Patents by Inventor Ming-Lee Chu

Ming-Lee Chu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10504713
    Abstract: An ion trap mass spectrometer and methods for obtaining a mass spectrum of ions by scanning an RF frequency applied to the linear ion trap for mass selective ejection of the ions by using two power amplifiers to apply opposite phases of the RF to x and y electrodes.
    Type: Grant
    Filed: February 17, 2016
    Date of Patent: December 10, 2019
    Assignee: Academia Sinica
    Inventors: Chung-Hsuan Chen, I-Chung Lu, Ming-Lee Chu
  • Patent number: 9915614
    Abstract: Methods, systems, and devices are disclosed for molecular capture, manipulation, and analysis. In one aspect, a device to aggregate and characterize particles in a fluid includes an electrically insulative substrate including a channel to carry an electrically conducting fluid containing particles, electrodes located in the channel forming a nanoscale opening and including an insulating layer over their surface at the opening, a first circuit to apply a non-uniform ac electric field and a dc bias signal across the electrodes, in which the applied non-uniform ac electric field produces a positive dielectrophoretic force to aggregate the particles in a trapping region including the opening and adjacent region, a second circuit to detect changes in a dc current caused by at least some of the particles in the trapping region, and an optical device that directs a coherent light beam on the opening to determine Raman spectra of the particles in the trapping region.
    Type: Grant
    Filed: April 26, 2013
    Date of Patent: March 13, 2018
    Assignees: ACADEMIA SINICA, MAX-PLANCK-INSTITUT FUR EISENFORSCHUNG GMBH
    Inventors: Chia-Fu Chou, Lesser-Rojas Leonardo, Ming-Lee Chu, Andreas Erbe
  • Patent number: 9696391
    Abstract: A precision high-speed shuttle device for transporting samples between different positions of a superconducting magnet with different magnetic field strength is provided. The sample equilibrated at the center of the magnet, where the magnetic field is the highest and homogeneous, is shuttled to a higher position above, where the fringe field is lower, for a defined period of time and shuttled back to the center for detection. By shuttling the sample to different positions in the magnet in different experiments one can obtain a field-dependent profile of particular physical parameters. The position and timing of the sample are precisely under the experimental controlled. In this way various magnetic field-dependent nuclear magnetic resonance (NMR) experiments can be conducted in a single high-field NMR spectrometer.
    Type: Grant
    Filed: May 6, 2013
    Date of Patent: July 4, 2017
    Assignee: ACADEMIA SINICA
    Inventors: Tai-Huang Huang, Ching-Yu Chou, Ming-Lee Chu, Chi-Fon Chang
  • Patent number: 9609786
    Abstract: The present invention discloses a cooling system for an electronic rack, comprising: an electronic rack comprising at least one side wall; at least one electronic chassis comprising a top wall and at least one side wall and disposed inside the electronic rack for housing at least one modular electronics equipment comprising a plurality of electronic components and at least one stationary thermal interface arranged above the plurality of electronic components; a first detachable thermal interface arranged between the top wall of the at least one electronic chassis and the at least one modular electronic equipment; and at least one second detachable thermal interface arranged between the at least one side wall of the electronic rack and the at least one side wall of the at least one electronic chassis.
    Type: Grant
    Filed: August 26, 2014
    Date of Patent: March 28, 2017
    Assignee: ACADEMIA SINICA
    Inventors: Shih-Chang Lee, Ming-Lee Chu, Chih-Hsun Lin
  • Publication number: 20160163529
    Abstract: An ion trap mass spectrometer and methods for obtaining a mass spectrum of ions by scanning an RF frequency applied to the linear ion trap for mass selective ejection of the ions by using two power amplifiers to apply opposite phases of the RF to x and y electrodes.
    Type: Application
    Filed: February 17, 2016
    Publication date: June 9, 2016
    Inventors: Chung-Hsuan CHEN, I-Chung LU, Ming-Lee CHU
  • Patent number: 9285486
    Abstract: The invention relates to a method for radiation detection signal processing, and more particularly to a method capable of using a periodic signal to control the time of charging/discharging to a capacitor of an integrator. The method can be used for detecting the energy of incident photon of Gamma ray during the happening of an event while reducing dead time, and thereby, the count rate is increased. As the periodic signal is used as the signal for controlling the time of charging/discharging to a capacitor, the charging/discharging time of the integrator is no longer being controlled by the triggering time of the event, and thus, the present method is advantageous in that: the control method and circuit architecture are comparatively simpler since the charging/discharging time of the integrator no longer required to be controlled precisely, and thus the integration error due to insufficient resolution in delay element can be avoided.
    Type: Grant
    Filed: October 20, 2014
    Date of Patent: March 15, 2016
    Assignee: INSTITUTE OF NUCLEAR ENERGY RESEARCH ATOMIC ENERGY COUNCIL, EXECUTIVE YUAN
    Inventors: Sheng-Pin Tseng, Ming-Lee Chu, Meei-Ling Jan
  • Patent number: 9224586
    Abstract: Methods and apparatuses for portable mass spectrometry are disclosed. The apparatuses comprise at least one source of ionized analyte, at least one frequency scanning subsystem, at least one detector, and optionally at least one vacuum pump, and are portable. In some embodiments, the apparatuses comprise multiple sources of ionized analyte and/or are configured to obtain mass spectra of a large analyte, such as analyte with an m/z ratio of at least 105, or analyte with a molecular weight of at least 105 Da, as well as mass spectra of small molecule analyte. In some embodiments, the methods comprise obtaining mass spectra with a portable apparatus described above.
