Abstract: Certain aspects of an apparatus and method for automatic ER/PR scoring of tissue samples may include for determining a cancer diagnosis score comprising identifying a positive stained nucleus in a slide image of the tissue sample, identifying a negative stained nucleus in the slide image, computing a proportion score based on number of the positive stained nucleus identified and number of the negative stained nucleus identified and determining the cancer diagnosis score based on the proportion.

Abstract: Certain aspects of an apparatus and method for method and apparatus for automatic HER2 scoring of tissue samples may include for determining a cancer diagnosis score comprising identifying one or more nuclei in a slide image of a tissue sample, determine one or more membrane strengths in the slide image surrounding each of the one or more nuclei, classifying one or more cells, each corresponding to the one or more nuclei, in a class among a plurality of classes according to the one or more membrane strengths and determining a cancer diagnosis score based on a percentage of cells classified in each of the plurality of classes.

Abstract: A method and apparatus for simulating depth of field (DOF) in microscopic imaging, the method comprising computing a blur quantity for each pixel of an all-focus image, performing point spread function operations on one or more regions of the all-focus image, computing intermediate and normalized integral images on the regions and determining an output pixel for the each pixel based on the intermediate and normalized integral images.

Abstract: A method for improving depth for field (DOF) in microscopic imaging, the method comprising combining a sequence of images captured from different focal distances to form an all-focus image, comprising computing a focus measure at every pixel, finding the largest peaks at each position in the focus measure as multiple candidate values and blending the multiple candidates values according to the focus measure to determine the all-focus image.

Abstract: Certain aspects of an apparatus and method for method and apparatus for tissue region identification may include segmenting the image into a plurality of regions, filtering out regions in the plurality of regions which are curvilinear, and isolating a target area where the tissue sample is identified as the plurality of regions not filtered.

Abstract: A method and system to improve the performance of phase correlation motion estimation for low-bit-precision implementation are described herein. Phase correlation uses the Fast Fourier Transform (FFT) with operations with infinite-precision constants. Since physical implementations use finite-precision arithmetic, there is some loss in precision relative to the ideal infinite-precision case. In low-complexity implementations, it is desirable to use as few bits as possible, and if the precision is too low, the performance of traditional phase correlation suffers. A pre-processing technique is applied to the data prior to taking the FFT, which minimizes the negative effects of finite precision in the FFT and allows high quality results from phase correlation. The pre-processing step is a content-dependent contrast adjustment that maps the range of the input images' pixel values to the range of input values for the FFT. There is no post-processing required after the FFT to compensate for the pre-processing step.

Abstract: A system and method for effectively performing an integrated segmentation procedure comprises an image segmenter that includes a texture modeler, a contrast modeler, and a model integrator. The texture modeler creates a texture model based upon an original image. Similarly, the contrast modeler creates a contrast model based upon the original image. The model integrator then performs a model integration procedure to create a final segmented image by integrating the texture model and the contrast model according to a calculated texture model metric. A processor of an electronic device typically controls the image segmenter to perform the integrated segmentation procedure.

Abstract: A system for performing a scene representation procedure includes an image manager that processes source images from a given scene to define subscenes in the source images. The image manager creates an image understanding graph for each of the source images, and also creates a scene representation graph for each of the source images based upon the corresponding subscenes and certain image characteristics. The image manager further generates an integrated scene representation to represent all of the source images with a single representation. A processor of an electronic device controls the image manager to perform the scene representation procedure.

Abstract: A method of improving accuracy and reliability of motion estimation is described herein. In one aspect, a 2D neighborhood of phase correlation peak is approximated with an outer-product of two 1D vectors to eliminate the sub-pixel error. In another aspect, estimation of reliability is improved. In yet another aspect, two-pass phase correlation is implemented to eliminate sub-pel motion bias.

Abstract: Phase correlation is an established method for computing motion which relies on the ability to find peaks in a computed phase correlation surface. Two methods to improve the ability to detect peaks in the phase correlation surface are described herein. The first method applies a theoretically-derived and spatially-varying gain to the phase correlation surface. The gain compensates for peaks whose amplitudes have been decreased due to windowing effects; such effects are unavoidable in phase correlation. The second method uses concepts from matched filters to improve detection of peaks whose amplitudes are diminished due to a spreading of the peak energy into surrounding positions in the phase correlation surface. Peak detection filters allow such low-amplitude peaks to be properly detected. It is possible to use only the first method, or only the second method or both methods combined.

