Patents by Inventor Ming-Che Shih

Ming-Che Shih has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • EPIGENETIC DISCRIMINATION OF DNA
    Publication number: 20200283840
    Abstract: The invention relates to methods of utilizing epigenetic information to separate one type of DNA from a mixture of multiple DNAs. The applications of the methods of the invention include, for example, the detection of chromosomal abnormality (e.g., aneuploidy, cancer cells), identification of genome abnormality, direct detection of DNA with abnormal copy number and development of indicators for the above-mentioned detection and identification.
    Type: Application
    Filed: August 15, 2017
    Publication date: September 10, 2020
    Inventors: Ming-Che SHIH, Pao-Yang CHEN, Ming-Ren YEN, Fei-Man HSU, Yi-Jing LEE
  • COMPOSITION AND METHOD FOR CONTROLLING INSECTS AND MICROORGANISMS USING PSEUDOMONAS TAIWANENSIS
    Publication number: 20200123495
    Abstract: Described herein are methods and compositions for controlling insects and microorganims growth using Pseudomonas taiwanensis and its culture broth.
    Type: Application
    Filed: October 25, 2019
    Publication date: April 23, 2020
    Inventors: Ming-Che Shih, Wen-Jen Chen, Je-Ruei Liu, Yu-Liang Yang
  • Engineered yeast for production of enzymes
    Patent number: 10087450
    Abstract: Described herein is an engineered Kluyveromyces marxianus cell, the cell comprising in its genome: (i) two different nucleic acid molecules that each contain a promoter operably linked to a gene encoding a functional enzyme, and (ii) a selection nucleic acid molecule that contains a promoter operably linked to a gene encoding a selectable marker, wherein all of the nucleic acids molecules of (i) and (ii) are in tandem and the engineered cell expresses all of the proteins encoded by the genes of (i) and (ii).
    Type: Grant
    Filed: May 17, 2016
    Date of Patent: October 2, 2018
    Assignee: Academia Sinica
    Inventors: Jui-Jen Chang, Wen-Hsiung Li, Chieh-Chen Huang, Hao-Yeh Lin, Ming-Che Shih
  • COMPOSITION AND METHOD FOR CONTROLLING INSECTS AND MICROORGANIMS USING PSEUDOMONAS TAIWANENSIS
    Publication number: 20170081632
    Abstract: Described herein are method and compositions for controlling insects and microorganisms growth using Pseudomonas taiwanensis and its culture broth.
    Type: Application
    Filed: June 10, 2015
    Publication date: March 23, 2017
    Inventors: Ming-Che Shih, Wen-Jen Chen, Je-Ruei Liu, Yu-Liang Yang
  • ENGINEERED YEAST FOR PRODUCTION OF ENZYMES
    Publication number: 20160251663
    Abstract: Described herein is an engineered Kluyveromyces marxianus cell, the cell comprising in its genome: (i) two different nucleic acid molecules that each contain a promoter operably linked to a gene encoding a functional enzyme, and (ii) a selection nucleic acid molecule that contains a promoter operably linked to a gene encoding a selectable marker, wherein all of the nucleic acids molecules of (i) and (ii) are in tandem and the engineered cell expresses all of the proteins encoded by the genes of (i) and (ii).
    Type: Application
    Filed: May 17, 2016
    Publication date: September 1, 2016
    Inventors: Jui-Jen Chang, Wen-Hsiung Li, Chieh-Chen Huang, Hao-Yeh Lin, Ming-Che Shih
  • Method for ordering and introducing multiple genes into a genome
    Patent number: 9340794
    Abstract: Described is a method of introducing multiple nucleic acid molecules into the genome of a cell. The method includes providing a plurality of nucleic acid molecules, each of the plurality of nucleic acid molecules containing (a) a nucleic acid sequence operatively linked to a promoter sequence at the 5? end of the nucleic acid molecule, and (b) an overlapping sequence at the 3? end of the nucleic acid molecule.