    Type: Grant
    Filed: December 22, 2010
    Date of Patent: December 29, 2015
    Assignee: Academia Sinica
    Inventors: Chung-Hsuan Chen, Jung-Lee Lin, Ming-Lee Chu
  • Publication number: 20150115167
    Abstract: The invention relates to a method for radiation detection signal processing, and more particularly to a method capable of using a periodic signal to control the time of charging/discharging to a capacitor of an integrator. The method can be used for detecting the energy of incident photon of Gamma ray during the happening of an event while reducing dead time, and thereby, the count rate is increased. As the periodic signal is used as the signal for controlling the time of charging/discharging to a capacitor, the charging/discharging time of the integrator is no longer being controlled by the triggering time of the event, and thus, the present method is advantageous in that: the control method and circuit architecture are comparatively simpler since the charging/discharging time of the integrator no longer required to be controlled precisely, and thus the integration error due to insufficient resolution in delay element can be avoided.
    Type: Application
    Filed: October 20, 2014
    Publication date: April 30, 2015
    Inventors: SHENG-PIN TSENG, MING-LEE CHU, MEEI-LING JAN
  • Patent number: 8963075
    Abstract: A novel system and method for charge-monitoring mass spectrometry is provided. The mass spectrometer can be used to measure the mass of one or more analytes having masses in the range of about a few Daltons to more than about 1015 Daltons. The invention can be used for rapid mass distribution measurements. For example, the system and method can be used to distinguish cancer cells from normal cells when their mass distributions are different.
    Type: Grant
    Filed: December 11, 2008
    Date of Patent: February 24, 2015
    Assignee: Academia Sinica
    Inventors: Chung Hsuan Chen, Wen-Ping Peng, Ming Lee Chu, Huan Cheng Chang, Huan-Chang Lin
  • Publication number: 20140362531
    Abstract: The present invention discloses a cooling system for an electronic rack, comprising: an electronic rack comprising at least one side wall; at least one electronic chassis comprising a top wall and at least one side wall and disposed inside the electronic rack for housing at least one modular electronics equipment comprising a plurality of electronic components and at least one stationary thermal interface arranged above the plurality of electronic components; a first detachable thermal interface arranged between the top wall of the at least one electronic chassis and the at least one modular electronic equipment; and at least one second detachable thermal interface arranged between the at least one side wall of the electronic rack and the at least one side wall of the at least one electronic chassis.
    Type: Application
    Filed: August 26, 2014
    Publication date: December 11, 2014
    Inventors: SHIH-CHANG LEE, MING-LEE CHU, CHIH-HSUN LIN
  • Patent number: 8879268
    Abstract: The present invention discloses a cooling system for an electronic rack, comprising: an electronic rack comprising at least one side wall; at least one electronic chassis comprising a top wall and at least one side wall and disposed inside the electronic rack for housing at least one modular electronics equipment comprising a plurality of electronic components and at least one stationary thermal interface arranged above the plurality of electronic components; a first detachable thermal interface arranged between the top wall of the at least one electronic chassis and the at least one modular electronic equipment; and at least one second detachable thermal interface arranged between the at least one side wall of the electronic rack and the at least one side wall of the at least one electronic chassis.
    Type: Grant
    Filed: February 13, 2012
    Date of Patent: November 4, 2014
    Assignee: Academia Sinica
    Inventors: Shih-Chang Lee, Chi-Hao Jin, Ming-Lee Chu, Chih-Hsun Lin
  • Publication number: 20130256540
    Abstract: The present invention provides a readout device of an accelerator beam monitoring detector, comprising: a transimpedance amplifier receiving a charge signal from a particle detector and converting the charge signal into an analog voltage signal; and a data acquisition system comprising an analog-to-digital converter (ADC) to covert the analog voltage signal into digital data.
    Type: Application
    Filed: March 26, 2013
    Publication date: October 3, 2013
    Applicants: Academia Sinica, National United University, National Central University
    Inventors: PING-KUN TENG, AUGUSTINE EI-FANG CHEN, MING-LEE CHU, CHIH-HSUN LIN, CHUNG-HSIANG WANG
  • Patent number: 8507846
    Abstract: An ion trap mass spectrometer and methods for obtaining a mass spectrum of ions by step scanning the driving frequency in frequency increments over a bandwidth, wherein for each step a specific frequency is held for a fixed number of complete cycles, wherein each specific frequency is changed continuously to the frequency in the next step, and wherein each specific frequency in each step starts at phase zero position.
