Patents by Inventor Mindy Hsin-I Hsieh

Mindy Hsin-I Hsieh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CANCER PATIENT SELECTION FOR ADMINISTRATION OF WNT SIGNALING INHIBITORS USING RNF43 MUTATION STATUS
    Publication number: 20170306409
    Abstract: Disclosed are biomarkers, methods and assay for the identification of cancer patients who are predicted to benefit from the therapeutic administration of Wnt antagonist. The biomarkers include detection of RNF43 and ZNRF3 gene deletion, reduced RNF43 and ZNRF3 mRNA expression, reduced RNF43 and ZNRF3 protein expression, RNF43 and ZNRF3 inactivation mutation, phosphorylated LRP6, phophorylated Dishevelleds, and the expression of Frizzleds. These biomarkers can be associated with the better outcome for cancer patients treated with Wnt pathway inhibitors.
    Type: Application
    Filed: December 20, 2016
    Publication date: October 26, 2017
    Inventors: Feng CONG, Huaixiang HAO, Mindy Hsin-I HSIEH, Xiaomo JIANG, Jun LIU, Nicholas NG
  • CANCER PATIENT SELECTION FOR ADMINISTRATION OF Wnt SIGNALING INHIBITORS USING RNF43 MUTATION STATUS
    Publication number: 20150125857
    Abstract: Disclosed are biomarkers, methods and assay for the identification of cancer patients who are predicted to benefit from the therapeutic administration of Wnt antagonist. The biomarkers include detection of RNF43 and ZNRF3 gene deletion, reduced RNF43 and ZNRF3 mRNA expression, reduced RNF43 and ZNRF3 protein expression, RNF43 and ZNRF3 inactivation mutation, phosphorylated LRP6, phophorylated Dishevelleds, and the expression of Frizzleds. These biomarkers can be associated with the better outcome for cancer patients treated with Wnt pathway inhibitors.
    Type: Application
    Filed: February 22, 2013
    Publication date: May 7, 2015
    Applicants: NOVARTIS AG, IRM LLC
    Inventors: Feng Cong, Huaixiang Hao, Mindy Hsin-I Hsieh, Xiaomo Jiang, Jun Liu, Nicholas Ng