Abstract: A fluid handling and cleaning circulation system includes a storage device storing circulation liquid, a circulating pipeline to circulate the circulation liquid, a filter device to filter the circulation liquid, and a purification separator to remove impurities from and to divide the circulation liquid into a recyclable flow body and an excitation flow body. The purification separator has a first outlet for outletting the excitation flow body, a second outlet for outletting the recyclable flow body to the filter device, and an inlet for inletting the circulation liquid. A nano excitation device is disposed downstream of the first outlet for exciting and nanolizing the excitation flow body. A flow control device pressurizes and accelerates the circulation liquid so that the circulation liquid flows at predetermined velocity and pressure from the storage device, through the filter device, the purification separator and the nano excitation device, and back to the storage device.