Patents by Inventor Ming-Lee Chu
Ming-Lee Chu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10504713Abstract: An ion trap mass spectrometer and methods for obtaining a mass spectrum of ions by scanning an RF frequency applied to the linear ion trap for mass selective ejection of the ions by using two power amplifiers to apply opposite phases of the RF to x and y electrodes.Type: GrantFiled: February 17, 2016Date of Patent: December 10, 2019Assignee: Academia SinicaInventors: Chung-Hsuan Chen, I-Chung Lu, Ming-Lee Chu
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Patent number: 9915614Abstract: Methods, systems, and devices are disclosed for molecular capture, manipulation, and analysis. In one aspect, a device to aggregate and characterize particles in a fluid includes an electrically insulative substrate including a channel to carry an electrically conducting fluid containing particles, electrodes located in the channel forming a nanoscale opening and including an insulating layer over their surface at the opening, a first circuit to apply a non-uniform ac electric field and a dc bias signal across the electrodes, in which the applied non-uniform ac electric field produces a positive dielectrophoretic force to aggregate the particles in a trapping region including the opening and adjacent region, a second circuit to detect changes in a dc current caused by at least some of the particles in the trapping region, and an optical device that directs a coherent light beam on the opening to determine Raman spectra of the particles in the trapping region.Type: GrantFiled: April 26, 2013Date of Patent: March 13, 2018Assignees: ACADEMIA SINICA, MAX-PLANCK-INSTITUT FUR EISENFORSCHUNG GMBHInventors: Chia-Fu Chou, Lesser-Rojas Leonardo, Ming-Lee Chu, Andreas Erbe
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Patent number: 9696391Abstract: A precision high-speed shuttle device for transporting samples between different positions of a superconducting magnet with different magnetic field strength is provided. The sample equilibrated at the center of the magnet, where the magnetic field is the highest and homogeneous, is shuttled to a higher position above, where the fringe field is lower, for a defined period of time and shuttled back to the center for detection. By shuttling the sample to different positions in the magnet in different experiments one can obtain a field-dependent profile of particular physical parameters. The position and timing of the sample are precisely under the experimental controlled. In this way various magnetic field-dependent nuclear magnetic resonance (NMR) experiments can be conducted in a single high-field NMR spectrometer.Type: GrantFiled: May 6, 2013Date of Patent: July 4, 2017Assignee: ACADEMIA SINICAInventors: Tai-Huang Huang, Ching-Yu Chou, Ming-Lee Chu, Chi-Fon Chang
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Patent number: 9609786Abstract: The present invention discloses a cooling system for an electronic rack, comprising: an electronic rack comprising at least one side wall; at least one electronic chassis comprising a top wall and at least one side wall and disposed inside the electronic rack for housing at least one modular electronics equipment comprising a plurality of electronic components and at least one stationary thermal interface arranged above the plurality of electronic components; a first detachable thermal interface arranged between the top wall of the at least one electronic chassis and the at least one modular electronic equipment; and at least one second detachable thermal interface arranged between the at least one side wall of the electronic rack and the at least one side wall of the at least one electronic chassis.Type: GrantFiled: August 26, 2014Date of Patent: March 28, 2017Assignee: ACADEMIA SINICAInventors: Shih-Chang Lee, Ming-Lee Chu, Chih-Hsun Lin
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Publication number: 20160163529Abstract: An ion trap mass spectrometer and methods for obtaining a mass spectrum of ions by scanning an RF frequency applied to the linear ion trap for mass selective ejection of the ions by using two power amplifiers to apply opposite phases of the RF to x and y electrodes.Type: ApplicationFiled: February 17, 2016Publication date: June 9, 2016Inventors: Chung-Hsuan CHEN, I-Chung LU, Ming-Lee CHU
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Patent number: 9285486Abstract: The invention relates to a method for radiation detection signal processing, and more particularly to a method capable of using a periodic signal to control the time of charging/discharging to a capacitor of an integrator. The method can be used for detecting the energy of incident photon of Gamma ray during the happening of an event while reducing dead time, and thereby, the count rate is increased. As the periodic signal is used as the signal for controlling the time of charging/discharging to a capacitor, the charging/discharging time of the integrator is no longer being controlled by the triggering time of the event, and thus, the present method is advantageous in that: the control method and circuit architecture are comparatively simpler since the charging/discharging time of the integrator no longer required to be controlled precisely, and thus the integration error due to insufficient resolution in delay element can be avoided.Type: GrantFiled: October 20, 2014Date of Patent: March 15, 2016Assignee: INSTITUTE OF NUCLEAR ENERGY RESEARCH ATOMIC ENERGY COUNCIL, EXECUTIVE YUANInventors: Sheng-Pin Tseng, Ming-Lee Chu, Meei-Ling Jan
