Patents by Inventor Minako Hoshi

Minako Hoshi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230021187
    Abstract: A substance that can be a substitute for amylospheroids (ASPD) and a method for analyzing ASPD are provided. Viewed from one aspect, the present disclosure relates to a substance in which amyloid-? protein (A?) is cross-linked with a cross-linking agent that has a spacer arm length of between 4 ? and 50 ? inclusive or a cross-linking agent that has, as a spacer arm, not less than 1 and not more than 13 groups that are an oxyethylene group(s) (—CH2CH2O—) and/or an oxypropylene group(s) (—CH2CH2CH3O—). Viewed from another aspect, the present disclosure relates to a method for analyzing ASPD using the substance as a reference material.
    Type: Application
    Filed: November 18, 2020
    Publication date: January 19, 2023
    Applicant: FOUNDATION FOR BIOMEDICAL RESEARCH AND INNOVATION AT KOBE
    Inventors: Minako HOSHI, Yoshie ARAI, Kiyotaka MACHIDA
  • Publication number: 20210214406
    Abstract: Provided are a cell secreted-type amylospheroids-like structure, a drug and vaccine using the same, as well as a method of producing the same. In one aspect, the present disclosure relates to a production method including a step of culturing, in a culture medium, cells that express an amyloid precursor protein (APP) or a part thereof containing an amyloid beta-protein (Aß) sequence to obtain a cell secreted-type amylospheroids (ASPD)-like structure in said culture medium.
    Type: Application
    Filed: April 13, 2017
    Publication date: July 15, 2021
    Applicant: TAO HEALTH LIFE PHARMA CO., LTD.
    Inventors: Minako HOSHI, Yoshie ARAI
  • Publication number: 20190145962
    Abstract: Provided is a peptide having an ability to inhibit binding between amylospheroids (ASPD) and neurons. In one aspect, provided is a synthesized, isolated, or purified polypeptide represented by Formula (I) or (II) below: X1X2X3X4 (I), where X1 is R, H, or K, X2 is R, K, D, H, W, Q, Y, or T, X3 is any amino acid, and X4 is W, F, or Y; and X1X2X3X4 (II), where X1 is R, H, or K, X2 is any amino acid, X3 is L, G, I, W, R, M, D, E, A, V, or K, and X4 is W, F, or Y.
    Type: Application
    Filed: April 13, 2017
    Publication date: May 16, 2019
    Applicant: TAO HEALTH LIFE PHARMA CO., LTD.
    Inventors: Minako HOSHI, Tomoya SASAHARA, Eri SAIJYO, Genji IWASAKI, Ichiro MORI
  • Publication number: 20170327536
    Abstract: In one or a plurality of embodiments, there is provided a target molecule of amylospheroid, which is expressed in mature neurons and to which the amylospheroid binds to induce death of cells. Further, in one or a plurality of embodiments, there is provided a method and a substance for inhibiting death of mature neurons induced by the amylospheroid. In one aspect, the present disclosure relates to a use of Na?/K+?ATPase ?3 as a binding target molecule of amylospheroid. In another aspect, the present disclosure relates to a method for suppressing death of mature neurons induced by the amylospheroid, including inhibiting protein-protein interaction between the amylospheroid and the Na+/K+?ATPase ?3, and the like.
    Type: Application
    Filed: July 27, 2017
    Publication date: November 16, 2017
    Inventor: Minako HOSHI
  • Patent number: 9751912
    Abstract: In one or a plurality of embodiments, there is provided a target molecule of amylospheroid, which is expressed in mature neurons and to which the amylospheroid binds to induce death of cells. Further, in one or a plurality of embodiments, there is provided a method and a substance for inhibiting death of mature neurons induced by the amylospheroid. In one aspect, the present disclosure relates to a use of Na+/K+-ATPase ?3 as a binding target molecule of amylospheroid. In another aspect, the present disclosure relates to a method for suppressing death of mature neurons induced by the amylospheroid, including inhibiting protein-protein interaction between the amylospheroid and the Na+/K+-ATPase ?3, and the like.
