Patents by Inventor Ming-Hsiung Yeh
Ming-Hsiung Yeh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11840719Abstract: An apparatus and associated methods of use for a controlled combination of reagents is disclosed. The apparatus includes a vessel 400, a vessel insert 220, and a cap element 200. The vessel 400 has a body portion 410 for receiving a biological sample. The vessel insert 220 receives at least one reagent therein. Preferably, the vessel insert 220 is received in a portion 420 of the vessel 400. The cap element 200 is attached to the vessel 400 to secure the vessel insert 220 in the vessel 400. During use, the vessel insert 220 is adapted to release its contents when the biological sample is introduced into the body portion 410 of the vessel 400 upon application of an intermixing force to the vessel insert 220. A variety of intermixing forces may be applied, depending upon the embodiment of the present invention and its associated methods of use.Type: GrantFiled: July 13, 2020Date of Patent: December 12, 2023Assignee: BECTON, DICKINSON AND COMPANYInventors: Mei Yang-Woytowitz, Brent Pohl, Gary F. Hershner, Dwight Livingston, Eric Ursprung, Gerard Lotz, Kevin Bailey, Ammon David Lentz, Michael A. Brasch, Ming-hsiung Yeh, Patrick Shawn Beaty, Charles C. Yu, Timothy M. Wiles, Liping Feng, Ben Turng, Xiaofei Chang, Patrick R. Murray
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Patent number: 11110416Abstract: A device for collecting a biological sample from a semi-solid surface. The device has a shaft with a proximate end and a distal end and a tip integrated with the shaft at the proximate end. The tip has a surface adapted to collect microorganisms thereon or release microorganism from, or both, wherein the adapted surface comprises at least one feature of a recess or extension to increase surface area of the tip and collect microorganisms thereon. Examples of such features include microfeatures with dimensions of about 1000 ?m or less. Other examples include a pipette tip.Type: GrantFiled: April 8, 2016Date of Patent: September 7, 2021Assignee: BECTON, DICKINSON AND COMPANYInventors: Timothy Mark Wiles, Dwight Livingston, Jennifer Singelyn, William Alan Fox, Brian Reuben Langhoff, Vikram Patel, Sean Tucker, Ming-hsiung Yeh, Michael A. Brasch
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Patent number: 11090228Abstract: Various embodiments of the present disclosure describe systems and methods for testing samples (e.g., biological samples, environmental samples, food samples etc.) for microbial contamination. For example, some embodiments describe an adapter assembly with a means to penetrate a septum of a collection vessel and permit gaseous communication between a headspace of the collection vessel and a sensor. In some embodiments, the gases in the headspace of the collection vessel can exit the collection vessel without contaminating the environment outside the system or allowing sample contamination. In some embodiments, the adapter assembly includes a membrane configured to prevent liquid in the collection vessel from contacting the sensor. In some embodiments, the adapter assembly can be used to access media inside the collection vessel for subculturing or aliquotting for another diagnostic process such as molecular diagnostics.Type: GrantFiled: August 18, 2017Date of Patent: August 17, 2021Assignee: BECTON DICKINSON AND COMPANYInventors: Ammon David Lentz, Brent D. Ludwig, Adam Steel, Ming-Hsiung Yeh
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Publication number: 20200340029Abstract: An apparatus and associated methods of use for a controlled combination of reagents is disclosed. The apparatus includes a vessel 400, a vessel insert 220, and a cap element 200. The vessel 400 has a body portion 410 for receiving a biological sample. The vessel insert 220 receives at least one reagent therein. Preferably, the vessel insert 220 is received in a portion 420 of the vessel 400. The cap element 200 is attached to the vessel 400 to secure the vessel insert 220 in the vessel 400. During use, the vessel insert 220 is adapted to release its contents when the biological sample is introduced into the body portion 410 of the vessel 400 upon application of an intermixing force to the vessel insert 220. A variety of intermixing forces may be applied, depending upon the embodiment of the present invention and its associated methods of use.Type: ApplicationFiled: July 13, 2020Publication date: October 29, 2020Inventors: Mei Yang-Woytowitz, Brent Pohl, Gary F. Hershner, Dwight Livingston, Eric Ursprung, Gerard Lotz, Kevin Bailey, Ammon David Lentz, Michael A. Brasch, Ming-hsiung Yeh, Patrick Shawn Beaty, Charles C. Yu, Timothy M. Wiles, Liping Feng, Ben Turng, Xiaofei Chang, Patrick R. Murray
