Abstract: A display substrate has a display area and an encapsulation area around the display area. The display substrate includes a substrate and a spacer layer. The spacer layer is located on a side of the substrate, and includes a plurality of first columnar spacers located in the encapsulation area and distributed at intervals around the display area, and bottom ends of the plurality of first columnar spacers are fixedly disposed on the substrate. Ends of the plurality of first columnar spacers proximate to the substrate are the bottom ends thereof, and ends of the plurality of first columnar spacers away from the substrate are top ends thereof.

Abstract: The present disclosure provides novel tetrahydropyran (THP)-substituted bicyclic pyrimidinedione compounds that are useful for the treatment of hypertrophic cardiomyopathy (HCM), conditions associated with left ventricular hypertrophy, conditions associated with diastolic dysfunction, and/or symptoms associated thereof. The synthesis and characterization of the compounds is described, as well as methods for treating HCM and other forms of heart disease.

Abstract: The present invention provides novel polymorphs of (R)-4-(1-((3-(difluoromethyl)-1-methyl-1H-pyrazol-4-yl)sulfonyl)-1-fluoroethyl)-N-(isoxazol-3-yl)piperidine-1-carboxamide (I-491) that are useful for the treatment of cardiac disorders including systolic dysfunction, dilated cardiomyopathy (DCM), heart failure with reserved ejection fraction (HFrEF), and conditions associated with left and/or right ventricular systolic dysfunction or systolic reserve. The synthesis and characterization of the polymorphs is described, as well as methods for treating systolic dysfunction, DCM, HFrEF, and other forms of heart disease.

Abstract: An air handling assembly and a cleaning apparatus having same are provided. The air handling assembly includes: a cyclonic chamber, a cyclonic cone, a dust collection chamber and an exhaust chamber. The cyclonic chamber has a dirty air inlet, a clean air outlet and a dust fall opening. The cyclonic cone is arranged inside the cyclonic chamber, an air exit of the cyclonic cone is arranged away from the dust fall opening, and an end of the cyclonic cone close to the dust fall opening is spaced apart from an end of the cyclonic chamber at which the dust fall opening is arranged.

Abstract: An ultrasonic imaging method and an ultrasonic imaging system are provided herein. The ultrasonic imaging system includes: a scanning assembly having an ultrasonic transducer to send ultrasonic signals to a tissue to be scanned and acquire a plurality of ultrasonic echo signals at a plurality of positions; a processor to receive the plurality of ultrasonic echo signals acquired at the plurality of positions, and generate an ultrasonic image corresponding to each of the plurality of positions; a display to display the ultrasonic images; and a user input unit to select the ultrasonic image corresponding to any specific position and send an input signal that is configured to control movement of the ultrasonic transducer, driven by a driving device, to the specific position. Also provided in the present invention is an ultrasonic imaging method using the system.

Abstract: The present invention provides novel 4-methylsulphone-substituted piperidine urea compounds that are useful for the treatment of dilated cardiomyopathy (DCM) and conditions associated with left and/or right ventricular systolic dysfunction or systolic reserve. The synthesis and characterization of the compounds is described, as well as methods for treating DCM and other forms of heart disease.

Abstract: The present disclosure provides novel tetrahydropyran (THP)-substituted bicyclic pyrimidinedione compounds that are useful for the treatment of hypertrophic cardiomyopathy (HCM), conditions associated with left ventricular hypertrophy, conditions associated with diastolic dysfunction, and/or symptoms associated thereof. The synthesis and characterization of the compounds is described, as well as methods for treating HCM and other forms of heart disease.

Abstract: The present disclosure discloses a quickly dismantlable floor member and a spliced floor, to solve the technical problem that the conventional floor members cannot be dismantled conveniently for repairing and replacement. The quickly dismantlable floor member is of a tetragon shape, a lateral face of a first side of the quickly dismantlable floor member is provided with an automatic latch, the automatic latch comprises a locking head, the locking head is retractable, and the locking head is able to, after the quickly dismantlable floor member is installed, join with an neighboring conventional floor member. The spliced floor employs three or more quickly dismantlable floor members.

Abstract: A transition metal dichalcogenide transistor, comprising: a gate, a gate dielectric layer and a channel layer from bottom to top, a source/drain region are located on both the sides of the gate dielectric layer, wherein, in a plane paralleled to the channel layer, the length of the channel layer in each direction is greater than the length of the gate dielectric layer, and the length of the gate dielectric layer in each direction is greater than or equal to the length of the gate; wherein, the source/drain region are a first transition metal dichalcogenide with metallic properties, and the channel layer is a second transition metal dichalcogenide with semiconductor properties.

