Abstract: Provided are a CLDN18.2-targeting antibody or an antigen-binding fragment thereof, a preparation method therefor, and the use thereof. The antibody comprises a light chain variable region and/or a heavy chain variable region, and the heavy chain variable region comprises HCDR1, HCDR2 and HCDR3, and the light chain variable region comprises LCDR1, LCDR2 and LCDR3. Compared with the prior art, the antibody has significant advantages in terms of binding affinity, ADCC, CDC, inhibitory effects on growth, endocytic activity, etc.

Abstract: A computer-implemented method for annotating images is disclosed. The computer-implemented method includes generating a saliency map corresponding to an input image, wherein the input image is an image that requires annotation, generating a behavior saliency map, wherein the behavior saliency map is a saliency map formed from an average of a plurality of objects contained within respective bounding boxes of a plurality of sample images, generating a historical saliency map, wherein the historical saliency map is a saliency map formed from an average of a plurality of tagged objects in the plurality of sample images, fusing the saliency map corresponding to the input image, the behavior saliency map, and the historical saliency map to form a fused saliency map, and generating, based on the fused saliency map, a bounding box around an object in the input image.

Abstract: A video playback buffer adjustment system is disclosed. The video playback buffer has a target size, measured in units of time of content, and includes a compressed frames queue and an uncompressed frames queue. The uncompressed frames queue has a minimum threshold queue size. If the size of the uncompressed frames queue falls below the minimum threshold size, then a next encoded frame in the compressed frames queue is removed from the compressed frames queue, decoded, and enqueued in the uncompressed frames queue. If a current size of the playback queue exceeds the target size plus ? (a hysteresis value), then a playback frame rate is increased, and a presentation time of one or more frames in the uncompressed frames queue is adjusted according to the increased playback frame rate. If the playback queue size is less than the target size minus ?, the playback speed can be reduced.

Abstract: The subject technology provides a messaging application in which an image can be captured and supplemented with supplemental content such as stickers, animations, etc., from within an active messaging thread. In this manner, a user participating in a messaging conversation with a remote user can add stickers, animations, and/or adaptive content to an image captured by the user, without having to locally cache/store the captured image before editing and without having to leave the messaging conversion (or the messaging application) to access an image editing application.

Abstract: A motor assembly is provided including a stator assembly and a rotor assembly rotatably disposed relative to the stator assembly. The rotor assembly includes a rotor core having magnet pockets formed therethrough along a longitudinal direction, permanent magnets received within the magnet pockets, and a spring structure disposed in contact with the end of the rotor core. The spring structure includes spring elements configured to apply biasing forces to the permanent magnets along the longitudinal direction of the magnet pockets. Optionally a magnet retention end cap is provided to secure the spring structure to the end of the rotor core.

Abstract: The present invention relates to a process for preparing a sulfonamide compound which is an inhibitor of Bcl-2/Bcl-xL, including the compound (3R)-1-(3-(4-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-4-methylsulfonyl-5-methyl-1H-pyrrol-3-yl)-5-fluorophenyl)piperazine-1-yl)-phenylaminosulfonyl)-2-trifluoromethanesulfonyl-anilino)-4-phenylthio-butyl)-piperidine-4-carboxylic acid 3-phosphonopropyl ester. The present invention also relates to an intermediate for preparing the sulfonamide compound and a preparation process thereof.

Abstract: Label-based document classification using artificial intelligence includes collecting, by one or more processors, a plurality of pre-trained classification models into a model pool and a plurality of documents into a document pool. The collected plurality of pre-trained classification models are applied in parallel to the plurality of documents in the document pool to generate a list of labels. Based on the list of labels, a final label result is generated according to which a baseline algorithm for document classification is generated by the one or more processors.

Abstract: The subject technology provides a messaging application in which an image can be captured and supplemented with supplemental content such as stickers, animations, etc., from within an active messaging thread. In this manner, a user participating in a messaging conversation with a remote user can add stickers, animations, and/or adaptive content to an image captured by the user, without having to locally cache/store the captured image before editing and without having to leave the messaging conversion (or the messaging application) to access an image editing application.

Abstract: A device implementing cellular communication protocol aware multimedia streaming may include at least one processor configured to establish a link for communicating with another device, wherein the link utilizes at least one of a first cellular communication protocol or a second cellular communication protocol. The at least one processor may be configured to determine a bit rate for a video stream to be provided to the other device based at least in part on whether the link utilizes the first cellular communication protocol or the second cellular communication protocol, wherein a first bit rate is determined when the link utilizes the first cellular communication protocol and a second bit rate is determined when the link utilizes the second cellular communication protocol. The at least one processor may be configured to provide, for transmission over the link to the other electronic device, the video stream at the determined bit rate.

Abstract: The present disclosure relates to the technical field of rock mechanics, and in particular to a method for accurately measuring a reopening pressure of hydraulic fracturing induced fracture in a deep borehole. The method includes: pumping a fluid into a sealed inner space of a drilling pipe for energy storage; and opening a valve at a lower end of the drilling pipe such that energy is released from the fluid in the inner space of the drilling pipe under the action of pressure to inject the fluid into a test interval. In the method according to the present disclosure, a fluid is pumped into an inner space of a drilling pipe so that the inner space of the drilling pipe is used as a high-pressure fluid pump to inject the fluid in the inner space of the drilling pipe to the test interval until the closed fracture is reopened.

