Abstract: The present invention provides improved processes for purifying semaglutide or liraglutide. Semaglutide or liraglutide is purified via two sequential RP-HPLC purifications followed by a salt-exchange step, where a pH is kept constant in the first and second purification steps. In particular, the processes utilize a halogenated solvent in a sample preparation step, which provides better solubility and an environment suitable for decarboxylation for crude semaglutide or liraglutide prior to a RP-HPLC purification.

Abstract: The present disclosure provides an improved process for the preparation of glucagon-like peptide-1 agonist peptide. Specifically, it relates to a manufacturing process useful for reducing impurities and increasing the yields and the balance of cost in the preparation of liraglutide or semaglutide.

Abstract: The present invention provides improved processes for purifying liraglutide. Liraglutide is purified via two sequential RP-HPLC purifications followed by a salt-exchange step, where a pH is kept constant in the first and second purification steps. In particular, the processes utilize a halogenated solvent in a sample preparation step, which provides better solubility and an environment suitable for decarboxylation for crude liraglutide prior to a RP-HPLC purification.

Abstract: The present invention provides improved processes for purifying semaglutide or liraglutide. Semaglutide or liraglutide is purified via two sequential RP-HPLC purifications followed by a salt-exchange step, where a pH is kept constant in the first and second purification steps. In particular, the processes utilize a halogenated solvent in a sample preparation step, which provides better solubility and an environment suitable for decarboxylation for crude semaglutide or liraglutide prior to a RP-HPLC purification.

Abstract: The present invention provides improved processes for purifying liraglutide. Liraglutide is purified via two sequential RP-HPLC purifications followed by a salt-exchange step, where a pH is kept constant in the first and second purification steps. In particular, the processes utilize a halogenated solvent in a sample preparation step, which provides better solubility and an environment suitable for decarboxylation for crude liraglutide prior to a RP-HPLC purification.

Abstract: Crystalline form S1 of lifitegrast characterized by a powder X-ray diffraction pattern with peaks at about 10.7±0.2, 16.2±0.2, 19.9±0.2, 22.1±0.2, 24.7±0.2, and 25.9±0.2 degrees two-theta, crystalline form S2 of lifitegrast characterized by a powder X-ray diffraction pattern with peaks at about 16.4±0.2, 24.9±0.2, and 26.2±0.2 degrees two-theta, and processes of making thereof are provided.

Abstract: Crystalline form S1 of lifitegrast characterized by a powder X-ray diffraction pattern with peaks at about 10.7±0.2, 16.2±0.2, 19.9±0.2, 22.1±0.2, 24.7±0.2, and 25.9±0.2 degrees two-theta, crystalline form S2 of lifitegrast characterized by a powder X-ray diffraction pattern with peaks at about 16.4±0.2, 24.9±0.2, and 26.2±0.2 degrees two-theta, and processes of making thereof are provided.

Abstract: The present disclosure provides efficient, economical, and improved processes for synthesizing lifitegrast and intermediates thereof. The currently discloses processes provide a direct synthetic route, avoiding protection or deprotection steps. The currently disclosed process also provides processes for synthesizing lifitegrast using a reduced number of synthetic steps.

Abstract: The present disclosure provides efficient, economical, and improved processes for synthesizing lifitegrast and intermediates thereof. The currently discloses processes provide a direct synthetic route, avoiding protection or deprotection steps. The currently disclosed process also provides processes for synthesizing lifitegrast using a reduced number of synthetic steps.

Abstract: An IP camera, a communication method and a communication system are provided. The IP camera includes an image capturing unit, a video processing unit and a connection processing unit. The image capturing unit captures a plurality of consecutive images. The video processing unit is coupled to the image capturing unit, and generates a first video stream and a second video stream according to the images. The connection processing unit is coupled to the video processing unit, processes the first video stream into a first packet stream, and processes the second video stream into a second packet stream. The connection processing unit transmits the first packet stream to a local area wireless network unit through a first wireless link, and the connection processing unit transmits the second packet stream to an external electronic device through a second wireless link.

Abstract: A portable electronic device with an exposed heat dissipating mechanism includes a housing and a heat dissipating plate. A heat generating unit is arranged inside the housing, and the heat dissipating plate includes a main body arranged inside the housing and at least one cooling portion extended from the main body and exposed on the housing. The main body and the heat generating unit are thermally connected to each other. Therefore, the effectiveness of the heat dissipation can be enhanced without increasing the thickness of the device and such that the need for heat dissipation in a portable electronic device of higher performance and computing power can be satisfied.

Abstract: An IP camera, a communication method and a communication system are provided. The IP camera includes an image capturing unit, a video processing unit and a connection processing unit. The image capturing unit captures a plurality of consecutive images. The video processing unit is coupled to the image capturing unit, and generates a first video stream and a second video stream according to the images. The connection processing unit is coupled to the video processing unit, processes the first video stream into a first packet stream, and processes the second video stream into a second packet stream. The connection processing unit transmits the first packet stream to a local area wireless network unit through a first wireless link, and the connection processing unit transmits the second packet stream to an external electronic device through a second wireless link.

Abstract: A network surveillance system, a wireless network surveillance apparatus, and a setting method of the wireless network surveillance apparatus are provided. The method includes following steps: obtaining at least one connection information for connecting a wireless network surveillance apparatus; connecting the wireless network surveillance apparatus according to the at least one connection information; obtaining an access point (AP) list and displaying the AP list on a user interface unit; after a user selects from the AP list a specific to-be-connected AP through the user interface unit and enters a password corresponding to the specific AP, controlling the wireless network surveillance apparatus to connect the specific AP through a wireless connection according to the password.

Abstract: A portable electronic device with an exposed heat dissipating mechanism includes a housing and a heat dissipating plate. A heat generating unit is arranged inside the housing, and the heat dissipating plate includes a main body arranged inside the housing and at least one cooling portion extended from the main body and exposed on the housing. The main body and the heat generating unit are thermally connected to each other. Therefore, the effectiveness of the heat dissipation can be enhanced without increasing the thickness of the device and such that the need for heat dissipation in a portable electronic device of higher performance and computing power can be satisfied.

Abstract: A handheld communication device with a heat dissipating structure includes a housing, a heat generating unit and a heat dissipator. The housing includes a chamber formed therein; the heat generating unit is received inside the chamber; the heat dissipator is arranged corresponding to the heat generating unit. The heat dissipator includes a heat pipe and a heat conductive plate. The heat pipe includes one end thermally attached to the heat generating unit and another end arranged away from the heat generating unit, and the heat conductive plate is thermally attached to the heat pipe. With such structure, the heat generated by the heat generating unit can be uniformly conducted to the heat conductive plate in order to prevent the accumulation of heat at the surrounding of the heat generating unit and to improve the efficiency of the heat dissipation of the device.