Abstract: The present invention relates to a novel-structured nucleic acid complex having a blood-brain barrier penetration ability and a composition comprising same and, more specifically, to a nucleic acid complex in which a bioactive nucleic acid is complementarily bound to a carrier peptide nucleic acid modified to be generally positively charged, and to a composition for blood-brain barrier penetration comprising same. The nucleic acid complex according to the present invention can penetrate the blood-brain barrier at excellent efficiency, and especially, the conjugation of a drug into the nucleic acid complex increases the blood-brain barrier penetration ability of the drug, and thus is very useful in treatment or diagnosis of diseases.

Abstract: A smart nasometer according to an embodiment of the present invention includes: a hardware unit worn on a head of a user for measuring nasal and oral sounds and providing feedback for the user; and a computational unit for receiving and processing speech signals of the nasal and oral sounds measured by the hardware unit, wherein the hardware unit includes: a microphone unit for separately measuring the nasal and oral sounds in a non-touched state of the user's philtrum, wherein the computational unit includes: a nasalance adjustment unit for adjusting a nasalance of the nasal and oral sounds measured by the microphone unit.

Abstract: A smart nasometer according to an embodiment of the present invention includes: a hardware unit for mesmartasuring and feedbacking nasal and oral sounds worn by the user; and a computational unit for receiving a speech signal measured by the hardware unit and performing processing, wherein the hardware unit includes: a microphone unit for separating and measuring the nasal and oral speech signals in a non-touched state of the user's philtrum, wherein the operation unit includes: a nasalance adjustment unit for adjusting a nasalance of the speech signal measured by the microphone unit.