Abstract: Described herein, inter alia, are imidazopyridine derivatives (I), pharmaceutically acceptable salts and tautomers thereof, compounds, combinations and medicaments containing said compounds and processes for their preparation. In embodiments, the imidazopyridine derivatives can be used as regulators of a stimulator of interferon genes (STING) and a related signal path thereof, and can effectively treat and/or relieve multiple types of diseases, including but not limited to malignant tumors, inflammations, autoimmune diseases, infectious diseases and as vaccine adjuvants.

Abstract: A virtual metrology method using a convolutional neural network (CNN) is provided. In this method, a dynamic time warping (DTW) algorithm is used to delete unsimilar sets of process data, and adjust the sets of process data to be of the same length, thereby enabling the CNN to be used for virtual metrology. A virtual metrology model of the embodiments of the present invention includes several CNN models and a conjecture model, in which plural inputs of the CNN model are sets of time sequence data of respective parameters, and plural outputs of the CNN models are inputs to the conjecture model.

Abstract: A Saccharomyces cerevisiae antibody display system that simultaneously secrets and displays antibody fragments from a very large size synthetic nave human antibody library for therapeutic antibody lead discovery and engineering is described. A bait anchor complexed with a monovalent antibody fragment is tethered on the surface of the S. cerevisiae host cell, wherein the fragment can be assayed for antigen binding, while the full bivalent antibody is simultaneously secreted from the host cell. Methods of using the system for identifying antibodies from the library that bind specifically to an antigen of interest are also provided. Polypeptides, polynucleotides and host cells used for making the antibody display system are also provided along with methods of use thereof.

Abstract: A virtual metrology method based on convolutional autoencoder and transfer learning includes performing a data alignment operation, a modeling operation and a calculating operation. The data alignment operation includes performing a data-length adjusting operation onto a plurality of sets of process data. The modeling operation includes classifying paired data and unpaired process data; creating a pre-trained model by using the unpaired process data, and then inputting the paired data to the pre-trained model to create a virtual metrology model based on convolutional autoencoder. The virtual metrology model based on convolutional autoencoder includes at least one convolutional neural network model. In addition, the calculating operation includes executing one of a predicting step and a transfer learning step according to whether the actual metrology data is obtained, thereby calculating one of a phase-one virtual metrology value and a phase-two virtual metrology value.

Abstract: An embodiment of the present disclosure provides a conversion circuit for converting a single-ended input to a differential input, which has fewer switches and fewer capacitors. This conversion circuit increases the signal-to-noise ratio (SNR), and the conversion circuit directly uses the higher supply voltage AVDD without being bucked by the regulator, wherein the common mode voltage is AVDD/2N, and N is greater than 1. Overall, not only the circuit area is smaller and the SNR is higher, but also the manufacturing cost is reduced. In addition, compared with the prior art, the conversion circuit of the embodiment of the present disclosure has only three operation periods, so the control is simpler and the operation speed is faster.

Abstract: Embodiments of the present disclosure provide a method for predicting an occurrence of a tool processing event, thereby determining whether to activate a virtual metrology. In a model-building stage, plural sets of model-building data are used to create at least one classification model in accordance with at least one classification algorithm, in which each classification model includes plural decision trees. Then, probabilities of the decision trees are used to create at least one reliance index model, and the sets of model-building data are used to create at least one similarity index model in accordance with a statistical distance algorithm. In a conjecture stage, a set of processing data of a workpiece is inputted into each classification model, each reliance index model and each similarity index model to determine whether to activate (start) virtual metrology.

Abstract: A power supply device for providing a driving voltage of an encryption/decryption device. When the encryption/decryption device is in operation and its driving voltage falls within the voltage range formed by an upper limit voltage and a lower limit voltage, only a supply voltage provided by a secure power supply device is used as the driving voltage for the encryption/decryption device. When the encryption and decryption device is in operation and its driving voltage falls outside the voltage range formed by the upper limit voltage and the lower limit voltage, the supply voltage and a stable voltage provided by the stable voltage source are used as the driving voltage at the same time, the supply voltage is further adjusted until the driving voltage falls within the voltage range formed by the upper limit voltage and the lower limit voltage, and then continue to use only the supply voltage as the driving voltage.

Abstract: A true random-number generator generating a random variable is provided. A first delay circuit delays an input signal to generate a first delayed signal. A second delay circuit delays the first delayed signal to generate a second delayed signal. A first sampling circuit samples the input signal according to a clock signal to generate a first sampled signal. A second sampling circuit samples the first delayed signal according to the clock signal to generate a second sampled signal. A third sampling circuit samples the second delayed signal according to the clock signal to generate a third sampled signal. An operational circuit generates the random variable and adjusts a count value according to the first sampled signal, the second sampled signal, and the third sampled signal. The operational circuit adjusts the clock signal according to the count value.

