Patents by Inventor Mina J. Bissell

Mina J. Bissell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of increasing radiation sensitivity by inhibition of beta one integrin
    Patent number: 7618627
    Abstract: A method for increasing or monitoring apoptosis in tumor cells by the co-administration of ionizing radiation and an anti-integrin antibody. Increasing apoptosis reduces tumor growth in vivo and in a cell culture model. The antibody is directed against the beta-1 integrin subunit and is inhibitory of beta-1 integrin signaling. Other molecules having an inhibitory effect on beta-1 integrin, either in signaling or in binding to its cognate extracellular receptors may also be used. The present method is particularly of interest in treatment of tumor cells associated with breast cancer, wherein radiation is currently used alone. The present method further contemplates a monoclonal antibody suitable for human administration that may further comprise a radioisotope attached thereto.
    Type: Grant
    Filed: June 2, 2005
    Date of Patent: November 17, 2009
    Assignee: The Regents of the University of California
    Inventors: Catherine Park, Mina J. Bissell
  • TARGETING TNF-alpha CONVERTING ENZYME(TACE)- DEPENDENT GROWTH FACTOR SHEDDING IN CANCER THERAPY
    Publication number: 20090274626
    Abstract: The invention provides methods for modulating tumor cell proliferation by contacting cells (e.g. tumor cells) with a TACE inhibitor and a compound that inhibits EGFR tyrosine kinase, whereby the TACE inhibitor enhances the sensitivity of the cell to the EGFR tyrosine kinase inhibitor. Additionally, methods for treating cancer and methods for identifying TACE inhibitors is also provided.
    Type: Application
    Filed: January 29, 2008
    Publication date: November 5, 2009
    Applicant: The Regents of the University of California
    Inventors: Paraic A. Kenny, Mina J. Bissell
  • IDENTIFICATION OF RAC1B AS A MARKER AND MEDIATOR OF METALLOPROTEINASE-INDUCED MALIGNANCY
    Publication number: 20090191543
    Abstract: The present invention provides compositions and methods for detecting MMP-induced malignancies by detecting Rac1b expression. The invention further provides compositions and in vitro and in vivo methods for inhibiting MMP-induced malignant transformation by modulating Rac1b expression and/or function.
    Type: Application
    Filed: May 26, 2006
    Publication date: July 30, 2009
    Applicant: THEREGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Derek C. Radisky, Celeste M. Nelson, Mina J. Bissell
  • Design of novel assays based on the newly found role of dystroglycan and alpha-dystroglycan proteolysis in tumor cell growth
    Patent number: 6982151
    Abstract: The invention provides method for assessing tumorigenicity of mammalian cells by assaying the proteolytic fragments of 120-130 kD alpha-dystroglycan in medium surrounding mammalian cells.
    Type: Grant
    Filed: August 31, 2000
    Date of Patent: January 3, 2006
    Assignee: The Regents of the University of California
    Inventors: Mina J. Bissell, John L. Muschler
  • Method for restoration of normal phenotype in cancer cells
    Patent number: 6123941
    Abstract: A method for reversing expression of malignant phenotype in cancer cells is described. The method comprises applying .beta..sub.1 integrin function-blocking antibody to the cells. The method can be used to assess the progress of cancer therapy. Human breast epithelial cells were shown to be particularly responsive.
    Type: Grant
    Filed: April 28, 1998
    Date of Patent: September 26, 2000
    Assignee: The Regents of the University of California
    Inventors: Mina J. Bissell, Valerie M. Weaver
  • Transcriptional enhancer from milk protein genes
    Patent number: 6004805
    Abstract: The invention relates to novel enhancer nucleotide sequences which stimulate transcription of heterologous DNA in cells in culture. The enhancers are derived from major milk protein genes by the process of deletion mapping and functional analysis. The invention also relates to expression vectors containing the novel enhancers.
    Type: Grant
    Filed: May 29, 1992
    Date of Patent: December 21, 1999
    Assignee: G.D Searle & Co.
    Inventors: Gerald F. Casperson, Christian T. Schmidhauser, Mina J. Bissell
  • Restoration of normal phenotype in cancer cells
    Patent number: 5846536
    Abstract: A method for reversing expression of malignant phenotype in cancer cells is described. The method comprises applying .beta..sub.1 integrin function-blocking antibody to the cells. The method can be used to assess the progress of cancer therapy. Human breast epithelial cells were shown to be particularly responsive.
    Type: Grant
    Filed: October 4, 1996
    Date of Patent: December 8, 1998
    Assignee: The Regents of the University of California
    Inventors: Mina J. Bissell, Valerie M. Weaver