    Type: Grant
    Filed: December 28, 2012
    Date of Patent: September 5, 2017
    Assignee: TAO HEALTH LIFE PHARMA CO., LTD.
    Inventor: Minako Hoshi
  • Patent number: 8946327
    Abstract: Provided is a method for producing synthetic amylospheroids efficiently, the method including agitating a liquid containing amyloid ?-peptides in the presence of a plasticizer. Amylospheroid refers to an assembly of amyloid ?-peptides that selectively can induce cell death of functionally mature neurons. Amylospheroid is considered to play a central role in the development of Alzheimer's disease and dementia with Lewy bodies.
    Type: Grant
    Filed: December 18, 2012
    Date of Patent: February 3, 2015
    Assignee: Tao Health Life Pharma Co., Ltd.
    Inventor: Minako Hoshi
  • Publication number: 20140350229
    Abstract: Provided is a method for producing synthetic amylospheroids efficiently, the method including agitating a liquid containing amyloid ?-peptides in the presence of a plasticizer. Amylospheroid refers to an assembly of amyloid ?-peptides that selectively can induce cell death of functionally mature neurons. Amylospheroid is considered to play a central role in the development of Alzheimer's disease and dementia with Lewy bodies.
    Type: Application
    Filed: December 18, 2012
    Publication date: November 27, 2014
    Inventor: Minako Hoshi
  • Patent number: 8445649
    Abstract: An antibody provided by the present invention has a low reactivity with amyloid precursor proteins, and has a higher reactivity with amylospheroids than with amyloid ? fibrils or monomeric amyloid ?-proteins. According to the present invention, an antibody is provided that has a higher reactivity with amylospheroids than with amyloid precursor proteins, and has any one or more of the following properties: (i) a higher activity with amylospheroids than with amyloid ? fibrils; (ii) a higher reactivity with amylospheroids than with monomeric amyloid ?-proteins; and (iii) an activity of inhibiting neuronal cell death induced by amylospheroids.
    Type: Grant
    Filed: October 29, 2008
    Date of Patent: May 21, 2013
    Assignee: Tao Health Life Pharma Co., Ltd.
    Inventors: Minako Hoshi, Michio Sato, Shoji Ideno, Koji Naito, Satoshi Horie, Munehiro Noda, Hajime Horii
  • Patent number: 8168188
    Abstract: The present invention is directed to providing an antibody having greater reactivity with amylospheroid than with amyloid ? fibers, and the like. The aforementioned antibody includes an antibody having activity of inhibiting amylospheroid formation or activity of inhibiting neuronal cell death induced by amylospheroid. The antibody can be used for a therapeutic and/or preventive agent for Alzheimer's disease, or a screening thereof, a method and reagent for detecting individuals with Alzheimer's disease, and the like.
    Type: Grant
    Filed: August 11, 2005
    Date of Patent: May 1, 2012
    Assignee: Kyoto University
    Inventors: Minako Hoshi, Koji Naito, Shouji Ideno
  • Publication number: 20100297662
    Abstract: An antibody provided by the present invention has a low reactivity with amyloid precursor proteins, and has a higher reactivity with amylospheroids than with amyloid ? fibrils or monomeric amyloid ?-proteins. According to the present invention, an antibody is provided that has a higher reactivity with amylospheroids than with amyloid precursor proteins, and has any one or more of the following properties: (i) a higher activity with amylospheroids than with amyloid ? fibrils; (ii) a higher reactivity with amylospheroids than with monomeric amyloid ?-proteins; and (iii) an activity of inhibiting neuronal cell death induced by amylospheroids.
    Type: Application
    Filed: October 29, 2008
    Publication date: November 25, 2010
    Inventors: Minako Hoshi, Michio Sato, Shoji Ideno, Koji Naito, Satoshi Horie, Munehiro Noda, Hajime Horii