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Patent number: 10767146Abstract: An apparatus and associated methods of use for a controlled combination of reagents is disclosed. The apparatus includes a vessel 400, a vessel insert 220, and a cap element 200. The vessel 400 has a body portion 410 for receiving a biological sample. The vessel insert 220 receives at least one reagent therein. Preferably, the vessel insert 220 is received in a portion 420 of the vessel 400. The cap element 200 is attached to the vessel 400 to secure the vessel insert 220 in the vessel 400. During use, the vessel insert 220 is adapted to release its contents when the biological sample is introduced into the body portion 410 of the vessel 400 upon application of an intermixing force to the vessel insert 220. A variety of intermixing forces may be applied, depending upon the embodiment of the present invention and its associated methods of use.Type: GrantFiled: October 24, 2014Date of Patent: September 8, 2020Assignee: BECTON, DICKINSON AND COMPANYInventors: Mei Yang-Woytowitz, Brent Pohl, Gary F. Hershner, Eric Ursprung, Michael A. Brasch, Ming-hsiung Yeh, Patrick Shawn Beaty, Charles C. Yu, Timothy M. Wiles, Liping Feng, Ben Turng, Xiaofei Chang, Patrick R. Murray
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Patent number: 10557163Abstract: Described herein are methods and apparatus for rapid detection of microorganisms in biological samples (e.g. blood) for analysis to determine the presence or absence of infectious microorganisms in the samples. The apparatus includes a cartridge with a lid and a tray, a mechanism for isolating a bulk sample into multiple smaller samples, and a sensor disposed on the tray to determine the presence or absence of microorganisms. The cartridge lid includes projections that, in a first position, allow for sample to distribute evenly in the cartridge tray and, in a second position, isolate the sample into multiple smaller volume samples. The apparatus and method shorten the time-to-detection of a microorganism in a sample and reduce the steps required from sample collection to microorganism detection.Type: GrantFiled: January 26, 2018Date of Patent: February 11, 2020Assignee: Becton Dickinson and CompanyInventor: Ming-Hsiung Yeh
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Publication number: 20190183730Abstract: Various embodiments of the present disclosure describe systems and methods for testing samples (e.g., biological samples, environmental samples, food samples etc.) for microbial contamination. For example, some embodiments describe an adapter assembly with a means to penetrate a septum of a collection vessel and permit gaseous communication between a headspace of the collection vessel and a sensor. In some embodiments, the gases in the headspace of the collection vessel can exit the collection vessel without contaminating the environment outside the system or allowing sample contamination. In some embodiments, the adapter assembly includes a membrane configured to prevent liquid in the collection vessel from contacting the sensor. In some embodiments, the adapter assembly can be used to access media inside the collection vessel for subculturing or aliquotting for another diagnostic process such as molecular diagnostics.Type: ApplicationFiled: August 18, 2017Publication date: June 20, 2019Applicant: BECTON DICKINSON AND COMPANYInventors: Ammon David Lentz, Brent D. Ludwig, Adam Steel, Ming-Hsiung Yeh
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Publication number: 20180148760Abstract: Described herein are methods and apparatus for rapid detection of microorganisms in biological samples (e.g. blood) for analysis to determine the presence or absence of infectious microorganisms in the samples. The apparatus includes a cartridge with a lid and a tray, a mechanism for isolating a bulk sample into multiple smaller samples, and a sensor disposed on the tray to determine the presence or absence of microorganisms. The cartridge lid includes projections that, in a first position, allow for sample to distribute evenly in the cartridge tray and, in a second position, isolate the sample into multiple smaller volume samples. The apparatus and method shorten the time-to-detection of a microorganism in a sample and reduce the steps required from sample collection to microorganism detection.Type: ApplicationFiled: January 26, 2018Publication date: May 31, 2018Applicant: Becton Dickinson and CompanyInventor: Ming-Hsiung Yeh
