Abstract: The invention discloses a method of forming an ESD protection device without adding the extra mask layers into the traditional CMOS process. At first, P-wells, N-wells, and isolations are formed in a semiconductor substrate. Next, an NMOS transistor with a gate dielectric layer, a gate electrode, source/drain regions, lightly doped source/drain regions, and insulator spacers is formed on the substrate. Particularly, N-wells are also formed in a part of the source/drain regions of the NMOS transistor. Thereafter, ESD protection regions are formed under the source/drain regions by performing P+ ESD protection implantation. Such ESD protection device has a low junction breakdown voltage, quick response speed, and a small junction capacitance.