Patents by Inventor Mineo Tsuruda
Mineo Tsuruda has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5162553Abstract: The present invention provides an industrially valuable method for preparing an optically active 3,4-dihydro-3,4-epoxy-2H-1-benzopyran compound which is useful as a starting material for an optically active benzopyran compound with antihypertensive, coronary blood flow-increasing activities and the like, and also provides a diastereometric ester compound with a 3-halo-4-hydroxy-2H-1-benzopyran compound which is useful as an intermediate for said epoxy compound.Type: GrantFiled: June 19, 1991Date of Patent: November 10, 1992Assignee: Yoshitomi Pharmaceutical Industries, Ltd.Inventors: Shinro Setoguchi, Mineo Tsuruda, Chiaki Kitami, Tsutomu Yamanaka
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Patent number: 5066816Abstract: The present invention provides an industrially valuable method for preparing an optically active 3,4-dihydro-3,4-epoxy-2H-1-benzopyran compound which is useful as a starting material for an optically active benzopyran compound with antihypertensive, coronary blood flow-increasing activities and the like, and also provides a diastereomeric ester compound with a 3-halo-4-hydroxy-2H-1-benzopyran compound which is useful as an intermediate for said epoxy compound.Type: GrantFiled: February 28, 1990Date of Patent: November 19, 1991Assignee: Yoshitomi Pharmaceutical Industries, Ltd.Inventors: Shinro Setoguchi, Mineo Tsuruda, Chiaki Kitami, Tsutomu Yamanaka
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Patent number: 4661603Abstract: .alpha.-(2,6-dimethyl-4-carboxyphenyl)-2-methyl-5-(1-imidazolyl)-benzenemet hanol, pharmaceutically acceptable metal salts forms thereof, acid addition salt forms thereof, amino acid addition salt forms thereof, hydrate forms thereof and mixtures thereof.Such compounds have inhibitory activities on biosynthesis of thromboxane A.sub.2, inhibitory activities on platelet aggregation, vasodilative activities and protective effects against liver disorders.Type: GrantFiled: January 29, 1986Date of Patent: April 28, 1987Assignee: Yoshitomi Pharmaceutical Industries, Ltd.Inventors: Mineo Tsuruda, Takanori Oe, Kazuyuki Kawasaki, Hiroshi Mikashima, Hiroshi Yasuda
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Patent number: 4581369Abstract: An imidazole derivative of the formula: ##STR1## wherein each of R.sup.1 and R.sup.4 is a hydrogen atom or a lower alkyl group; each of R.sup.2 and R.sup.3 is a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group, a lower alkoxy group, an aralkyloxy group, a nitro group or an amino group; A is --O--, --S--, --CH.dbd.CH-- pr --CH.dbd.N--; Z is an aryl group, a thienyl group, a pyridyl group or a furyl group, in which definition these aromatic (heterocyclic) rings may have 1 to 3 substituents, each substituent being independently selected from a halogen atom, a lower alkyl group, a cyclic alkyl group, a lower alkoxy group, a hydroxyl group, a carboxyl group, a lower alkoxycarbonyl group, a carboxy-lower-alkoxy group, a di-lower-alkylamino-lower-alkoxy group and a nitro group; and a pharmaceutically acceptable acid addition salt thereof, a method for preparing the same and a pharmaceutical composition containing such compound.Type: GrantFiled: October 31, 1983Date of Patent: April 8, 1986Assignee: Yoshitomi Pharmaceutical Industries, Ltd.Inventors: Mineo Tsuruda, Takanori Oe, Kazuyuki Kawasaki, Hiroshi Mikashima, Hiroshi Yasuda
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Patent number: 4465681Abstract: Pyridine derivatives of the formula: ##STR1## or pharmaceutically acceptable acid addition salts thereof, wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are the same or different and each represents hydrogen atom or lower alkyl group, or R.sup.1 and R.sup.2, or R.sup.3 and R.sup.4 together with the adjacent nitrogen atom form a heterocycle, A.sup.1 and A.sup.2 are the same or different and each represents alkylene or hydroxy-substituted alkylene group, Y.sup.1 and Y.sup.2 are the same or different and each represents oxygen or sulfur atom, and Z represents ##STR2## These compounds show pharmacological activities such as potentiating activity for leukocyte phagocytosis, potentiating activity for macrophage phagocytosis, potentiating activity for the production of rosette forming cells in the spleen and anti-adjuvant arthritis activity, and are useful as medicines.Type: GrantFiled: July 28, 1982Date of Patent: August 14, 1984Assignee: Yoshitomi Pharmaceutical Industries Ltd.Inventors: Takanori Oe, Mineo Tsuruda, Kazuhiro Goto, Masao Hisadome