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Publication number: 20180126343Abstract: A device for collecting a biological sample from a semi-solid surface. The device has a shaft with a proximate end and a distal end and a tip integrated with the shaft at the proximate end. The tip has a surface adapted to collect microorganisms thereon or release microorganism from, or both, wherein the adapted surface comprises at least one feature of a recess or extension to increase surface area of the tip and collect microorganisms thereon. Examples of such features include microfeatures with dimensions of about 1000 ?m or less. Other examples include a pipette tip.Type: ApplicationFiled: April 8, 2016Publication date: May 10, 2018Applicant: Becton Dickinson and CompanyInventors: Timothy Mark WILES, Dwight LIVINGSTON, Jennifer SINGELYN, William Alan FOX, Brian Reuben LANGHOFF, Vikram PATEL, Sean TUCKER, Ming-hsiung YEH, Michael A. BRASCH
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Patent number: 9909162Abstract: Described herein are methods and apparatus for rapid detection of microorganisms in biological samples (e.g. blood) for analysis to determine the presence or absence of infectious microorganisms in the samples. The apparatus includes a cartridge with a lid and a tray, a mechanism for isolating a bulk sample into multiple smaller samples, and a sensor disposed on the tray to determine the presence or absence of microorganisms. The cartridge lid includes projections that, in a first position, allow for sample to distribute evenly in the cartridge tray and, in a second position, isolate the sample into multiple smaller volume samples. The apparatus and method shorten the time-to-detection of a microorganism in a sample and reduce the steps required from sample collection to microorganism detection.Type: GrantFiled: March 11, 2013Date of Patent: March 6, 2018Assignee: Becton, Dickinson and CompanyInventor: Ming-Hsiung Yeh
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Publication number: 20160265022Abstract: An apparatus and associated methods of use for a controlled combination of reagents is disclosed. The apparatus includes a vessel 400, a vessel insert 220, and a cap element 200. The vessel 400 has a body portion 410 for receiving a biological sample. The vessel insert 220 receives at least one reagent therein. Preferably, the vessel insert 220 is received in a portion 420 of the vessel 400. The cap element 200 is attached to the vessel 400 to secure the vessel insert 220 in the vessel 400. During use, the vessel insert 220 is adapted to release its contents when the biological sample is introduced into the body portion 410 of the vessel 400 upon application of an intermixing force to the vessel insert 220. A variety of intermixing forces may be applied, depending upon the embodiment of the present invention and its associated methods of use.Type: ApplicationFiled: October 24, 2014Publication date: September 15, 2016Applicant: BECTON, DICKINSON AND COMPANYInventors: Mei Yang-Woytowitz, Brent Pohl, Gary F. Hershner, Dwight Livingston, Eric Ursprung, Gerard Lotz, Kevin Bailey, Ammon David Lentz, Michael A. Brasch, Ming-hsiung Yeh, Patrick Shawn Beaty, Charles C. Yu, Timothy M. Wiles, Liping Feng, Ben Turng, Xiaofei Chang, Patrick R. Murray
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Publication number: 20160024549Abstract: Described herein are methods and apparatus for rapid detection of microorganisms in biological samples (e.g. blood) for analysis to determine the presence or absence of infectious microorganisms in the samples. The apparatus includes a cartridge with a lid and a tray, a mechanism for isolating a bulk sample into multiple smaller samples, and a sensor disposed on the tray to determine the presence or absence of microorganisms. The cartridge lid includes projections that, in a first position, allow for sample to distribute evenly in the cartridge tray and, in a second position, isolate the sample into multiple smaller volume samples. The apparatus and method shorten the time-to-detection of a microorganism in a sample and reduce the steps required from sample collection to microorganism detection.Type: ApplicationFiled: March 11, 2013Publication date: January 28, 2016Applicant: BECTON, DICKINSON AND COMPANYInventor: Ming-Hsiung Yeh
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Patent number: 6989246Abstract: The present invention is directed to a sensor system for monitoring metabolic activity of an anaerobic or aerobic microorganism. The present invention further relates to a sensor system that can individually and simultaneously monitor oxygen and carbon dioxide levels of a gas composition. Also provided is a sensor formulation for use with the sensor system of the present invention and a method of making the same.Type: GrantFiled: January 10, 2002Date of Patent: January 24, 2006Assignee: Becton, Dickinson and CompanyInventor: Ming-Hsiung Yeh
