Patents by Inventor Ming-Bo Wang

Ming-Bo Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210269800
    Abstract: The present invention relates to new double stranded RNA (dsRNA) structures and their use in gene silencing.
    Type: Application
    Filed: August 2, 2019
    Publication date: September 2, 2021
    Inventors: Neil Andrew SMITH, Ming Bo WANG, Daai ZHANG, Timothy James DORAN, Mark TIZARD, Annapurna Devi ALLU, Ian Kevin GREAVES, Lingling GAO, Jonathan Paul ANDERSON, Robert DE FEYTER
  • Publication number: 20200263174
    Abstract: The present invention relates to new double stranded RNA (dsRNA) structures and their use in gene silencing.
    Type: Application
    Filed: September 17, 2018
    Publication date: August 20, 2020
    Inventors: Neil Andrew SMITH, Ming-Bo WANG, Timothy James DORAN, Mark TIZARD, Annapurna Devi ALLU, Ian Kevin GREAVES, Lingling GAO, Jonathan Paul ANDERSON, Daai ZHANG, Robert DE FEYTER
  • Patent number: 10190127
    Abstract: Methods and means are provided for reducing the phenotypic expression of a nucleic acid of interest in eukaryotic cells by providing aberrant, preferably unpolyadenylated, target-specific RNA to the nucleus of the host cell. Preferably, the unpolyadenylated, target-specific RNA is provided by transcription of a chimeric gene comprising a promoter and a DNA region encoding the target-specific RNA.
    Type: Grant
    Filed: July 7, 2017
    Date of Patent: January 29, 2019
    Assignee: COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION
    Inventors: Peter Waterhouse, Ming-Bo Wang
  • Publication number: 20180179549
    Abstract: Methods and means are provided for reducing the phenotypic expression of a nucleic acid of interest in eukaryotic cells by providing aberrant, preferably unpolyadenylated, target-specific RNA to the nucleus of the host cell. Preferably, the unpolyadenylated, target-specific RNA is provided by transcription of a chimeric gene comprising a promoter and a DNA region encoding the target-specific RNA.
    Type: Application
    Filed: July 7, 2017
    Publication date: June 28, 2018
    Applicant: Commonwealth Scientific and Industrial Research Organisation
    Inventors: Peter Waterhouse, Ming-Bo Wang
  • Patent number: 9885038
    Abstract: Provided are methods and means to obtain improved gene silencing of target nucleic acids whereby at least two inhibitory RNA molecules are provided which are targeted to the same nucleic acid, but which are processed into short interfering RNA molecules through different processing pathways. Also provided are methods and means to obtain improved gene silencing of target nucleic acids whereby at least two inhibitory RNA molecules are provided which are targeted to different nucleic acids, but which are processed into short interfering RNA molecules through different processing pathways.
    Type: Grant
    Filed: March 17, 2015
    Date of Patent: February 6, 2018
    Assignee: Commonwealth Scientific & Industrial Research Organisation
    Inventors: Ming-Bo Wang, Peter Waterhouse
  • Patent number: 9708621
    Abstract: Methods and means are provided for reducing the phenotypic expression of a nucleic acid of interest in eukaryotic cells by providing aberrant, preferably unpolyadenylated, target-specific RNA to the nucleus of the host cell. Preferably, the unpolyadenylated, target-specific RNA is provided by transcription of a chimeric gene comprising a promoter and a DNA region encoding the target-specific RNA.
    Type: Grant
    Filed: July 15, 2016
    Date of Patent: July 18, 2017
    Assignee: COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION
    Inventors: Peter Michael Waterhouse, Ming-Bo Wang
  • Publication number: 20170114354
    Abstract: Methods and means are provided for reducing the phenotypic expression of a nucleic acid of interest in eucaryotic cells, particularly in plant cells, by introducing chimeric genes encoding sense and antisense RNA molecules directed towards the target nucleic acid, which are capable of forming a double stranded RNA region by base-pairing between the regions with sense and antisense nucleotide sequence or by introducing the RNA molecules themselves. Preferably, the RNA molecules comprises simultaneously both sense and antisense nucleotide sequence.
    Type: Application
    Filed: September 8, 2016
    Publication date: April 27, 2017
    Applicant: Commonwealth Scientific & Industrial Research Organisation
    Inventors: Peter Michael Waterhouse, Ming Bo Wang, Michael Wayne Graham
  • Publication number: 20160355833
    Abstract: Methods and means are provided for reducing the phenotypic expression of a nucleic acid of interest in eukaryotic cells by providing aberrant, preferably unpolyadenylated, target-specific RNA to the nucleus of the host cell. Preferably, the unpolyadenylated, target-specific RNA is provided by transcription of a chimeric gene comprising a promoter and a DNA region encoding the target-specific RNA.
