Patent number: 6337399
Abstract: This invention relates to processes for producing a 7-isoindoline-quinolonecarboxylic acid derivative represented by the general formula [1] which is useful as an antibacterial agent, and an intermediate thereof:
wherein R1 represents a hydrogen atom or a carboxyl-protecting group; R2 represents a substituted or unsubstituted alkyl, alkenyl, cycloalkyl, aryl or heterocyclic group; R3 represents at least one group selected from hydrogen atom, halogen atoms, substituted or unsubstituted alkyl, alkenyl, cycloalkyl, aryl, alkoxy or alkylthio groups, nitro group, cyano group, acyl groups, protected or unprotected hydroxyl groups and protected or unprotected or substituted or unsubstituted amino groups; R4 represents at least one group selected from hydrogen atom, halogen atoms, substituted or unsubstituted alkyl, alkenyl, cycloalkyl, aralkyl, aryl, alkoxy or alkylthio groups, protected or unprotected hydroxyl or imino groups, protected or unprotected or substituted or unsubstituted amin
Type:
Grant
Filed:
April 26, 2000
Date of Patent:
January 8, 2002
Assignee:
Toyama Chemical Co., Ltd.
Inventors:
Minoru Yamada, Shoichi Hamamoto, Kazuya Hayashi, Kazuko Takaoka, Hiroko Matsukura, Minako Yotsuji, Kenji Yonezawa, Katsuji Ojima, Tamotsu Takamatsu, Kyoko Taya, Hirohiko Yamamoto, Taro Kiyoto, Hironori Kotsubo