Abstract: An ion exchange column and a method of using the same are disclosed. The ion exchange column includes first interconnected chambers supporting a first portion of an ion exchange resin, second interconnected chambers supporting a second portion of the ion exchange resin, and a housing or casing enclosing the first and second interconnected chambers and the first and second ion exchange resin portions. The second chambers are physically isolated and/or separated from the first chambers. The ion exchange column is configured to cause a fluid passing through the first or second interconnected chambers to travel along a path that is longer than a height of the interconnected chambers. The present column and method improve efficiencies of fluid treatment and resin regeneration relative to a conventional dual-column design, and increase residence time between the resin and the fluid or regenerant relative to an otherwise identical single-column design.