Abstract: The present invention provides novel 4-methylsulphone-substituted piperidine urea compounds that are useful for the treatment of dilated cardiomyopathy (DCM) and conditions associated with left and/or right ventricular systolic dysfunction or systolic reserve. The synthesis and characterization of the compounds is described, as well as methods for treating DCM and other forms of heart disease.

Abstract: The present disclosure provides novel 5,6,7,8-tetrahydropyrido[2,3-d]pyrimidine-2,4-diones of formula (I): The compounds of formula (I) are useful for the treatment of hypertrophic cardiomyopathy (HCM), conditions associated with left ventricular hypertrophy, conditions associated with diastolic dysfunction, and/or symptoms associated thereof. The synthesis and characterization of the compounds is described, as well as methods for treating HCM and other forms of heart disease.

Abstract: The present invention provides compounds having formula (I): and pharmaceutically acceptable derivatives thereof, wherein R1-R4, n, p, A, B, D, E, L and AR1 are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of disorders mediated by the CD11/CD18 family of cellular adhesion molecules (e.g., LFA-1).

Abstract: The present invention provides novel polymorphs of (R)-4-(1-(3-(difluoromethyl)-1-methyl-1H-pyrazol-4-yl)sulfonyl)-1-fluoroethyl)-N-(isoxazol-3-yl)piperidine-1-carboxamide (I-491) that are useful for the treatment of cardiac disorders including systolic dysfunction, dilated cardiomyopathy (DCM), heart failure with reserved ejection fraction (HFrEF), and conditions associated with left and/or right ventricular systolic dysfunction or systolic reserve. The synthesis and characterization of the polymorphs is described, as well as methods for treating systolic dysfunction, DCM, HFrEF, and other forms of heart disease.

Abstract: The present invention provides compounds useful as inhibitors of Btk, compositions thereof, and methods of using the same.

Abstract: The present invention provides novel 4-methylsulphone-substituted piperidine urea compounds that are useful for the treatment of dilated cardiomyopathy (DCM) and conditions associated with left and/or right ventricular systolic dysfunction or systolic reserve. The synthesis and characterization of the compounds is described, as well as methods for treating DCM and other forms of heart disease.

Abstract: A method and a device for driving a display panel, and a display device are provided. The method includes: dividing the display panel into at least two display regions, where each display region corresponds to a timing controller, and the timing controller is configured to control the corresponding display region to display; dividing each display region into multiple detection blocks; detecting whether a defect block exists in each display region; and enabling, when the defect block exists in only one display region, by the timing controller corresponding to the only one display region, a pattern detection function, and enabling, when the defect block exists in each of more than one display region, by the timing controllers corresponding to the more than one display region simultaneously, the pattern detection function.

Abstract: The present disclosure discloses a quickly dismantlable floor member and a spliced floor, to solve the technical problem that the conventional floor members cannot be dismantled conveniently for repairing and replacement. The quickly dismantlable floor member is of a tetragon shape, a lateral face of a first side of the quickly dismantlable floor member is provided with an automatic latch, the automatic latch comprises a locking head, the locking head is retractable, and the locking head is able to, after the quickly dismantlable floor member is installed, join with an neighboring conventional floor member. The spliced floor employs three or more quickly dismantlable floor members.

Abstract: The present invention provides novel 4-methylsulphone-substituted piperidine urea compounds that are useful for the treatment of dilated cardiomyopathy (DCM) and conditions associated with left and/or right ventricular systolic dysfunction or systolic reserve. The synthesis and characterization of the compounds is described, as well as methods for treating DCM and other forms of heart disease.

Abstract: A method and a device for driving a display panel, and a display device are provided. The method includes: dividing the display panel into at least two display regions, where each display region corresponds to a timing controller, and the timing controller is configured to control the corresponding display region to display; dividing each display region into multiple detection blocks; detecting whether a defect block exists in each display region; and enabling, when the defect block exists in only one display region, by the timing controller corresponding to the only one display region, a pattern detection function, and enabling, when the defect block exists in each of more than one display region, by the timing controllers corresponding to the more than one display region simultaneously, the pattern detection function.

Abstract: The present disclosure provides novel tetrahydropyran (THP)-substituted bicyclic pyrimidinedione compounds that are useful for the treatment of hypertrophic cardiomyopathy (HCM), conditions associated with left ventricular hypertrophy, conditions associated with diastolic dysfunction, and/or symptoms associated thereof. The synthesis and characterization of the compounds is described, as well as methods for treating HCM and other forms of heart disease.