Abstract: In an image guidance method, a stream of cone-beam computed tomography (CBCT) images of an anatomical organ is acquired using a CBCT imaging device (34). For each CBCT image (44), the surface of the organ in the CBCT image is segmented to generate a segmented surface (70) of the anatomical organ in the CBCT image. Occluded shape reconstruction (66) using a statistical shape prior (68) may be used to reconstruct a missing or occluded surface portion. A pre-operative medical image (12) of the anatomical organ and the CBCT image are spatially registered by warping one of the images to the other of the images using point set registration of a segmented surface (30) of the organ in the preoperative medical image and the segmented surface of the organ in the CBCT image. A fused image (82) is displayed that combines the warped image and the other image.

Abstract: The present invention is directed towards a system and method for transarterial chemoembolization using differently sized drug-eluting microsphere beads filled with drugs and determining a delivered drug concentration using an imaging system.

Abstract: In an image guidance method, a stream of cone-beam computed tomography (CBCT) images of an anatomical organ is acquire using a CBCT imaging device (34). For each CBCT image (44), the surface of the organ in the CBCT image is segmented to generate a segmented surface (70) of the anatomical organ in the CBCT image. Occluded shape reconstruction (66) using a statistical shape prior (68) may be used to reconstruct a missing or occluded surface portion. A pre-operative medical image (12) of the anatomical organ and the CBCT image are spatially registered by warping one of the images to the other of the images using point set registration of a segmented surface (30) of the organ in the preoperative medical image and the segmented surface of the organ in the CBCT image. A fused image (82) is displayed that combines the warped image and the other image.

Abstract: An imaging system (100) includes a radiation source (108) that emits radiation that traverses an examination region and imageable drug eluting beads in tissue of interest located therein, a spectral detector array (110) detects radiation traversing the examination region and generates a signal indicative thereof, spectral processing circuitry (117) that spectrally resolves the signal based on a plurality of thresholds (122), and a reconstructor (128) that generates spectral volumetric image data corresponding the imageable drug eluting beads based on the spectrally resolved signal.

Abstract: The present invention is directed towards a system and method for transarterial chemoembolization using differently sized drug-eluting microsphere beads filled with drugs and determining a delivered drug concentration using an imaging system.

Abstract: A system for transcatheter arterial chemoembolization (TACE) includes a visualization software module (115) configured to assess vascular geometry of an organ in an image of the organ. A tumor viability software module (124) is configured to provide a tumor viability map of the organ to be overlaid on the image of the organ. An imaging modality (126) is configured to track an instrument in or in proximity of the organ to ensure that the instrument is positioned within the organ for treatment in accordance with the tumor viability map.

Abstract: A system (100) and method which assess the results of uterine fibroid embolization. A fibroid lesion is three-dimensionally segmented by a segmentation module (110) on contrast-enhanced arterial phase MRI or CBCT images and a differentiation process performed by a subtraction module (114) identifies actual contrast enhancement from background enhancement. The three-dimensional segmentation mask is then applied to the differentiated image and a region of interest is defined by a comparison module (116) in order to define a normalized threshold. A computation module (112) performs a voxel-by-voxel analysis of enhancing fibroid volume and quantifies the viable enhanced fibroid volume and overall fibroid volume in absolute numerical figures.

Abstract: An imaging system (100) includes a radiation source (108) that emits radiation that traverses an examination region and imageable drug eluting beads in tissue of interest located therein, a spectral detector array (110) detects radiation traversing the examination region and generates a signal indicative thereof, spectral processing circuitry (117) that spectrally resolves the signal based on a plurality of thresholds (122), and a reconstructor (128) that generates spectral volumetric image data corresponding the imageable drug eluting beads based on the spectrally resolved signal.

Abstract: The present invention relates to a device (2) for automatically quantifying intravascular embolization success, comprising a registration unit (4) adapted for registering a first image and a second image, a segmentation unit (6) adapted for segmenting a tissue of interest in the first image and in the second image and an evaluation unit (8) for evaluating a deviation of perfusion of the tissue of interest by comparing the first image and the second image. The first image is obtained before an interventional treatment, whereas the second image is obtained after such a treatment. Evaluating may comprise comparing the segments of the first and the second images and thus providing a quantitative measure for a perfusion deviation of the tissue, e.g. the perfusion deviation of a tumorous tissue before and after an embolization treatment.