Abstract: Disclosed is a multi-block copolyester ether thermoplastic elastomer foam prepared from an aromatic polyester compound and contains a short-chain structure, a long-chain structure and a residual functional group of a chain extender. The short-chain structure has both an aromatic dicarboxylic acid ethylene glycol ester block structure and an aromatic dicarboxylic acid butylene glycol ester block structure. The long-chain structure has a polyether diol block structure. Based on 100 parts by weight of the multi-block copolyester ether thermoplastic elastomer foam, a content of the polyether diol block structure is 45 parts by weight to 65 parts by weight. The multi-block copolyester ether thermoplastic elastomer foam has a melting point not higher than 170° C. and a melt flow index less than 20 g/10 min.