Abstract: Compounds of formula (I) are described, wherein each of the variable groups is as defined in the specification. Also described are pharmaceutical compositions containing a compound of formula (I), and uses of the compounds and pharmaceutical compositions for inhibiting Nav1.8 voltage-gated sodium channels and treating Nav1.8 mediated diseases, disorders, and conditions, such as pain and pain-associated diseases, disorders, and conditions and cardiovascular diseases, disorders, and conditions, such as atrial fibrillation.

Abstract: A splash-proof device especially designed for but not limited to be using in a toilet bowl to prevent splash of soil water. The device includes a gutter ring having on the circumference thereof a plurality of segments between every two of which there is a segmental divider. A plurality of long arms and short arms are alternately snap-fitted onto corresponding segments so that the swinging amplitude thereof are confined within a predetermined range. Consequently, in case the feces fall onto the water surface between the arms, the surface area is too small to allow the occurrence of splashing, and provided the feces fall onto the arms of the gutter ring, the arms will provide a cushioning function thereby reducing the pulsive force of the falling feces and therefore, preventing the water from splashing upwards.