Abstract: A simulation method of shield tunnel segment floating includes steps of dividing a flow field into grids, obtaining numbers and center coordinates of control bodies, and setting flow field boundary conditions; initializing flow field parameters and calculation parameters; updating the area velocity of the control bodies in the current time step; discretizing the flow field control equation, and solving iteratively the flow field velocity and pressure; updating the velocity and position coordinates of the boundary discrete points; obtaining the velocity of the boundary discrete points, calculating the force generated by the boundary discrete points and discretizing the force to the whole flow field; and finally transmitting the velocity of the boundary discrete points, the force applied to each unit of the flow field, the force applied to the boundary discrete points and the updated slurry viscosity in the current time step to the next time step.

Abstract: A friction resistance testing device for a side wall of a pipe jacking machine includes: a shell, a pressure gauge unit, a pulley (3) and a sensing block (4); wherein the pressure gauge unit, the pulley (3) and the sensing block (4) are provided in the shell (1); the pressure gauge unit is fixed to the shell (1); the pulley (3) is provided between the sensing block (4) and the pressure gauge unit; the sensing block (4) presses the pressure gauge unit in a horizontal direction to measure a side wall friction resistance; and the sensing block (4) presses the pressure gauge unit in a vertical direction to measure a soil pressure. The present invention further provides a method for adopting the friction resistance testing device for the side wall of the pipe jacking machine.

Abstract: An ultra-thin flexible vapor chamber and a preparation method and application thereof are provided. Based on projection micro stereolithography technology, the preparation method of the present disclosure enables preparation of the ultra-thin flexible vapor chamber of a micro-scale and high-precision ultra-thin dot matrix array structure with excellent liquid absorption and support capabilities. To improve properties of the vapor chamber, various dot matrix array structures including but not limited to a star-shaped array structure, a radial array structure and a parallel array structure, can be designed by topologically optimizing a distribution of the dot matrix array structure according to a location of a heat source. The ultra-thin flexible vapor chamber prepared herein not only meets requirements of an electronic device for a vapor chamber thickness and weight, but also features flexibility and bendability, stronger thermal conductivity, less thermal resistance and less energy consumption.

Abstract: The present application relates to a bi-functional therapeutic for treating cancer that includes a targeting component which targets a tumor-associated antigen and an enzyme which, when delivered to a tumor by said targeting component, converts the tumor phenotype to that of an incompatible allograft or xenograft. The enzyme is coupled to the targeting component. Also disclosed is a method for treating cancer comprising administering the bi-functional therapeutic.

Abstract: An ultra-thin flexible vapor chamber and a preparation method and application thereof are provided. Based on projection micro stereolithography technology, the preparation method of the present disclosure enables preparation of the ultra-thin flexible vapor chamber of a micro-scale and high-precision ultra-thin dot matrix array structure with excellent liquid absorption and support capabilities. To improve properties of the vapor chamber, various dot matrix array structures including but not limited to a star-shaped array structure, a radial array structure and a parallel array structure, can be designed by topologically optimizing a distribution of the dot matrix array structure according to a location of a heat source. The ultra-thin flexible vapor chamber prepared herein not only meets requirements of an electronic device for a vapor chamber thickness and weight, but also features flexibility and bendability, stronger thermal conductivity, less thermal resistance and less energy consumption.

Abstract: Knit scaffolds for culturing cells and aiding in the healing of functional tissue are provided. The knit scaffolds have properties aligned with specific tissues for providing optimal tissue growing surfaces including matched biomechanical properties. The scaffolds are made up of knitted material and do not require or utilize a support skeleton for function. Methods of making and using the knit scaffolds are also provided.

Abstract: Disclosed herein are a process for preparing alkynyl-containing compound and intermediate thereof.

Abstract: The present invention relates to a pharmaceutical composition comprising a sulfonamide as an inhibitor of Bcl-2/Bcl-xL, especially compound (3R)-1-(3-(4-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-4-methylsulfonyl-5-methyl-1H-pyrrol-3-yl)-5-fluorophenyl)piperazin-1-yl)-phenylaminosulfonyl)-2-trifluoromethyl sulfonyl-anilino)-4-phenylthio-butyl)-piperidine-4-carboxylic acid 3-phosphonopropyl ester or a pharmaceutically acceptable salt thereof and suitable excipients, preferably a pharmaceutical composition in the form of a lyophilized powder. The invention also relates to a method for preparing the pharmaceutical composition.

Abstract: The present application relates to a bi-functional therapeutic for treating cancer that includes a targeting component which targets a tumor-associated antigen and an enzyme which, when delivered to a tumor by said targeting component, converts the tumor phenotype to that of an incompatible allograft or xenograft. The enzyme is coupled to the targeting component. Also disclosed is a method for treating cancer comprising administering the bi-functional therapeutic.

Abstract: Disclosed is a method for preparing 2-indolinospirone compound and intermediate thereof, specifically disclosed is a method for preparing a compound of formula 5. The method is relatively simple and has high stereoselectivity and yield.

