Abstract: A neurosteroid derivative having a structure as represented by formula (IV), or a deuteride, and a pharmaceutically acceptable salt thereof, and use thereof are provided. In the formula (IV), R1 is selected from the group consisting of hydrogen and C1-C12 alkyl; and R2 is selected from R—(C?O)—, wherein R is selected from the group consisting of hydrogen and C1-C12 alkyl.

Abstract: A pre-prodrug, comprising a drug, e.g., doxorubicin, which has off-target toxicity (e.g., cardiotoxicity) with respect to its antineoplastic activity, and an amine functionality of the drug incorporated into a disubstituted maleimide (DMI). The pre-prodrug may be linked to a targeting or de-targeting agent or a polar modulator, e.g., charged ligand, amino acid, peptide, etc., to increase therapeutic index. The pre-prodrug is hydrolyzed to the prodrug, having a disubstituted maleamic acid (DMA). A polar modulator such as glutamic acid prevents cellular uptake of the prodrug, but not the doxorubicin drug released from the prodrug after dissociation. The prodrug is pH sensitive, and below pH 7.0, tends to cleave to form free drug and cyclized maleic anhydride. Tumor environments tend to be more acidic, e.g., pH 6.8, than cardiac tissue, e.g., pH 7.4, and therefore the heart is spared while the drug is selectively released within a tumor.

Abstract: This application discloses an interactive service processing method and system, a device, and a storage medium, and belongs to the field of computer technologies. The method includes acquiring a video stream and interactive information corresponding to the video stream, the interactive information comprising an interactive timestamp and interactive data; determining a transmission mode corresponding to the interactive information, the transmission mode comprising one of transmission based on a network channel and transmission with a video stream fragment as a medium; transmitting the video stream to a target terminal; and transmitting the interactive information to the target terminal based on the transmission mode corresponding to the interactive information, the target terminal being configured to process interactive service on the video stream according to the interactive timestamp and the interactive data in the interactive information.

Abstract: This application discloses an interactive service processing method and system, a device, and a storage medium, and belongs to the field of computer technologies. The method includes acquiring a video stream and interactive information corresponding to the video stream, the interactive information comprising an interactive timestamp and interactive data; determining a transmission mode corresponding to the interactive information, the transmission mode comprising one of transmission based on a network channel and transmission with a video stream fragment as a medium; transmitting the video stream to a target terminal; and transmitting the interactive information to the target terminal based on the transmission mode corresponding to the interactive information, the target terminal being configured to process interactive service on the video stream according to the interactive timestamp and the interactive data in the interactive information.

Abstract: A pre-prodrug, comprising a drug, e.g., doxorubicin, which has off-target toxicity (e.g., cardiotoxicity) with respect to its antineoplastic activity, and an amine functionality of the drug incorporated into a disubstituted maleimide (DMI). The pre-prodrug may be linked to a targeting or de-targeting agent or a polar modulator, e.g., charged ligand, amino acid, peptide, etc., to increase therapeutic index. The pre-prodrug is hydrolyzed to the prodrug, having a disubstituted maleamic acid (DMA). A polar modulator such as glutamic acid prevents cellular uptake of the prodrug, but not the doxorubicin drug released from the prodrug after dissociation. The prodrug is pH sensitive, and below pH 7.0, tends to cleave to form free drug and cyclized maleic anhydride. Tumor environments tend to be more acidic, e.g., pH 6.8, than cardiac tissue, e.g., pH 7.4, and therefore the heart is spared while the drug is selectively released within a tumor.