Patents by Inventor Minako Yotsuji

Minako Yotsuji has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20070225506
    Abstract: Process for producing a 7-bromoquinolone-carboxylic acid derivative of the following formula or its salt by reacting a 2,4-dibromo-3-hydroxybenzoic acid ester compound of the formula R7a-x to obtain a 3-alkoxy-2,4-dibromobenzoic acid ester, subjecting the 3-alkoxy-2,4-dibromobenzoic acid ester to elimination reaction of the carboxyl-protecting group to obtain a 3-alkoxy-2,4-dibromobenzoic acid, subjecting the 3-alkoxy-2,4-dibromobenzoic acid to ketoesterification reaction to obtain a 3-alkoxy-2,4-dibromobenyolacetic acid ester, reacting the 3-alkoxy-2,4-dibromobenzoylacetic acid ester with an orthoester or an acetal, then reacting the reaction product with a compound of the formula R2— NH or its salt to obtain a 2-(3-alkoxy-2,4-dibromobenzoyl)-3-substituted aminoacrylic acid ester and subjecting the 2-(3-alkoxy-2,4-dibromobenzoyl)-3-substituted aminoacrylic acid ester to ring-closing reaction, and products thereof.
    Type: Application
    Filed: March 27, 2007
    Publication date: September 27, 2007
    Applicant: Toyama Chemical Co., Ltd.
    Inventors: Minoru Yamada, Shoichi Hamamoto, Kazuya Hayashi, Kazuko Takaoka, Hiroko Matsukura, Minako Yotsuji, Kenji Yonezawa, Katsuji Ojima, Tamotsu Takamatsu, Kyoko Taya, Hirohiko Yamamoto, Taro Kiyoto, Hironori Kotsubo
  • Patent number: 6482835
    Abstract: Processes for producing a 7-isoindoline-quinolonecarboxylic acid derivative represented by the general formula [1] which is useful as an antibacterial agent, and an intermediate thereof: comprising reacting, in the presence of metallic palladium, an isoindoline-5-boronic acid, or of a 5-halogenoisoindoline, in the presence of a palladium catalyst, with a dialkoxyborane or an alkoxydiborane.
    Type: Grant
    Filed: September 25, 2001
    Date of Patent: November 19, 2002
    Assignee: Toyama Chemical Co., Ltd.
    Inventors: Minoru Yamada, Shoichi Hamamoto, Kazuya Hayashi, Kazuko Takaoka, Hiroko Matsukura, Minako Yotsuji, Kenji Yonezawa, Katsuji Ojima, Tamotsu Takamatsu, Kyoko Taya, Hirohiko Yamamoto, Taro Kiyoto, Hironori Kotsubo
  • Publication number: 20020049328
    Abstract: Processes for producing a 7-isoindoline-quinolonecarboxylic acid derivative represented by the general formula [1] which is useful as an antibacterial agent, and an intermediate thereof: 1
    Type: Application
    Filed: September 25, 2001
    Publication date: April 25, 2002
    Applicant: TOYAMA CHEMICAL CO., LTD.
    Inventors: Minoru Yamada, Shoichi Hamamoto, Kazuya Hayashi, Kazuko Takaoka, Hiroko Matsukura, Minako Yotsuji, Kenji Yonezawa, Katsuji Ojima, Tamotsu Takamatsu, Kyoko Taya, Hirohiko Yamamoto, Taro Kiyoto, Hironori Kotsubo
  • Patent number: 6337399
    Abstract: This invention relates to processes for producing a 7-isoindoline-quinolonecarboxylic acid derivative represented by the general formula [1] which is useful as an antibacterial agent, and an intermediate thereof: wherein R1 represents a hydrogen atom or a carboxyl-protecting group; R2 represents a substituted or unsubstituted alkyl, alkenyl, cycloalkyl, aryl or heterocyclic group; R3 represents at least one group selected from hydrogen atom, halogen atoms, substituted or unsubstituted alkyl, alkenyl, cycloalkyl, aryl, alkoxy or alkylthio groups, nitro group, cyano group, acyl groups, protected or unprotected hydroxyl groups and protected or unprotected or substituted or unsubstituted amino groups; R4 represents at least one group selected from hydrogen atom, halogen atoms, substituted or unsubstituted alkyl, alkenyl, cycloalkyl, aralkyl, aryl, alkoxy or alkylthio groups, protected or unprotected hydroxyl or imino groups, protected or unprotected or substituted or unsubstituted amin
    Type: Grant
    Filed: April 26, 2000
    Date of Patent: January 8, 2002
    Assignee: Toyama Chemical Co., Ltd.
    Inventors: Minoru Yamada, Shoichi Hamamoto, Kazuya Hayashi, Kazuko Takaoka, Hiroko Matsukura, Minako Yotsuji, Kenji Yonezawa, Katsuji Ojima, Tamotsu Takamatsu, Kyoko Taya, Hirohiko Yamamoto, Taro Kiyoto, Hironori Kotsubo
  • Patent number: 5605921
    Abstract: The present invention relates to a compound represented by the general formula (1) or its salt, a process for producing the same, and an antifungal agent comprising the same as an effective component: ##STR1## wherein R.sup.1 represents a substituted or unsubstituted aryl group or a substituted or unsubstituted heterocyclic group bonded through a carbon atom in the ring to the main chain; R.sup.2 presents a hydrogen atom, a fluorine atom or a substituted or unsubstituted alkyl group; and R.sup.3 represents a cyano group, a thioamido group or a group represented by the formula ##STR2## in which R.sup.4 is a hydroxyl group or a group of the formula ##STR3## (R.sup.7 and R.sup.8, which may be the same or different, are hydrogen atoms or substituted or unsubstituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, amino, alkoxy, hydroxyl or heterocyclic groups, and may form a substituted or unsubstituted heterocyclic group together with the nitrogen atom to which R.sup.7 and R.sup.8 attach), R.sup.