    Type: Grant
    Filed: August 31, 2012
    Date of Patent: May 17, 2016
    Assignee: Academia Sinica
    Inventors: Jui-Jen Chang, Feng-Ju Ho, Cheng-Yu Ho, Wen-Hsiung Li, Ming-Che Shih, Chieh-Chen Huang
  • Method for Ordering and Introducing Multiple Genes Into A Genome
    Publication number: 20140248703
    Abstract: Described is a method of introducing multiple nucleic acid molecules into the genome of a cell. The method includes providing a plurality of nucleic acid molecules, each of the plurality of nucleic acid molecules containing (a) a nucleic acid sequence operatively linked to a promoter sequence at the 5? end of the nucleic acid molecule, and (b) an overlapping sequence at the 3? end of the nucleic acid molecule.
    Type: Application
    Filed: August 31, 2012
    Publication date: September 4, 2014
    Applicant: Academia Sinica
    Inventors: Jui-Jen Chang, Feng-Ju Ho, Cheng-Yu Ho, Wen-Hsiung Li, Ming-Che Shih, Chieh-Chen Huang
  • Flavor compound-producing yeast strains
    Patent number: 8703474
    Abstract: Disclosed are a novel flavor compound-producing yeast strain and methods of using the strain to produce flavor compounds.
    Type: Grant
    Filed: August 16, 2011
    Date of Patent: April 22, 2014
    Assignee: Academia Sinica
    Inventors: Jui-Jen Chang, Cheng-Yu Ho, Chieh-Chen Huang, Ming-Che Shih, Wen-Hsiung Li
  • Expression system for producing multi-enzyme complexes and uses thereof
    Patent number: 8431371
    Abstract: An expression system for producing a multi-enzyme complex, the system including a nucleic acid molecule containing a promoter operatively linked to a nucleotide sequence including multiple genes encoding multiple enzymes that are components of the multi-enzyme complex.
    Type: Grant
    Filed: November 29, 2011
    Date of Patent: April 30, 2013
    Assignee: Academia Sinica
    Inventors: Wen-Hsiung Li, Ming-Che Shih, Chieh-Chen Huang, Jui-Jen Chang, Cheng-Yu Ho
  • Method for producing extracellular multi-enzyme complexes in host cells
    Patent number: 8354266
    Abstract: A polycistronic expression cassette encoding proteins necessary for constructing a multi-enzyme complex was developed. Also disclosed herein is a host cell containing this polycistronic expression cassette and uses thereof in degrading biomass.
    Type: Grant
    Filed: November 19, 2009
    Date of Patent: January 15, 2013
    Assignee: Academia Sinica
    Inventors: Wen-Hsiung Li, Ming-Che Shih, Chieh-Chen Huang, Jui-Jen Chang, Cheng-Yu Ho
  • Expression System for Producing Multi-Enzyme Complexes and Uses Thereof
    Publication number: 20120083012
    Abstract: An expression system for producing a multi-enzyme complex, the system including a nucleic acid molecule containing a promoter operatively linked to a nucleotide sequence including multiple genes encoding multiple enzymes that are components of the multi-enzyme complex.
    Type: Application
    Filed: November 29, 2011
    Publication date: April 5, 2012
    Applicant: Academia Sinica
    Inventors: Jui-Jen Chang, Cheng-Yu Ho, Ming-Che Shih, Chieh-Chen Huang, Wen-Hsiung Li
  • Flavor Compound-Producing Yeast Strains
    Publication number: 20120040420
    Abstract: Disclosed are a novel flavor compound-producing yeast strain and methods of using the strain to produce flavor compounds.
    Type: Application
    Filed: August 16, 2011
    Publication date: February 16, 2012
    Applicant: Academia Sinica
    Inventors: Jui-Jen Chang, Cheng-Yu Ho, Chieh-Chen Huang, Ming-Che Shih, Wen-Hsiung Li
  • Method for Producing Extracellular Multi-Enzyme Complexes in Host Cells
    Publication number: 20110117630
    Abstract: A polycistronic expression cassette encoding proteins necessary for constructing a multi-enzyme complex was developed. Also disclosed herein is a host cell containing this polycistronic expression cassette and uses thereof in degrading biomass.
    Type: Application
    Filed: November 19, 2009
    Publication date: May 19, 2011
    Applicant: Academia Sinica
    Inventors: Wen-Hsiung Li, Ming-Che Shih, Chieh-Chen Huang, Jui-Jen Chang, Cheng-Yu Ho