forwarding path.

Abstract: A breast pump including a container, a host unit disposed above and communicating with the container, an electric heating cup disposed at the front end of the host unit and communicating with the container, an electric heating element, and heat insulation. The electric heating cup includes an inner cover and an outer cover which are integrated. The electric heating element and the heat insulation are disposed between the inner cover and the outer cover. The heat insulation is disposed between the electric heating element and the outer cover. Positive and negative electrodes of the electric heating element are connected to conducting plates disposed in the inner side of the outer cover via connection wires. The conducting plates extend to the outer side of the outer cover and are in electric connection to contact chips disposed at the lower front end of the host unit.

Abstract: A display panel, a display terminal and a display motherboard are provided. The display panel includes a pixel defining layer, an inorganic barrier layer, an organic light-emitting material layer, and a thin film encapsulation structure. The pixel defining layer is provided with a plurality of openings distributed in an array. The inorganic barrier layer is disposed in a part of the openings at a periphery of the pixel defining layer, and has a plurality of first grooves spaced apart on a side thereof. The organic light-emitting material layer is disposed in the part of the openings and formed on the inorganic barrier layer. The thin film encapsulation structure is disposed on the pixel defining layer, and the thin film encapsulation structure is filled in the first grooves and covers the organic light-emitting material layer.

Abstract: A liquid sensor for a diaper, and method of manufacturing the same are provided. The liquid sensor includes a plurality of electrochemical cells in series connection. Each of the plurality of electrochemical cells includes an anode, a cathode and a liquid-porous layer including an electrolyte solution. The liquid-porous layer electrically connects the anode to the cathode such that each cell has a respective predetermined potential difference across the cell. Two or more of the plurality of electrochemical cells are operable to be electrically connected by a liquid to form a single electrochemical cell having a potential difference lower than the sum of the predetermined potential differences of the two or more electrochemical cells.

Abstract: A method for inducing differentiated cells into mesenchymal stem cells (MSCs), and combinations of regulatory targets thereof. The method includes performing a directional induction on the differentiated cells to prepare the mesenchymal stem cells. The directional induction includes treating cells by inhibiting the TGF-? signal pathway, inhibiting the activity of PKC, activating the WNT/?-catenin signal pathway and activating the cAMP signal pathway. By regulating corresponding signal pathways and/or enzymatic activities by stages, the differentiated cells are induced into the mesenchymal stem cells.

Abstract: A colorimetric sensor for detecting an analyte of interest that includes a metal layer disposed upon a substrate, a plurality of nanostructures, and a corresponding plurality of metal deposits spaced apart from the metal layer. The metal layer defines a plurality of holes, each nanostructure includes a first portion disposed within a respective hole, and each metal deposit is disposed upon a second portion of a respective nanostructure. The sensor also includes a molecularly imprinted polymer layer that may cover the metal layer, the nanostructures, and/or the metal deposits. The molecularly imprinted polymer layer defines a cavity shaped to receive the analyte of interest, and the sensor is configured such that, when an analyte contacts the molecularly imprinted polymer layer and becomes disposed within the cavity, an optical property of at least a portion of the sensor changes thereby to cause a detectable color change in and/or from the sensor.

Abstract: A system includes an Alice transmitting terminal, a wavelength division multiplexing (WDM) unit and a plurality of Bob terminals for receiving a plurality of photons of different wavelengths; the Alice terminal is connected with the plurality of Bob terminals by the WDM unit; the Alice terminal includes a multi-wavelength laser generation device, an attenuator, a first polarization beam splitter, a first beam combiner, a phase modulator, a first polarization controller and a second polarization controller; the WDM unit includes a wavelength selection device; each Bob terminal includes a second polarization controller, a third polarization controller, a fourth polarization controller, a third polarization beam splitter, a fourth polarization beam splitter, a second beam combiner, a third beam combiner, a first photon detector, a second photon detector, a third photon detector and a fourth photon detector.

Abstract: A colorimetric sensor for detecting an analyte of interest in a fluid sample includes a lamellar photonic material having alternating layers of a first polymer layer and a second polymer layer. Each first polymer layer can be a molecularly imprinted polymer defining a cavity shaped to receive an analyte of interest. The photonic material is configured such that, when an analyte contacts the photonic material and becomes disposed within a cavity of the molecularly imprinted polymer, a refractive property of the photonic material changes, causing a detectable color change in the sensor.

Abstract: Identifying network loops is disclosed including determining a first data packet having a time to live (TTL) that at least meets a first condition, the first data packet having a destination internet protocol (IP) address; within a time period after the determining of the first data packet, identifying a plurality of second data packets that are to be transmitted to the destination IP address; and determining whether a network loop exists for the destination IP address based on TTLs of the plurality of second data packets.

Abstract: Identifying network loops is disclosed including determining a first data packet having a time to live (TTL) that at least meets a first condition, the first data packet having a destination internet protocol (IP) address; within a time period after the determining of the first data packet, identifying a plurality of second data packets that are to be transmitted to the destination IP address; and determining whether a network loop exists for the destination IP address based on TTLs of the plurality of second data packets.