Abstract: A method for preparing a microsphere include steps of dissolving an active ingredient and a biodegradable polymer in an organic solvent to prepare a dispersed phase, dissolving a salt in water to prepare a continuous phase, mixing and stirring the dispersed phase and the continuous phase to form an emulsion, removing the organic solvent; and drying.

Abstract: There is provided is a big data-based autonomous flight drone system according to an exemplary embodiment of the present invention, which includes: a smart drone; a ground control system generating a remote control command for flight control of the smart drone; a drone IoT server which operates as a relay server for a communication connection between the smart drone and the ground control system, receives the remote control command from the ground control system so as to transfer the remote control command to the smart drone, and receives drone flight information and a camera image from the smart drone so as to transfer the drone flight information and the camera image to the ground control system; and an AI big data server which receives destination information and the drone flight information inputted in the ground control system, and generates a plurality of flight routes according to a preset criterion by interlocking with a database storing spatial information big data based on the destination informatio