Abstract: Disclosed is a method for synthesizing N-(phenylsulfonyl)benzamide compound and intermediate thereof. The method comprises a method for synthesizing a compound 1, comprising conducting a Buchwald-Hartwig coupling reaction as shown below with compound A and compound B in a solvent and in the presence of a base and a palladium catalyst to obtain the compound 1; wherein R is C1-C8 alkyl. The present disclosure synthesizes three intermediate compounds required by the target compound and their preparation methods for the first time. Using the method disclosed in the present disclosure to synthesize the target compound 3 has the advantages of high yield, good purity, easy-to-obtain reaction raw materials, suitable for industrial production.

Abstract: The present invention relates to a method for preparing sulfonamides which are inhibitors of Bcl-2/Bcl-xL, comprising the compound (3R)-1-(3-(4-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-4-methylsulfonyl-5-methyl-1H-pyrrol-3-yl)-5-fluorophenyl)piperazin-1-yl)-phenylaminosulfonyl)-2-trifluoro methylsulfonyl-anilino)-4-phenylthio-butyl)-4-hydroxyl-piperidine, and the present invention also relates to intermediates for the preparation of the sulfonamides, a new final product and its therapeutic use, and pharmaceutical use.

Abstract: The present invention relates to a process for preparing a sulfonamide compound which is an inhibitor of Bcl-2/Bcl-xL, including the compound (3R)-1-(3-(4-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-4-methylsulfonyl-5-methyl-1H-pyrrol-3-yl)-5-fluorophenyl)piperazine-1-yl)-phenylaminosulfonyl)-2-trifluoromethanesulfonyl-anilino)-4-phenylthio-butyl)-piperidine-4-carboxylic acid 3-phosphonopropyl ester. The present invention also relates to an intermediate for preparing the sulfonamide compound and a preparation process thereof.

Abstract: The present invention discloses techniques for generating and presenting subtitles. The disclosed techniques comprise extracting target audio information from a video; converting the target audio information to first text information, wherein the target audio information and the first text information are in a first language; translating the first text information to at least one second text information, wherein the at least one second text information is in at least one second language; generating a first subtitle based on the first text information; generating at least one second subtitle based on the at least one second text information; obtaining a first target subtitle and at least one second target subtitle by implementing a sensitive word processing to the first subtitle and the at least one second subtitle, respectively; and presenting at least one of the first target subtitle or the at least one second target subtitle in response to user input.

Abstract: Disclosed herein are a process for preparing alkynyl-containing compound and intermediate thereof.

Abstract: The present invention relates to a process for preparing a sulfonamide compound which is an inhibitor of Bcl-2/Bcl-xL, including the compound (3R)-1-(3-(4-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-4-methylsulfonyl-5-methyl-1H-pyrrol-3-yl)-5-fluorophenyl)piperazine-1-yl)-phenylaminosulfonyl)-2-trifluoromethanesulfonyl-anilino)-4-phenylthio-butyl)-piperidine-4-carboxylic acid 3-phosphonopropyl ester. The present invention also relates to an intermediate for preparing the sulfonamide compound and a preparation process thereof.

Abstract: The present invention relates to a pharmaceutical composition comprising a sulfonamide as an inhibitor of Bcl-2/Bcl-xL, especially compound (3R)-1-(3-(4-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-4-methylsulfonyl-5-methyl-1H-pyrrol-3-yl)-5-fluorophenyl)piperazin-1-yl)-phenylaminosulfonyl)-2-trifluoromethyl sulfonyl-anilino)-4-phenylthio-butyl)-piperidine-4-carboxylic acid 3-phosphonopropyl ester or a pharmaceutically acceptable salt thereof and suitable excipients, preferably a pharmaceutical composition in the form of a lyophilized powder. The invention also relates to a method for preparing the pharmaceutical composition.

Abstract: Disclosed is a method for preparing 2-indolinospirone compound and intermediate thereof, specifically disclosed is a method for preparing a compound of formula 5, The method is relatively simple and has high stereoselectivity and yield.

Abstract: Embodiments of the present disclosure may relate to a digitized grating that may include a first unit cell that has a first period and a first length, where the first period includes a first grating element width and a first space between adjacent grating elements, and where the first length includes a number of first periods. The digitized grating may further include a second unit cell that has a second period and a second length, where the second period is different than the first period and includes a second grating element width and a second space between adjacent grating elements, and where the second length includes a number of second periods.

Abstract: The present invention relates to a method for preparing sulfonamides which are inhibitors of Bcl-2/Bcl-xL, comprising the compound (3R)-1-(3-(4-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-4-methylsulfonyl-5-methyl-1H-pyrrol-3-yl)-5-fluorophenyl)piperazin-1-yl)-phenylaminosulfonyl)-2-trifluoro methylsulfonyl-anilino)-4-phenylthio-butyl)-4-hydroxyl-piperidine, and the present invention also relates to intermediates for the preparation of the sulfonamides, a new final product and its therapeutic use, and pharmaceutical use.