Patents by Inventor Ming-Derg Lai

Ming-Derg Lai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RNAi compound targeted to thrombospondin-1 and applications thereof
    Patent number: 8377902
    Abstract: The present invention relates to an RNAi compound and an expression plasmid for inhibiting expression of Thrombospondin-1, which comprises a target sequence selected from Thrombospondin-1 gene. The present invention also related to a pharmaceutical composition comprising the RNAi compound and applications thereof. The RNAi compound can reduce the expression of Thrombospondin-1 to activate immune responses. In addition, the present invention also disclosed that an RNAi compound targeted to Thrombospondin-1 gene can delay tumor progression.
    Type: Grant
    Filed: January 6, 2011
    Date of Patent: February 19, 2013
    Assignee: National Cheng Kung University
    Inventors: Ming-Derg Lai, Shih-Shien Huang, Meng-Chi Yen, Chi-Chen Lin, Tzu-Yang Weng
  • RNAi COMPOUND TARGETED TO THROMBOSPONDIN-1 AND APPLICATIONS THEREOF
    Publication number: 20110166199
    Abstract: The present invention relates to an RNAi compound and an expression plasmid for inhibiting expression of Thrombospondin-1, which comprises a target sequence selected from Thrombospondin-1 gene. The present invention also related to a pharmaceutical composition comprising the RNAi compound and applications thereof. The RNAi compound can reduce the expression of Thrombospondin-1 to activate immune responses. In addition, the present invention also disclosed that an RNAi compound targeted to Thrombospondin-1 gene can delay tumor progression.
    Type: Application
    Filed: January 6, 2011
    Publication date: July 7, 2011
    Applicant: National Cheng Kung University
    Inventors: Ming-Derg Lai, Shih-Shien Huang, Meng-Chi Yen, Chi-Chen Lin, Tzu-Yang Weng
  • DNA vaccine containing tumor-associated gene and cytokine gene and method of preparation the same
    Patent number: 7132407
    Abstract: The present invention discloses a DNA vaccine and the method of preparation preparing the same, which employs DNA recombination technique to co-incorporate a fragment of tumor-associated gene and a fragment of cytokine gene into a vector. The administration of such DNA vaccine can enhance the immune response of the host through the co-expression of tumor-associated protein and cytokine, and thereby achieve the therapeutic effect of inhibiting or retarding tumor growth.
    Type: Grant
    Filed: September 16, 2003
    Date of Patent: November 7, 2006
    Assignee: National Cheng Kung University
    Inventors: Ming-Derg Lai, Chi-Chen Lin
  • DNA vaccine containing tumor-associated gene and cytokine gene and method of preparation the same
    Publication number: 20050020520
    Abstract: The present invention discloses a DNA vaccine and its method of preparation, which employs DNA recombination technique to co-incorporate a fragment of tumor-associated gene and a fragment of cytokine gene into a vector. The administration of such DNA vaccine may enhance the immune response of the host through the co-expression of tumor-associated antigen and cytokine, and thereby achieve the therapeutic effect of inhibiting or retarding tumor growth.
    Type: Application
    Filed: September 16, 2003
    Publication date: January 27, 2005
    Applicant: National Cheng Kung University
    Inventors: Ming-Derg Lai, Chi-Chen Lin
  • Antivirus RNA
    Publication number: 20040170963
    Abstract: An RNA molecule for inhibiting expression of a gene of a virus. Also disclosed are a DNA vector encoding the RNA molecule and a pharmaceutical composition containing the RNA molecule or vector and a pharmaceutically acceptable carrier, as well as methods for inhibiting expression of a gene of a virus, replication of the virus, and infection with the virus.
    Type: Application
    Filed: December 3, 2003
    Publication date: September 2, 2004
    Inventors: Ih-Jen Su, Wen-Tsan Chang, Huan-Yao Lei, Tsung-Lin Cheng, Wen-Wei Chang, Ming-Derg Lai, Wen-Ya Huang