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Patent number: 4085111Abstract: 1H-Tetrazole derivatives of the formula: ##STR1## and pharmaceutically acceptable salts thereof, wherein the ring P is pyridine ring; A is carbonyl, methylene or C.sub.2-4 alkylidene; Y is oxygen, sulfur or --N(R.sup.1)-- wherein R.sup.1 is hydrogen or C.sub.1-4 alkyl; each of X.sup.1 and X.sup.2 is hydrogen, halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, phenyl or substituted phenyl, any substitutent on the phenyl being halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy or trifluoromethy; and R is hydrogen, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, hydroxy-C.sub.1-4 alkyl, C.sub.1-4 alkoxy-C.sub.1-4 alkyl, carboxy-C.sub.1-4 alkyl, C.sub.1-4 alkoxycarbonyl-C.sub.1-4 alkyl or substituted or unsubstituted amino-C.sub.1-4 alkyl, any substituted amino being C.sub.1-4 alkyl- or di-C.sub.1-4 alkyl-amino, piperidino, 1-pyrrolidinyl, morpholino, 1-piperazinyl and 4-C.sub.1-4 alkyl-1-piperazinyl; are useful as antiallergic agents.Type: GrantFiled: May 20, 1975Date of Patent: April 18, 1978Assignee: Yoshitomi Pharmaceutical Industries, Ltd.Inventors: Takanori Oe, Mineo Tsuruda
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Patent number: 3974168Abstract: Compounds of the formula: ##SPC1##WhereinOf X.sup.1 and X.sup.2 is a hydrogen atom, a halogen atom or an alkyl group having 1 to 4 carbon atoms;R.sup.1 is a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, an alkenyl group having 2 to 4 carbon atoms, an alkynyl group having 2 to 4 carbon atoms or a group -B.sup.1 -R.sup.3 (wherein B.sup.1 is an alkylene group having 1 to 4 carbon atoms, and R.sup.3 is a carboxyl group, an alkoxycarbonyl group in which the alkoxy moiety has 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms or a di-alkyl-amino group in which each alkyl moiety has 1 to 4 carbon atoms);R.sup.2 is an alkyl group having 1 to 4 carbon atoms or a group -B.sup.2 -R.sup.4 (wherein B.sup.2 is an alkylene group having 2 to 4 carbon atoms, and R.sup.Type: GrantFiled: September 4, 1974Date of Patent: August 10, 1976Assignee: Yoshitomi Pharmaceutical Industries, Ltd.Inventors: Michio Nakanishi, Takanori Oe, Mineo Tsuruda
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Patent number: 3931205Abstract: Substituted alkanoic acids and derivatives thereof of the formula: ##SPC1##Wherein each of X.sup.1 and X.sup.2 is a hydrogen atom, a halogen atom, an alkyl group having 1 to 4 carbon atoms or an alkoxy group having 1 to 4 carbon atoms; each of R.sup.1 and R.sup.2 is a hydrogen atom or an alkyl group having 1 to 4 carbon atoms; A is a carbonyl group, a methylene group or an alkylidene group having 2 to 4 carbon atoms; Y is --O--, --S-- or --N(R)-- [wherein R is a hydrogen atom or an alkyl group having 1 to 4 carbon atoms]; Z is OH or Q--B--N(R.sup.3)(R.sup.4) [wherein Q is O (oxygen atom) or NH, B is an alkylene group having 1 to 4 carbon atoms and each of R.sup.3 and R.sup.4 is a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, or R.sup.3 and R.sup.Type: GrantFiled: July 18, 1973Date of Patent: January 6, 1976Assignee: Yoshitomi Pharmaceutical Industries, Ltd.Inventors: Michio Nakanishi, Takanori Oe, Mineo Tsuruda
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Patent number: 3931199Abstract: Heterocyclic compounds of the formula: ##SPC1##Wherein A is a carbonyl group, a methylene group or an alkylidene group having 2 to 4 carbon atoms; B is an oxygen atom, a sulfur atom or --N(R')-- (wherein R' is a hydrogen atom or an alkyl group having 1 to 4 carbon atoms); each of R.sup.1 and R.sup.2 is a hydrogen atom, a halogen atom, an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms or a phenyl group which may be substituted by a halogen atom, an alkyl group having 1 to 4 carbon atoms or an alkoxy group having 1 to 4 carbon atoms; X is an alkyl group having 1 to 4 carbon atoms, a cycloalkyl group having 3 to 6 carbon atoms or OM (wherein M is a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, a metal atom or NH.sub.4); and ring P represents a pyridine ring, are useful as anti-allergic agents.Type: GrantFiled: March 19, 1974Date of Patent: January 6, 1976Assignee: Yoshitomi Pharmaceutical Industries, Ltd.Inventors: Michio Nakanishi, Takanori Oe, Mineo Tsuruda