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Publication number: 20050037512Abstract: The present invention relates to compositions comprising a core and a hydrophobic coating material surrounding the core. The core comprises at least one oxygen-sensing particle. The present invention also relates to methods of detecting and monitoring oxygen in a sample using the microencapsulated oxygen-sensing particles.Type: ApplicationFiled: August 12, 2003Publication date: February 17, 2005Inventors: Ming-Hsiung Yeh, Jon Rowley, John Hemperly, Steven Keith, Mohammad Heidaran
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Publication number: 20030133123Abstract: The present invention is directed to a sensor system for monitoring metabolic activity of an anaerobic or aerobic microorganism. The present invention further relates to a sensor system that can individually and simultaneously monitor oxygen and carbon dioxide levels of a gas composition. Also provided is a sensor formulation for use with the sensor system of the present invention and a method of making the same.Type: ApplicationFiled: January 10, 2002Publication date: July 17, 2003Inventor: Ming-Hsiung Yeh
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Patent number: 6432697Abstract: The present invention relates to a transparent sample container containing, preferably, a liquid bacterial growth media for detecting microbacteria and a process for detecting microbacteria using this sample container. The container is optically transparent, heat resistant, and stable during storage. The container and process provide a bacterial growth medium substantially free of contamination upon prolonged storage of preferably about one year at 40° C.Type: GrantFiled: February 3, 2000Date of Patent: August 13, 2002Assignee: Becton, Dickinson and CompanyInventors: Gregory Tice, Ming-Hsiung Yeh, Thomas M. Gentle, Jr., Timothy M. Sullivan
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Patent number: 6432665Abstract: The present invention relates to a transparent sample container containing, preferably, a liquid bacterial growth media for detecting microbacteria and a process for detecting microbacteria using this sample container. The container is optically transparent, heat resistant, and stable during storage. The container and process provide a bacterial growth medium substantially free of contamination upon prolonged storage of preferably about one year at 40° C.Type: GrantFiled: February 3, 2000Date of Patent: August 13, 2002Assignee: Becton, Dickinson and CompanyInventors: Gregory Tice, Ming-Hsiung Yeh, Thomas M. Gentle, Jr., Timothy M. Sullivan
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Patent number: 5998517Abstract: The present invention relates to a composition for the detection of the growth of respiring microorganisms in a sample, which comprises:(a) tris(4,7-diphenyl-10-phenanthroline)ruthenium dichloride pentahydrate;(b) a hydroxyl functional group;(c) an organosilicon polymer;(d) an organohydrogensilicon compound; and(e) a catalyst;and a method for preparing said composition.Type: GrantFiled: June 5, 1998Date of Patent: December 7, 1999Assignee: Becton, Dickinson and CompanyInventors: Thomas M. Gentle, Jr., Ming-Hsiung Yeh
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Patent number: 5928794Abstract: This invention relates to the preparation of an addition curable composition having self adhesion to substrates. The addition curable composition comprises an organic polymer having on average at least 1.4 alkenyl groups per molecule, a crosslinker having on average at least 1.4 hydrosilyl groups per molecule, a platinum group metal containing catalyst, an alkoxy silicon compound and a titanium compound having Ti--O--C bonds. Another embodiment of this invention is a method of adhering the addition curable composition to a substrate surface.Type: GrantFiled: December 3, 1997Date of Patent: July 27, 1999Assignees: Dow Corning GmbH, Dow Corning CorporationInventors: Robert Edward Kalinowski, Mary Kay Tomalia, Andreas Thomas Franz Wolf, Ming Hsiung Yeh
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Patent number: 5858543Abstract: The present invention relates to the composition and preparation of composite films which exhibit low oxygen and flavor/aroma transmission rates. The film comprises a silane resin coated on a plastic substrate. The silane resin is formed from the mixture of a silane solution, an acrylate, a solvent, and optionally, either an additive, water or both. This invention teaches that a variety of silane solutions and acrylates may be mixed with different solvents to achieve the desired oxygen and flavor/aroma barrier characteristics.Type: GrantFiled: November 15, 1995Date of Patent: January 12, 1999Assignee: Dow Corning CorporationInventors: Daniel Edward Futter, Ming-Hsiung Yeh