Abstract: The present disclosure relates to anti-microbial film, and more particularly to anti-microbial film for packaging of a perishable item. According to an aspect, the present disclosure is directed to a packaging film comprising a polymer film having a surface, and an antimicrobial agent chemically linked to the surface. According to an aspect, the present disclosure is directed to a method of preparing a packaging film, the method comprising: (a) providing a polymer film having a surface; (b) modifying the surface by UV, plasma or corona treatment; and (c) chemically linking an antimicrobial agent to the modified surface. In an embodiment, the packaging film may be used in packaging for a perishable item.

Abstract: An internal fixator apparatus comprises a barrel member having a bone interface adapted to be anchored to a first part of a bone in an extramedullary connection. A piston member has a bone interface adapted to be anchored to a first part of a bone, the piston member including a threaded nut portion, the barrel member and the piston member being operatively connected to concurrently form a joint whereby the barrel member and the piston member are displaceable at least in translation relative to one another. A fixator mechanism is inside the barrel member and the piston member, the fixator mechanism comprising at least a leadscrew threadingly engaged with the threaded nut portion, and at least one magnet connected to the leadscrew to rotate concurrently therewith, the magnet being rotatingly received in the barrel member.

Abstract: It is provided a chitosan sponge for bone regeneration in a subject, comprising chitosan; a purine compound such as guanosine 5?-diphosphate (GDP); and at least one of a growth factor and a pyrophosphatase. Preferably the growth factor is BMP-7. The sponge is formed when the chitosan and the growth factor and/or pyrophosphatase is mixed with the purine compound such as guanosine 5?-diphosphate.

Abstract: It is disclosed Guanosine 5?-Diphosphate (GDP) crosslinked chitosan sponge or gelling composition which is used as a scaffold for tissue regeneration applications such as neural, cardiac, cartilage and bone regeneration. In addition, the sponge acts as a drug delivery system to provide local controlled drug release, such as delivering anti-cancer drugs locally at the tumor site.

Abstract: It is disclosed Guanosine 5?-Diphosphate (GDP) crosslinked chitosan sponge or gelling composition which is used as a scaffold for tissue regeneration applications such as neural, cardiac, cartilage and bone regeneration. In addition, the sponge acts as a drug delivery system to provide local controlled drug release, such as delivering anti-cancer drugs locally at the tumor site.

Abstract: Novel compositions comprising genipin for cross-linking polymer fibers, are provided. In aspects of the invention the compositions further comprise a solvent system, wherein said solvent system comprises alcohol solvent and water. The genipin-based compositions are useful in methods for promoting the stabilization of fibers in an aqueous environment, and in tissue engineering. The novel genipin-based composition is also useful in methods of treating dermatological conditions.