    Type: Application
    Filed: July 15, 2016
    Publication date: December 8, 2016
    Inventors: Peter Michael Waterhouse, Ming-Bo Wang
  • Patent number: 9441239
    Abstract: Methods and means are provided for reducing the phenotypic expression of a nucleic acid of interest in eucaryotic cells, particularly in plant cells, by introducing chimeric genes encoding sense and antisense RNA molecules directed towards the target nucleic acid, which are capable of forming a double stranded RNA region by base-pairing between the regions with sense and antisense nucleotide sequence or by introducing the RNA molecules themselves. Preferably, the RNA molecules comprises simultaneously both sense and antisense nucleotide sequence.
    Type: Grant
    Filed: March 1, 2006
    Date of Patent: September 13, 2016
    Assignee: Commonwealth Scientific & Industrial Research Organisation
    Inventors: Peter Michael Waterhouse, Ming-Bo Wang, Michael Wayne Graham
  • Patent number: 9399777
    Abstract: Methods and means are provided for reducing the phenotypic expression of a nucleic acid of interest in eukaryotic cells, particularly in plant cells, by providing aberrant, preferably unpolyadenylated, target-specific RNA to the nucleus of the host cell. Preferably, the unpolyadenylated target-specific RNA is provided by transcription of a chimeric gene comprising a promoter, a DNA region encoding the target-specific RNA, a self-splicing ribozyme and a DNA region involved in 3? end formation and polyadenylation.
    Type: Grant
    Filed: April 22, 2011
    Date of Patent: July 26, 2016
    Assignee: Commonwealth Scientific & Industrial Research Organisation
    Inventors: Peter Michael Waterhouse, Ming-Bo Wang
  • Publication number: 20150259682
    Abstract: Provided are methods and means to obtain improved gene silencing of target nucleic acids whereby at least two inhibitory RNA molecules are provided which are targeted to the same nucleic acid, but which are processed into short interfering RNA molecules through different processing pathways. Also provided are methods and means to obtain improved gene silencing of target nucleic acids whereby at least two inhibitory RNA molecules are provided which are targeted to different nucleic acids, but which are processed into short interfering RNA molecules through different processing pathways.
    Type: Application
    Filed: March 17, 2015
    Publication date: September 17, 2015
    Inventors: Ming-Bo WANG, Peter WATERHOUSE
  • Patent number: 8716557
    Abstract: Methods for altering the N-glycosylation pattern of proteins in higher plants are provided. The methods comprise introducing into the plant a recombinant RNAi construct that provides for the inhibition of expression of ?1,3-fucosyltransferase (FucT) and ?1,2-xylosyltransferase (XylT) in a plant. Use of these RNAi constructs to inhibit or suppress expression of both of these enzymes, and isoforms thereof, advantageously provides for the production of endogenous and heterologous proteins having a “humanized” N-glycosylation pattern without impacting plant growth and development. Stably transformed higher plants having this protein N-glycosylation pattern are provided. Glycoprotein compositions, including monoclonal antibody compositions, having substantially homogeneous glycosylation profiles, and which are substantially homogeneous for the G0 glycoform, are also provided.
    Type: Grant
    Filed: January 17, 2007
    Date of Patent: May 6, 2014
    Assignee: Synthon Biopharmaceuticals B.V.
    Inventors: Lynn F. Dickey, Kevin M. Cox, Charles G. Peele, Ming-Bo Wang
  • Patent number: 8598332
    Abstract: Methods and means are provided for reducing the phenotypic expression of a nucleic acid of interest in eucaryotic cells, particularly in plant cells, by introducing chimeric genes encoding sense and antisense RNA molecules directed towards the target nucleic acid, which are capable of forming a double stranded RNA region by base-pairing between the regions with sense and antisense nucleotide sequence or by introducing the RNA molecules themselves. Preferably, the RNA molecules comprises simultaneously both sense and antisense nucleotide sequence.
    Type: Grant
    Filed: April 7, 1999
    Date of Patent: December 3, 2013
    Assignee: Bayer CropScience N.V.
    Inventors: Peter Michael Waterhouse, Ming-Bo Wang, Michael Wayne Graham, Neil A. Smith
  • Patent number: 8334374
    Abstract: Methods and means are provided for reducing the phenotypic expression of a nucleic acid of interest in eukaryotic cells, particularly in plant cells, by providing aberrant, preferably unpolyadenylated, target-specific RNA to the nucleus of the host cell. Preferably, the unpolyadenylated target-specific RNA is provided by transcription of a chimeric gene comprising a promoter, a DNA region encoding the target-specific RNA, a self-splicing ribozyme and a DNA region involved in 3? end formation and polyadenylation.
