Patents by Inventor Ming-Jium Shieh

Ming-Jium Shieh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9949929
    Abstract: A drug carrier and a manufacturing method thereof are provided. The drug carrier includes a hydrophilic group, a hydrophobic group and an organic dye. The hydrophilic group and the hydrophobic group are connected by the organic dye. A plurality of the drug carriers are self-assemblable in a polar solvent to form a nanomicelle. The hydrophilic groups are located at the outer region of the nanomicelle, and the hydrophobic groups are located at the inner region of the nanomicelle.
    Type: Grant
    Filed: December 3, 2015
    Date of Patent: April 24, 2018
    Assignee: NATIONAL TAIWAN UNIVERSITY HOSPITAL
    Inventors: Ming-Jium Shieh, Cheng-Liang Peng, Yuan-I Chen
  • Publication number: 20170014344
    Abstract: A drug carrier and a manufacturing method thereof are provided. The drug carrier includes a hydrophilic group, a hydrophobic group and an organic dye. The hydrophilic group and the hydrophobic group are connected by the organic dye. A plurality of the drug carriers are self-assemblable in a polar solvent to form a nanomicelle. The hydrophilic groups are located at the outer region of the nanomicelle, and the hydrophobic groups are located at the inner region of the nanomicelle.
    Type: Application
    Filed: December 3, 2015
    Publication date: January 19, 2017
    Inventors: Ming-Jium SHIEH, Cheng-Liang Peng, Yuan-I Chen
  • Publication number: 20140356433
    Abstract: The present invention provides a pharmaceutical carrier and a drug structure using the carrier. The drug of the present invention comprises particular contents of chitosan, a negatively charged polymer, sodium tripolyphosphate, and an active ingredient, which combine with each other via electrostatic attraction. The drug structure has better release property and longer retention time; therefore overcomes the current drawbacks of the conventional treatment.
    Type: Application
    Filed: November 22, 2013
    Publication date: December 4, 2014
    Inventor: MING-JIUM SHIEH
  • Publication number: 20130336889
    Abstract: A nanoparticle for detecting or treating a tumor is provided. The nanoparticle includes a plurality of polymer backbones and at least one first detectable substance, of which each of the polymer backbones includes a hydrophobic region, a hydrophilic region and a chelating region, and the first detectable substance is bound to the chelating region of the polymer backbone. The hydrophobic regions of the polymer backbones form a core block, and the hydrophilic regions of the polymer backbones form a shell block surrounding the core block. A method for detecting or treating a tumor using the nanoparticle is also provided.
    Type: Application
    Filed: June 14, 2012
    Publication date: December 19, 2013
    Applicant: NATIONAL TAIWAN UNIVERSITY
    Inventors: Ming-Jium Shieh, Cheng-Liang Peng, Tsai-Yueh Luo
  • Publication number: 20130266508
    Abstract: A thermosensitive hydrogel for coating radioisotopes and chemotherapeutic agents to treat cancer and a method for preparing the same are revealed. The anticancer drugs such as radiopharmaceuticals or chemotherapeutic agents are coated with the hydrogel formed by PCL-PEG-PCL. By the feature of the hydrogel body that changes from liquid phase at low storage temperature to gel form at body temperature, not only the anticancer drugs can be injected into the human body and reaching the treatment site smoothly but the treatment time of brachytherapy is also extended. Thus the side effects of cancer therapy are significantly reduced.
    Type: Application
    Filed: April 9, 2012
    Publication date: October 10, 2013
    Applicant: ATOMIC ENERGY COUNCIL-INSTITUTE OF NUCLEAR ENERGY RESEARCH
    Inventors: Tsai-Yueh Luo, Cheng-Liang Peng, Ming-Jium Shieh, Ying-Hsia Shih, Chung-Hsin Yeh, I-Chung Tang