Abstract: The present invention relates to a pidolate salt and malate salt of a compound represented by a formula 1 with an excellent liquid-phase stability, solid-phase stability, water solubility, precipitation stability and hygroscopicity all together as a compound for preventing and treating diseases mediated by an acid pump antagonistic activity, as well as a method for preparing the same.

Abstract: The present invention relates to a pidolate salt and malate salt of a compound represented by a formula 1 with an excellent liquid-phase stability, solid-phase stability, water solubility, precipitation stability and hygroscopicity all together as a compound for preventing and treating diseases mediated by an acid pump antagonistic activity, as well as a method for preparing the same.

Abstract: The present invention relates to a use of a caspase inhibitor for alleviating or treating osteoarthritis.

Abstract: The present invention relates to a pidolate salt and malate salt of a compound represented by a formula 1 with an excellent liquid-phase stability, solid-phase stability, water solubility, precipitation stability and hygroscopicity all together as a compound for preventing and treating diseases mediated by an acid pump antagonistic activity, as well as a method for preparing the same.

Abstract: The present invention relates to a pidolate salt and malate salt of a compound represented by a formula 1 with an excellent liquid-phase stability, solid-phase stability, water solubility, precipitation stability and hygroscopicity all together as a compound for preventing and treating diseases mediated by an acid pump antagonistic activity, as well as a method for preparing the same.

Abstract: The present invention relates to a pidolate salt and malate salt of a compound represented by a formula 1 with an excellent liquid-phase stability, solid-phase stability, water solubility, precipitation stability and hygroscopicity all together as a compound for preventing and treating diseases mediated by an acid pump antagonistic activity, as well as a method for preparing the same.

Abstract: The present invention relates to a respirator without breathing resistance, which has an air inlet duct that passes through an inside and an outside of the respirator and that has asymmetrical electrodes and particle capturing plates formed on an inner surface of the air inlet duct; ozone removing element that removes ozone generated by micro-plasma; and high voltage dc-dc converter that provides high voltage to the asymmetrical electrodes. It employs asymmetrical electrodes and particle capturing plates to filter air without generating breathing resistance. When the respirator according to the present invention is used, safety of a wearer may be maintained in accordance with an environment and breathing may be smoothly performed even while introduction of pathogenic bacteria, viruses, fungi, spores, fine dust, or the like included in air may be effectively blocked. Accordingly, the respirator may be widely utilized to maintain the safety of the wearer in various environments.

Abstract: The present disclosure relates to a composition for injection, which comprises a pharmaceutically acceptable salt of a compound represented by Formula 1 and one or more selected from mannitol, trehalose, lactose and glucose as a stabilizing agent, having improved stability.

Abstract: The present disclosure relates to a composition for injection, which comprises a pharmaceutically acceptable salt of a compound represented by Formula 1 and one or more selected from mannitol, trehalose, lactose and glucose as a stabilizing agent, having improved stability.

Abstract: The present invention relates to a respirator without breathing resistance, which has an air inlet duct that passes through an inside and an outside of the respirator and that has asymmetrical electrodes and particle capturing plates formed on an inner surface of the air inlet duct; ozone removing element that removes ozone generated by micro-plasma; and high voltage dc-dc converter that provides high voltage to the asymmetrical electrodes. It employs asymmetrical electrodes and particle capturing plates to filter air without generating breathing resistance. When the respirator according to the present invention is used, safety of a wearer may be maintained in accordance with an environment and breathing may be smoothly performed even while introduction of pathogenic bacteria, viruses, fungi, spores, fine dust, or the like included in air may be effectively blocked. Accordingly, the respirator may be widely utilized to maintain the safety of the wearer in various environments.

Abstract: Provided is a method of fabricating a transistor. The method includes forming a fin portion protruding upward from a substrate, forming a device isolation pattern on the substrate to cover a lower portion of a sidewall of the fin portion, forming a trench in the device isolation pattern, the trench exposing a top surface and sidewalls of a channel region of the fin portion, and injecting a Group-IV element into the channel region of the fin portion to increase the volume of the channel region.

Abstract: Provided is a method of fabricating a transistor. The method includes forming a fin portion protruding upward from a substrate, forming a device isolation pattern on the substrate to cover a lower portion of a sidewall of the fin portion, forming a trench in the device isolation pattern, the trench exposing a top surface and sidewalls of a channel region of the fin portion, and injecting a Group-IV element into the channel region of the fin portion to increase the volume of the channel region.

Abstract: The present invention relates to an improved method of preparing adefovir dipivoxil of Formula 1. The method of the present invention is characterized by using dimethylsulfoxide as a reaction solvent, and comprises a process of preparing adefovir dipivoxil of Formula 1 by allowing adefovir of Formula 2 to react with chloromethylpivalate at a reaction temperature of 30 to 50° C. under the presence of dimethylsulfoxide and triethylamine solvents.

Abstract: The present invention relates to an improved method of preparing adefovir dipivoxil of Formula 1. The method of the present invention is characterized by using dimethylsulfoxide as a reaction solvent, and comprises a process of preparing adefovir dipivoxil of Formula 1 by allowing adefovir of Formula 2 to react with chloromethylpivalate at a reaction temperature of 30 to 50° C. under the presence of dimethylsulfoxide and triethylamine solvents.

Abstract: The present invention relates to a novel method of purifying adefovir dipivoxil of Formula 1. The purification method according to the present invention comprises the steps of dissolving impure adefovir dipivoxil containing byproducts generated during a synthetic reaction, salts thereof or complexes thereof in water or a water-containing mixed solvent; purifying the adefovir dipivoxil solution through a reverse-phase column; and adding a base to the purified adefovir dipivoxil solution and extracting the same with an organic solvent. Further, the present invention provides a method of preparing amorphous adefovir dipivoxil by removing the solvent from the high purity solution of adefovir dipivoxil represented by formula I purified by the above method.