Abstract: Disclosed is a system and method for providing program verify adaptation for flash memory. The method includes performing an adjustment iteration, which includes accessing error counts for respective N states of a plurality of memory cells, applying a weighting to the error counts based on a binary data coding for the N states, determining a state Smin of the N states having a minimum error count Emin from the error counts, determining a state Smax of the N states having a maximum error count Emax from the error counts, determining a difference between the Emax and the Emin satisfies an error count threshold, and adjusting, by a predefined value, a respective program verify offset of a lowest state from Smin and Smax, and of each state between Smin and Smax in the N states, wherein the adjusting is a decrement when Smin is less than Smax and an increment otherwise.

Abstract: The present invention relates to a process for preparing a sulfonamide compound which is an inhibitor of Bcl-2/Bcl-xL, including the compound (3R)-1-(3-(4-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-4-methylsulfonyl-5-methyl-1H-pyrrol-3-yl)-5-fluorophenyl)piperazine-1-yl)-phenylaminosulfonyl)-2-trifluoromethanesulfonyl-anilino)-4-phenylthio-butyl)-piperidine-4-carboxylic acid 3-phosphonopropyl ester. The present invention also relates to an intermediate for preparing the sulfonamide compound and a preparation process thereof.

Abstract: Techniques are disclosed relating to multiway communications. In some embodiments, a first electronic device initiates a multiway call between a plurality of electronic devices and exchanges a first secret with a first set of electronic devices participating during a first portion of the multiway call, the first secret being used to encrypt traffic between the first set of electronic devices. The first electronic device receives an indication that first set of participating electronic devices has changed and, in response to the indication, exchanges a second secret with a second set of electronic devices participating during a second portion of the multiway call, the second secret being used to encrypt traffic between the second set of participating electronic devices. In some embodiments, the indication identifies a second electronic device as leaving the multiway call, and the second secret is not exchanged with the second electronic device.

Abstract: A video playback buffer adjustment system is disclosed. The video playback buffer has a target size, measured in units of time of content, and includes a compressed frames queue and an uncompressed frames queue. The uncompressed frames queue has a minimum threshold queue size. If the size of the uncompressed frames queue falls below the minimum threshold size, then a next encoded frame in the compressed frames queue is removed from the compressed frames queue, decoded, and enqueued in the uncompressed frames queue. If a current size of the playback queue exceeds the target size plus ? (a hysteresis value), then a playback frame rate is increased, and a presentation time of one or more frames in the uncompressed frames queue is adjusted according to the increased playback frame rate. If the playback queue size is less than the target size minus ?, the playback speed can be reduced.

Abstract: A method and apparatus of a device that uses a video jitter buffer to buffer the video frames for a received video stream is described. The device uses the video jitter buffer to estimate the delay variability of the frames and pick a target delay that will help harmonize the playback with minimal loss and delay. This is achieved by estimating the delay spread, which is the result of performing statistical analysis of the measured lags of the video frames received. The video jitter buffer provides target delay recommendation and reference frame information to the video player in order to anchor the playback and schedule the frames presentation time.

Abstract: The embodiments described herein can dynamically adjust timing of network bandwidth estimations by adjusting a target frequency for sending probing sequences to one or more receivers of content. The receivers receive these probing sequences from a transmitter and respond to the transmitter with network bandwidth estimations. In one embodiment, the probing sequences can use the content itself to create the probing sequences. The embodiments can be used in video conferencing applications to control how a transmitter of content can adjust transmissions based upon the network bandwidth estimations. In one embodiment, a policy can be used at a transmitter to begin a video transmission with a high frequency target for sending probing sequences (with, e.g., smaller length probing sequences) and transition to a lower frequency target (with, e.g., longer length probing sequences) when network bandwidth deteriorates and then return to the higher frequency target when the network bandwidth improves.

Abstract: Disclosed is a system and method for providing program verify adaptation for flash memory. The method includes performing an adjustment iteration, which includes accessing error counts for respective N states of a plurality of memory cells, applying a weighting to the error counts based on a binary data coding for the N states, determining a state Smin of the N states having a minimum error count Emin from the error counts, determining a state Smax of the N states having a maximum error count Emax from the error counts, determining a difference between the Emax and the Emin satisfies an error count threshold, and adjusting, by a predefined value, a respective program verify offset of a lowest state from Smin and Smax, and of each state between Smin and Smax in the N states, wherein the adjusting is a decrement when Smin is less than Smax and an increment otherwise.

Abstract: Determining, by a machine learning model in an isolated operating environment, whether a file is safe for processing by a primary operating environment. The file is provided, when the determining indicates the file is safe for processing, to the primary operating environment for processing by the primary operating environment. When the determining indicates the file is unsafe for processing, the file is prevented from being processed by the primary operating environment. The isolated operating environment can be maintained on an isolated computing system remote from a primary computing system maintaining the primary operating system. The isolating computing system and the primary operating system can communicate over a cloud network.

Abstract: Provided herein are alpha5-containing GABAA receptor agonists and pharmaceutical compositions and methods of treatment of cognitive and mood symptoms in neurodegenerative and neuropsychiatric disorders using them.

Abstract: Techniques are disclosed relating to multiway communications. In some embodiments, a first electronic device initiates a multiway call between a plurality of electronic devices and exchanges a first secret with a first set of electronic devices participating during a first portion of the multiway call, the first secret being used to encrypt traffic between the first set of electronic devices. The first electronic device receives an indication that first set of participating electronic devices has changed and, in response to the indication, exchanges a second secret with a second set of electronic devices participating during a second portion of the multiway call, the second secret being used to encrypt traffic between the second set of participating electronic devices. In some embodiments, the indication identifies a second electronic device as leaving the multiway call, and the second secret is not exchanged with the second electronic device.