Abstract: Certain embodiments of the invention provide cell penetrating peptides. Certain embodiments of the invention provide methods and compositions for intracellular delivery. Certain embodiments of the invention provide methods and compositions for targeted delivery.

Abstract: Provided are antibodies that specifically bind to T-cell immunoglobulin domain and mucin domain 3 (Tim-3). The anti-Tim-3 antibodies can be used to treat, prevent or diagnose immune, cancerous, infectious diseases or other pathological disorders that may be modulated by Tim-3-mediated functions.

Abstract: Methods and compositions for quantifying the cellular concentration of cyclic adenosine monophosphate (cAMP), cyclic guanine monophosphate (cGMP), glutathione, glucose, and glutamine in a single cell include the use of conjugates and analogs in immunofluorescent assays for on-chip quantification. These metabolite immunofluorescent assays may be incorporated with proteomic assays for simultaneous single cell analysis of metabolites and proteins.

Abstract: In various embodiments an analytical method for profiling lactate (or other analyte) production in single cells, via the use of coupled enzyme reactions on surface-grafted resazurin/resofurin molecules is provided. Additionally surface-bound resazurin/resofurin that retains redox indicator activity as well as microfluidic devices comprising such sur-face-bound resazurin/resofurin indicators are provided.

Abstract: A submicron structure having a silica body defining a plurality of pores is described. The submicron body may be spherical or non-spherical, and may include a cationic polymer or co-polymer on the surface of said silica body. The submicron structure may further include an oligonucleotide and be used to deliver the oligonucleotide to a cell. The submicron structure may further include a therapeutic agent and be used to deliver the therapeutic agent to a cell. An oligonucleotide and therapeutic agent may be used together. For example, when the oligonucleotide is an siRNA, the composition may be used to decrease cellular resistance to the therapeutic agent by decreasing translation of a resistance gene.

Abstract: An apparatus comprises an optical signal generator configured to provide a first radiation comprising a first nominal carrier frequency and a second nominal carrier frequency, and provide a second radiation comprising a third nominal carrier frequency and a fourth nominal carrier frequency; an optical to electrical converter coupled to the optical signal generator and configured to: generate a first electrical current based on the first radiation and the second radiation without the second radiation passing through the Device under Test (DUT); and generate a second electrical current based on the first radiation and the second radiation after the second radiation passes through the DUT; and a data processor configured to determine a transfer function of the DUT at the third nominal carrier frequency and the fourth nominal carrier frequency based on the first electrical current and the second electrical current.

Abstract: A submicron structure having a silica body defining a plurality of pores is described. The submicron body may be spherical or non-spherical, and may include a cationic polymer or co-polymer on the surface of said silica body. The submicron structure may further include an oligonucleotide and be used to deliver the oligonucleotide to a cell. The submicron structure may further include a therapeutic agent and be used to deliver the therapeutic agent to a cell. An oligonucleotide and therapeutic agent may be used together. For example, when the oligonucleotide is an siRNA, the composition may be used to decrease cellular resistance to the therapeutic agent by decreasing translation of a resistance gene.

Abstract: An apparatus comprises an optical signal generator configured to provide a first radiation comprising a first nominal carrier frequency and a second nominal carrier frequency, and provide a second radiation comprising a third nominal carrier frequency and a fourth nominal carrier frequency; an optical to electrical converter coupled to the optical signal generator and configured to: generate a first electrical current based on the first radiation and the second radiation without the second radiation passing through the Device under Test (DUT); and generate a second electrical current based on the first radiation and the second radiation after the second radiation passes through the DUT; and a data processor configured to determine a transfer function of the DUT at the third nominal carrier frequency and the fourth nominal carrier frequency based on the first electrical current and the second electrical current.

Abstract: An apparatus comprises an optical detecting signal generator configured to provide an optical spectrum comprising two frequency carriers, the two frequency carriers having two different nominal carrier frequencies, and the output port of the optical detecting signal generator being further configured to be coupled to a device under test (DUT); an optical to electrical converter configured to generate a first electrical current based on the optical spectrum without the optical spectrum passing through the DUT; and generate a second electrical current based on the optical spectrum after the optical spectrum passes through the DUT; and a data processor coupled to the optical to electrical converter, the data processor being configured to determine a transfer function of the DUT at an average of the two different nominal carrier frequencies based on the first electrical current and the second electrical current.

Abstract: An apparatus comprises an optical detecting signal generator configured to provide an optical spectrum comprising two frequency carriers, the two frequency carriers having two different nominal carrier frequencies, and the output port of the optical detecting signal generator being further configured to be coupled to a device under test (DUT); an optical to electrical converter configured to generate a first electrical current based on the optical spectrum without the optical spectrum passing through the DUT; and generate a second electrical current based on the optical spectrum after the optical spectrum passes through the DUT; and a data processor coupled to the optical to electrical converter, the data processor being configured to determine a transfer function of the DUT at an average of the two different nominal carrier frequencies based on the first electrical current and the second electrical current.

Abstract: An apparatus comprises a phase modulator having a first input port to receive a radiation and having a first output port to provide a first signal toward a device under test (DUT), wherein the phase modulator is configured to generate the first signal by performing phase modulation on the radiation received at the first input port; an intensity modulator having a second input port to receive the radiation and having a second output port to provide a second signal toward the DUT, wherein the intensity modulator is configured to generate the second signal by performing intensity modulation on the radiation received at the second input port; and a transfer function analyzer configured to determine a transfer function of the DUT based on the first signal and the second signal.