Abstract: Provided herein are anti-LAP antibodies (e.g., recombinant humanized, chimeric, and human anti-LAP antibodies) or antigen binding fragments thereof which have therapeutically beneficial properties, such as binding specifically to LAP-TGF?1 on cells but not to LAP-TGF?1 in extracellular matrix, as well as compositions including the same. Also provided are uses of these antibodies or antigen binding fragments in therapeutic applications, such as in the treatment of cancer, and diagnostic applications.

Abstract: Provided herein are high affinity antibodies or antigen binding fragments thereof that specifically bind to human tau-pS413. Also provided are compositions, kits, methods, and uses involving such antibodies or antigen binding fragments thereof.

Abstract: An incremental analog-to-digital converter including a first-stage non-delay memorization element and other elements is disclosed. An ending time point of a second reset signal received by the first-stage non-delay memorization element is later than an ending time point of a first reset signal received by the other elements by at least one clock cycle, a reset duration of the first-stage non-delay memorization element is longer than a reset duration of the other element, so that the first-stage non-delay memorization element can be prevented from occurring overshoot or spike on an output thereof, and the incremental analog-to-digital converter can maintain a good signal-to-noise and distortion ratio under the condition that the internal elements has low swing limits.

Abstract: Provided herein are high affinity antibodies or antigen binding fragments thereof that specifically bind to human tau-pS413. Also provided are compositions, kits, methods, and uses involving such antibodies or antigen binding fragments thereof.

Abstract: An intraoral scanning system is described herein. The intraoral scanning system includes a scanning device and a processing device. The scanning device is configured to illuminate an object of interest with a burst light pattern at one or more intervals and receive a set of reflected images reflected off the object of interest. The processing device is configured to receive the set of reflected images from the scanning device and convert the set of reflected images into a three-dimensional model of the object of interest. The burst light pattern comprises a first image and a second image in succession. One of the first image and the second image is a structured light image and the other of the first image and the second image is an unstructured light image.

Abstract: Provided herein are high affinity antibodies or antigen binding fragments thereof that specifically bind to human tau-pS413. Also provided are compositions, kits, methods, and uses involving such antibodies or antigen binding fragments thereof.

Abstract: A golden path search method for manufacturing process provides a two-phase process to search for a golden path. A first phase step of the two-phase process includes preparing a search model based on a search algorithm, and selecting a plurality of key process stages of a plurality of process stages by feeding sets of final inspection values and the production paths of the workpieces into the searching model, and then generating a plurality of key paths according to the key process stages. A second phase step of the two-phase process includes building a plurality of prediction models of the key paths according to the production paths and the sets of final inspection values, and predicting a plurality of yield rates corresponding to the key paths according to the prediction models, and then searching for the golden path of the key paths according to the yield rates.

Abstract: A power supply device for providing a driving voltage of an encryption/decryption device. When the encryption/decryption device is in operation and its driving voltage falls within the voltage range formed by an upper limit voltage and a lower limit voltage, only a supply voltage provided by a secure power supply device is used as the driving voltage for the encryption/decryption device. When the encryption and decryption device is in operation and its driving voltage falls outside the voltage range formed by the upper limit voltage and the lower limit voltage, the supply voltage and a stable voltage provided by the stable voltage source are used as the driving voltage at the same time, the supply voltage is further adjusted until the driving voltage falls within the voltage range formed by the upper limit voltage and the lower limit voltage, and then continue to use only the supply voltage as the driving voltage.

Abstract: Proteins that bind IL-1? and IL-1? are described along with their use in compositions and methods for treating, preventing, and diagnosing IL-1-related disorders and for detecting IL-1? and IL-1? in cells, tissues, samples, and compositions.

Abstract: A power supply device is provided with a secure power supply device, a voltage detection circuit, a stable voltage source and a switch. By using the voltage detection circuit, whether a driving voltage of an encryption/decryption device is insufficient to control the on and off the switch, so as to determine whether only the secure power supply device provides a supply voltage to the encryption/decryption device as the driving voltage. Alternatively, the supply voltage of the secure power supply device and a stable voltage of the stable voltage source are provided simultaneously to the encryption/decryption device as the driving voltage. In other words, once the driving voltage drops (that is, the encryption/decryption device consumes a large current for encryption/decryption), the stable voltage source immediately provides the stable voltage to the encryption/decryption device as part of the driving voltage to ensure that the encryption/decryption device can normally work.