    Type: Grant
    Filed: August 3, 2012
    Date of Patent: August 13, 2013
    Assignee: Academia Sinica
    Inventors: Chung-Hsuan Chen, Jung-Lee Lin, Ming-Lee Chu
  • Publication number: 20130032709
    Abstract: An ion trap mass spectrometer and methods for obtaining a mass spectrum of ions by step scanning the driving frequency in frequency increments over a bandwidth, wherein for each step a specific frequency is held for a fixed number of complete cycles, wherein each specific frequency is changed continuously to the frequency in the next step, and wherein each specific frequency in each step starts at phase zero position.
    Type: Application
    Filed: August 3, 2012
    Publication date: February 7, 2013
    Applicant: ACADEMIA SINICA
    Inventors: Chung-Hsuan CHEN, Jung-Lee LIN, Ming-Lee CHU
  • Publication number: 20130001415
    Abstract: An ion trap mass spectrometer and methods for obtaining a mass spectrum of ions by scanning an RF frequency applied to the linear ion trap for mass selective ejection of the ions by using two power amplifiers to apply opposite phases of the RF to x and y electrodes.
    Type: Application
    Filed: June 27, 2012
    Publication date: January 3, 2013
    Applicant: ACADEMIA SINICA
    Inventors: Chung-Hsuan CHEN, I-Chung LU, Ming-Lee CHU
  • Publication number: 20120308178
    Abstract: An optical path switching device comprises at least one movable carrier plate; at least two optical fiber connection sockets arranged on the movable carrier plate and each connected with an optical fiber; and a driving device mechanical coupled to the movable carrier plate, driving the movable carrier plate to carry one of the optical fiber connection sockets to a position corresponding to an optical fiber connection plug, whereby the optical fiber connection plug can be coupled to the optical fiber connection socket connecting with an intended optical path. The present invention switches the optical path in a purely-mechanical way without using any optical component. The present invention has advantages of simple structure, low cost and low signal loss.
    Type: Application
    Filed: June 3, 2011
    Publication date: December 6, 2012
    Applicant: RADIANTECH, INC.
    Inventors: MING-LEE CHU, HSI-LIN CHANG
  • Publication number: 20120250259
    Abstract: The present creation discloses a cooling system for an electronic rack, comprising: an electronic rack comprising at least one side wall; at least one electronic chassis comprising a top wall and at least one side wall and disposed inside the electronic rack for housing at least one modular electronics equipment comprising a plurality of electronic components and at least one stationary thermal interface arranged above the plurality of electronic components; a first detachable thermal interface arranged between the top wall of the at least one electronic chassis and the at least one modular electronic equipment; and at least one second detachable thermal interface arranged between the at least one side wall of the electronic rack and the at least one side wall of the at least one electronic chassis.
    Type: Application
    Filed: February 13, 2012
    Publication date: October 4, 2012
    Applicant: Academia Sinica
    Inventors: Shih-Chang Lee, Chi-Hao Jin, Ming-Lee Chu, Chih-Hsun Lin
  • Patent number: 8258464
    Abstract: A mass spectrometer and methods for obtaining the mass spectrum of a single macromolecular or biomolecular ion in a mass spectrometer. The methods include creating single macromolecular or biomolecular primary ions in an ion trap by ionization of a macromolecule or biomolecule; ejecting half of the primary ions for detection with a first charge detector; ejecting half of the primary ions to impact upon a conversion dynode, thereby creating secondary ions for detection with charge amplification detector such as a channeltron or an electromultiplier or an MCP.
    Type: Grant
    Filed: May 24, 2010
    Date of Patent: September 4, 2012
    Assignee: Academia Sinica
    Inventors: Chung-Hsuan Chen, Chien-Hsun Chen, Jung-Lee Lin, Ming-Lee Chu
  • Publication number: 20110284733
    Abstract: A mass spectrometer and methods for obtaining the mass spectrum of a single macromolecular or biomolecular ion in a mass spectrometer. The methods include creating single macromolecular or biomolecular primary ions in an ion trap by ionization of a macromolecule or biomolecule; ejecting half of the primary ions for detection with a first charge detector; ejecting half of the primary ions to impact upon a conversion dynode, thereby creating secondary ions for detection with charge amplification detector such as a channeltron or an electromultiplier or an MCP.
    Type: Application
    Filed: May 24, 2010
    Publication date: November 24, 2011
    Applicant: ACADEMIA SINICA
    Inventors: Chung-Hsuan Chen, Chien-Hsun Chen, Jung-Lee Lin, Ming Lee Chu
  • Publication number: 20110147581
    Abstract: Methods and apparatuses for portable mass spectrometry are disclosed. The apparatuses comprise at least one source of ionized analyte, at least one frequency scanning subsystem, at least one detector, and optionally at least one vacuum pump, and are portable. In some embodiments, the apparatuses comprise multiple sources of ionized analyte and/or are configured to obtain mass spectra of a large analyte, such as analyte with an m/z ratio of at least 105, or analyte with a molecular weight of at least 105 Da, as well as mass spectra of small molecule analyte. In some embodiments, the methods comprise obtaining mass spectra with a portable apparatus described above.
    Type: Application
    Filed: December 22, 2010
    Publication date: June 23, 2011
    Applicant: ACADEMIA SINICA
    Inventors: Chung-Hsuan Chen, Jung-Lee Lin, Ming-Lee Chu