Abstract: An apparatus comprises a phase modulator having a first input port to receive a radiation and having a first output port to provide a first signal toward a device under test (DUT), wherein the phase modulator is configured to generate the first signal by performing phase modulation on the radiation received at the first input port; an intensity modulator having a second input port to receive the radiation and having a second output port to provide a second signal toward the DUT, wherein the intensity modulator is configured to generate the second signal by performing intensity modulation on the radiation received at the second input port; and a transfer function analyzer configured to determine a transfer function of the DUT based on the first signal and the second signal.

Abstract: A submicron structure having a silica body defining a plurality of pores is described. The submicron body may be spherical or non-spherical, and may include a cationic polymer or co-polymer on the surface of said silica body. The submicron structure may further include an oligonucleotide and be used to deliver the oligonucleotide to a cell. The submicron structure may further include a therapeutic agent and be used to deliver the therapeutic agent to a cell. An oligonucleotide and therapeutic agent may be used together. For example, when the oligonucleotide is an siRNA, the composition may be used to decrease cellular resistance to the therapeutic agent by decreasing translation of a resistance gene.

Abstract: A method includes retrieving de-identified records for individuals from at least two different databases. Each of the databases stores a different type of information for the individuals. The method further includes identifying a set of features common across the at least two different databases. The method further includes generating a unique identification for each of the individuals in the retrieved de-identified records based on the set of features. The method further includes computing a rarity coefficient for each of the individuals based on the set of features. The method further includes matching the de-identified entities across the at least two different databases based on the rarity coefficients. The method further includes matching the de-identified patient records for a set of matched de-identified entities. The method further includes constructing a database with one or more sets of the matched de-identified records.

Abstract: The present disclosure relates to an authentication method and an authentication device for a wireless router. The authentication method may first generate a corresponding 2-dimensional barcode with BSSID and PIN codes of the wireless router. The authentication method may scan the 2-dimensional barcode and may resolve the scanned 2-dimensional barcode to corresponding BSSID and PIN codes. The authentication method may correlate the corresponding wireless router according to the BSSID, may activate a WPS process of the wireless router, and may access a network provided by the wireless router via the PIN code. Thereby, a user can access a wireless router and may go online by using a mobile terminal to scan a 2-dimensional barcode. As a result, the mobile terminal can be conveniently and quickly connected to a wireless router, which may greatly reduce the user's operations and results in great convenience for users.

Abstract: Methods and compositions for quantifying the cellular concentration of cyclic adenosine monophosphate (cAMP), cyclic guanine monophosphate (cGMP), glutathione, glucose, and glutamine in a single cell include the use of conjugates and analogs in immunofluorescent assays for on-chip quantification. These metabolite immunofluorescent assays may be incorporated with proteomic assays for simultaneous single cell analysis of metabolites and proteins.

Abstract: The present disclosure relates to an authentication method and an authentication device for a wireless router. The authentication method may first generate a corresponding 2-dimensional barcode with BSSID and PIN codes of the wireless router. The authentication method may scan the 2-dimensional barcode and may resolve the scanned 2-dimensional barcode to corresponding BSSID and PIN codes. The authentication method may correlate the corresponding wireless router according to the BSSID, may activate a WPS process of the wireless router, and may access a network provided by the wireless router via the PIN code. Thereby, a user can access a wireless router and may go online by using a mobile terminal to scan a 2-dimensional barcode. As a result, the mobile terminal can be conveniently and quickly connected to a wireless router, which may greatly reduce the user's operations and results in great convenience for users.

Abstract: A body coil assembly for a magnetic resonance apparatus has a first coil and a second coil for generating a radio-frequency field in space, and a power control apparatus connected to the first coil and the second coil for controlling the transmitting power of the first coil and the second coil. In a method for generating a radio-frequency field using such a body coil assembly, the transmitting powers of the first coil and the second coil are controlled, to provide unequal transmitting powers to the first coil and the second coil when needed to generate a required radio-frequency field distribution, so as to form a stronger field strength at a certain position, thus improving the signal to noise ratio at that position during the receiving process.

Abstract: A submicron structure having a silica body defining a plurality of pores is described. The submicron body may be spherical or non-spherical, and may include a cationic polymer or co-polymer on the surface of said silica body. The submicron structure may further include an oligonucleotide and be used to deliver the oligonucleotide to a cell. The submicron structure may further include a therapeutic agent and be used to deliver the therapeutic agent to a cell. An oligonucleotide and therapeutic agent may be used together. For example, when the oligonucleotide is an siRNA, the composition may be used to decrease cellular resistance to the therapeutic agent by decreasing translation of a resistance gene.

Abstract: A body coil assembly for a magnetic resonance apparatus has a first coil and a second coil for generating a radio-frequency field in space, and a power control apparatus connected to the first coil and the second coil for controlling the transmitting power of the first coil and the second coil. In a method for generating a radio-frequency field using such a body coil assembly, the transmitting powers of the first coil and the second coil are controlled, to provide unequal transmitting powers to the first coil and the second coil when needed to generate a required radio-frequency field distribution, so as to form a stronger field strength at a certain position, thus improving the signal to noise ratio at that position during the receiving process.