    Type: Grant
    Filed: June 17, 1994
    Date of Patent: February 25, 1997
    Assignee: Toyama Chemical Co., Ltd.
    Inventors: Hiroyuki Imaizumi, Tetsuya Kajita, Kenichi Takashima, Minako Yotsuji, Keiko Takakura, Akira Yotsuji, Junichi Mitsuyama, Katsumi Shimizu, Hiroshi Sakai, Hirokazu Narita
  • Patent number: 5366989
    Abstract: The present invention relates to a compound represented by the general formula (1) or its salt, a process for producing the same, and an antifungal agent comprising the same as an effective component: ##STR1## wherein R.sup.1 represents a substituted or unsubstituted aryl group or a substituted or unsubstituted heterocyclic group bonded through a carbon atom in the ring to the main chain; R.sup.2 presents a hydrogen atom, a fluorine atom or a substituted or unsubstituted alkyl group; and R.sup.3 represents a cyano group, a thioamido group or a group represented by the formula ##STR2## in which R.sup.4 is a hydroxyl group or a group of the formula ##STR3## (R.sup.7 and R.sup.8, which may be the same or different, are hydrogen atoms or substituted or unsubstituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, amino, alkoxy, hydroxyl or heterocyclic groups, and may form a substituted or unsubstituted heterocyclic group together with the nitrogen atom to which R.sup.7 and R.sup.8 attach), R.sup.
    Type: Grant
    Filed: December 8, 1992
    Date of Patent: November 22, 1994
    Assignee: Toyama Chemical Co., Ltd.
    Inventors: Hiroyuki Imaizumi, Tetsuya Kajita, Kenichi Takashima, Minako Yotsuji, Keiko Takakura, Akira Yotsuji, Junichi Mitsuyama, Katsumi Shimizu, Hiroshi Sakai, Hirokazu Narita
  • Patent number: 5120746
    Abstract: This invention relates to amine derivatives and salts thereof. These compounds have an anti-ulcer activity which is effective to human beings and animals. This disclosure relates to such compound, a process for the preparation thereof and an anti-ulcer agent containing the same.
    Type: Grant
    Filed: March 30, 1990
    Date of Patent: June 9, 1992
    Assignee: Toyama Chemical Co., Ltd.
    Inventors: Shiro Hirai, Hiroshi Hirano, Hirotoshi Arai, Yasuo Kiba, Hisanari Shibata, Yoshikazu Kusayanag, Minako Yotsuji, Kazuhiko Hashiba, Kikuko Tanada
  • Patent number: 4923882
    Abstract: This invention relates to amine derivatives and salts thereof. These compounds have an anti-ulcer activity which is effective to human beings and animals. This disclosure relates to such compound, a process for the preparation thereof and an anti-ulcer agent containing the same.
    Type: Grant
    Filed: October 16, 1986
    Date of Patent: May 8, 1990
    Assignee: Toyama Chemical Co., Ltd.
    Inventors: Shiro Hirai, Hiroshi Hirano, Hirotoshi Arai, Yasuo Kiba, Hisanari Shibata, Yoshikazu Kusayanag, Minako Yotsuji, Kazuhiko Hashiba, Kikuko Tanada
  • Patent number: 4643849
    Abstract: This invention relates to amine derivatives and salts thereof. These compounds have an anti-ulcer activity which is effective to human beings and animals. This disclosure relates to such compounds, a process for the preparation thereof and an anti-ulcer agent containing the same.
    Type: Grant
    Filed: November 14, 1983
    Date of Patent: February 17, 1987
    Assignee: Toyama Chemical Co., Ltd.
    Inventors: Shiro Hirai, Hiroshi Hirano, Hirotoshi Arai, Yasuo Kiba, Hisanari Shibata, Yoshikazu Kusayanagi, Minako Yotsuji, Kazuhiko Hashiba, Kikuko Tanada
  • Patent number: 4472386
    Abstract: 5-Fluoro-(.beta.-uridine or 2'-deoxy-.beta.-uridine) derivatives having an acyl group at the 3-position of the molecule. These compounds are useful as carcinostatic agent. This disclosure relates to such compounds, a process for producing the same and a carcinostatic agent comprising such a compound.
    Type: Grant
    Filed: June 6, 1979
    Date of Patent: September 18, 1984
    Assignee: Toyama Chemical Co., Ltd.
    Inventors: Tsutomu Kodama, Masaakira Senoura, Hajime Aoyama, Tomonobu Yamaguchi, Isao Kitayama, Minako Yotsuji, Toru Hiraiwa, Masaharu Omori, Nobuo Terashima, Yutaka Kodama