    Type: Grant
    Filed: May 17, 2012
    Date of Patent: December 18, 2012
    Assignee: Commonwealth Scientific and Industrial Research Organisation
    Inventors: Peter Michael Waterhouse, Ming-Bo Wang
  • Publication number: 20120276086
    Abstract: The invention pertains to anti-CD30 antibodies that lack fucosyl and xylosyl residues. The antibodies of the invention exhibit increased antibody-dependent cellular cytotoxicity (ADCC) activity, including the ability to lyse CD30-expressing cell lines that are not lysed by the fucosylated and xylosylated form of the antibodies. The invention also provides host cells that express the anti-CD30 antibodies that lack fucosyl and xylosyl residues, wherein the host cells are deficient for a fucosyltransferase and a xylosyltransferase. Methods of using the antibodies to inhibit the grown of CD30+ cells, such as tumor cells, are also provided.
    Type: Application
    Filed: April 18, 2012
    Publication date: November 1, 2012
    Applicants: MEDAREX, INC., BIOLEX THERAPEUTICS, INC.
    Inventors: Amelia Nancy BLACK, David B. PASSMORE, Mohan SRINIVASAN, Lynn F. DICKEY, Kevin M. COX, Charles G. PEELE, Ming-Bo WANG
  • Publication number: 20120270315
    Abstract: Methods and means are provided for reducing the phenotypic expression of a nucleic acid of interest in eukaryotic cells, particularly in plant cells, by providing aberrant, preferably unpolyadenylated, target-specific RNA to the nucleus of the host cell. Preferably, the unpolyadenylated target-specifc RNA is provided by transcription of a chimeric gene comprising a promoter, a DNA region encoding the target-specific RNA, a self-splicing ribozyme and a DNA region involved in 3? end formation and polyadenylation.
    Type: Application
    Filed: May 17, 2012
    Publication date: October 25, 2012
    Inventors: Peter Michael Waterhouse, Ming-Bo Wang
  • Publication number: 20120210469
    Abstract: Methods and means are provided for reducing the phenotypic expression of a nucleic acid of interest in eukaryotic cells, particularly in plant cells, by providing aberrant, preferably unpolyadenylated, target-specific RNA to the nucleus of the host cell. Preferably, the unpolyadenylated target-specific RNA is provided by transcription of a chimeric gene comprising a promoter, a DNA region encoding the target-specific RNA, a self-splicing ribozyme and a DNA region involved in 3? end formation and polyadenylation.
    Type: Application
    Filed: April 22, 2011
    Publication date: August 16, 2012
    Applicant: Commonwealth Scientific and Industrial Research Organisation
    Inventors: Peter Michael WATERHOUSE, Ming-Bo Wang
  • Patent number: 8183217
    Abstract: Methods and means are provided for reducing the phenotypic expression of a nucleic acid of interest in eukaryotic cells by providing aberrant, preferably unpolyadenylated, target-specific RNA to the nucleus of the host cell. Preferably, the unpolyadenylated, target-specific RNA is provided by transcription of a chimeric gene comprising a promoter and a DNA region encoding the target-specific RNA.
    Type: Grant
    Filed: July 13, 2005
    Date of Patent: May 22, 2012
    Assignee: Commonwealth Scientific and Industrial Research Organisation
    Inventors: Peter Michael Waterhouse, Ming-Bo Wang
  • Publication number: 20110231955
    Abstract: Methods and means are provided to increase the efficiency of gene silencing when using dsRNA sequences which have a stem length shorter than about 200 base pairs by providing chimeric genes encoding such dsRNA sequences with a promoter recognized by DNA dependent RNA polymerase III comprising all cis-acting promoter elements which interact with DNA dependent RNA polymerase III.
    Type: Application
    Filed: January 3, 2011
    Publication date: September 22, 2011
    Applicant: Commonwealth Scientific and Industrial Research Organisation
    Inventors: Ming Bo WANG, Christopher A. HELLIWELL, Peter M. WATERHOUSE
  • Publication number: 20110131668
    Abstract: Provided are methods and means to obtain improved gene silencing of target nucleic acids whereby at least two inhibitory RNA molecules are provided which are targeted to the same nucleic acid, but which are processed into short interfering RNA molecules through different processing pathways. Also provided are methods and means to obtain improved gene silencing of target nucleic acids whereby at least two inhibitory RNA molecules are provided which are targeted to different nucleic acids, but which are processed into short interfering RNA molecules through different processing pathways.
    Type: Application
    Filed: August 14, 2008
    Publication date: June 2, 2011
    Applicant: Commonwealth Scientific and Industrial Research Organisation
    Inventors: Ming-Bo Wang, Peter Waterhouse