Abstract: Certain aspects of an apparatus and method for orienting tissue samples for comparison may include incrementally rotating orientation of a first image by a predetermined rotation angle while maintaining orientation of a second image at a fixed angle, checking alignment of the orientation of the first image with the orientation of the second image at each predetermined rotation angle by matching a plurality of points in the first image and the second image, determining whether a predetermined rotation angle is a correct rotation angle for alignment based on a count of the plurality of points being greater than a threshold value and rotating to the next predetermined rotation angle when the count of the plurality of points is less than or equal to a threshold value.

Abstract: A method and apparatus for compressing Z-stack microscopy images comprising compressing an all-focus image and depth map representation of an original Z-stack of images, computing a prediction residual as a difference between a simulated Z-stack, generated from the all-focus image and the depth-map, and the original Z-stack and concatenating the prediction residual to the compressed all-focus image and the depth map to produce a final compressed file.

Abstract: A method of improving accuracy and reliability of motion estimation is described herein. In one aspect, a 2D neighborhood of phase correlation peak is approximated with an outer-product of two 1D vectors to eliminate the sub-pixel error. In another aspect, estimation of reliability is improved. In yet another aspect, two-pass phase correlation is implemented to eliminate sub-pel motion bias.

Abstract: A method for detecting presence of a hand gesture in video frames includes receiving video frames having an original resolution, downscaling the received video frames into video frames having a lower resolution, and detecting a motion corresponding to the predefined hand gesture in the downscaled video frames based on temporal motion information in the downscaled video frames. The method also includes detecting a hand shape corresponding to the predefined hand gesture in a candidate search window within one of the downscaled video frames using a binary classifier. The candidate search window corresponds to a motion region containing the detected motion. The method further includes determining whether the received video frames contain the predefined hand gesture based on the hand shape detection.

Abstract: A method for synchronizing navigation in pathology stain images includes (a) downscaling the pathology stain images, (b) estimating rotation of the downscaled images, (c) aligning the downscaled images to generate aligned coordinates, and (d) transforming the aligned coordinates to original image coordinates in the pathology stain images to thereby generate alignment data. Also provided is a system for synchronized navigation in pathology stain images having original resolutions comprising a downscaler, a rotation estimator, an alignment module, and a coordinate transformer. The system may also include an image display system to display corresponding areas of the pathology stain images.

Abstract: A stain separation system of digital pathology images that performs transforming a digital image from a first color domain to an optical domain to form an optical domain image (ODI), identifying a plane containing two or more basis vector which contain the pixels of the ODI, determining a plurality of orthogonal vector within the identified plane, forming a histogram of the digital image represented by the orthogonal vectors and determining one or more final stain vectors by searching for candidate vectors in the plane that minimize a cost function of the histogram.

Abstract: Systems and methods are disclosed for estimating a vanishing point within an image, including: programming executable on a processor for computing line segment estimation of one or more lines in an image, wherein one or more of the lines is made up of multiple line segments as a single least-mean-square-error (LMSE) fitted line. Additionally, the one or more lines having multiple line segments are represented as a single least-mean-square-error (LMSE) fitted line, and the one or more lines are intersected to locate a vanishing point in a density space.

Abstract: Certain aspects of an apparatus and method for method and apparatus for tissue region identification may include segmenting the image into a plurality of regions, filtering out regions in the plurality of regions which are curvilinear, and isolating a target area where the tissue sample is identified as the plurality of regions not filtered.

Abstract: Certain aspects of an apparatus and method for orienting tissue samples for comparison may include incrementally rotating orientation of a first image by a predetermined rotation angle while maintaining orientation of a second image at a fixed angle, checking alignment of the orientation of the first image with the orientation of the second image at each predetermined rotation angle by matching a plurality of points in the first image and the second image, determining whether a predetermined rotation angle is a correct rotation angle for alignment based on a count of the plurality of points being greater than a threshold value and rotating to the next predetermined rotation angle when the count of the plurality of points is less than or equal to a threshold value.

Abstract: Certain aspects of an apparatus and method for gesture recognition using a two Dimensional (2D) imaging device may include capturing a first image of a hand in a first position, capturing a second image of the hand in a second position, generating an image mask for indicating the movement of the arm from the first position to the second position, determining an elbow position corresponding to the hand based on the image mask and estimating the change in depth of the hand from the first position to the second position based on the determined elbow position.