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Patent number: 9224586Abstract: Methods and apparatuses for portable mass spectrometry are disclosed. The apparatuses comprise at least one source of ionized analyte, at least one frequency scanning subsystem, at least one detector, and optionally at least one vacuum pump, and are portable. In some embodiments, the apparatuses comprise multiple sources of ionized analyte and/or are configured to obtain mass spectra of a large analyte, such as analyte with an m/z ratio of at least 105, or analyte with a molecular weight of at least 105 Da, as well as mass spectra of small molecule analyte. In some embodiments, the methods comprise obtaining mass spectra with a portable apparatus described above.Type: GrantFiled: December 22, 2010Date of Patent: December 29, 2015Assignee: Academia SinicaInventors: Chung-Hsuan Chen, Jung-Lee Lin, Ming-Lee Chu
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Publication number: 20150115167Abstract: The invention relates to a method for radiation detection signal processing, and more particularly to a method capable of using a periodic signal to control the time of charging/discharging to a capacitor of an integrator. The method can be used for detecting the energy of incident photon of Gamma ray during the happening of an event while reducing dead time, and thereby, the count rate is increased. As the periodic signal is used as the signal for controlling the time of charging/discharging to a capacitor, the charging/discharging time of the integrator is no longer being controlled by the triggering time of the event, and thus, the present method is advantageous in that: the control method and circuit architecture are comparatively simpler since the charging/discharging time of the integrator no longer required to be controlled precisely, and thus the integration error due to insufficient resolution in delay element can be avoided.Type: ApplicationFiled: October 20, 2014Publication date: April 30, 2015Inventors: SHENG-PIN TSENG, MING-LEE CHU, MEEI-LING JAN
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Patent number: 8963075Abstract: A novel system and method for charge-monitoring mass spectrometry is provided. The mass spectrometer can be used to measure the mass of one or more analytes having masses in the range of about a few Daltons to more than about 1015 Daltons. The invention can be used for rapid mass distribution measurements. For example, the system and method can be used to distinguish cancer cells from normal cells when their mass distributions are different.Type: GrantFiled: December 11, 2008Date of Patent: February 24, 2015Assignee: Academia SinicaInventors: Chung Hsuan Chen, Wen-Ping Peng, Ming Lee Chu, Huan Cheng Chang, Huan-Chang Lin
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Publication number: 20140362531Abstract: The present invention discloses a cooling system for an electronic rack, comprising: an electronic rack comprising at least one side wall; at least one electronic chassis comprising a top wall and at least one side wall and disposed inside the electronic rack for housing at least one modular electronics equipment comprising a plurality of electronic components and at least one stationary thermal interface arranged above the plurality of electronic components; a first detachable thermal interface arranged between the top wall of the at least one electronic chassis and the at least one modular electronic equipment; and at least one second detachable thermal interface arranged between the at least one side wall of the electronic rack and the at least one side wall of the at least one electronic chassis.Type: ApplicationFiled: August 26, 2014Publication date: December 11, 2014Inventors: SHIH-CHANG LEE, MING-LEE CHU, CHIH-HSUN LIN
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Patent number: 8879268Abstract: The present invention discloses a cooling system for an electronic rack, comprising: an electronic rack comprising at least one side wall; at least one electronic chassis comprising a top wall and at least one side wall and disposed inside the electronic rack for housing at least one modular electronics equipment comprising a plurality of electronic components and at least one stationary thermal interface arranged above the plurality of electronic components; a first detachable thermal interface arranged between the top wall of the at least one electronic chassis and the at least one modular electronic equipment; and at least one second detachable thermal interface arranged between the at least one side wall of the electronic rack and the at least one side wall of the at least one electronic chassis.Type: GrantFiled: February 13, 2012Date of Patent: November 4, 2014Assignee: Academia SinicaInventors: Shih-Chang Lee, Chi-Hao Jin, Ming-Lee Chu, Chih-Hsun Lin
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Publication number: 20130256540Abstract: The present invention provides a readout device of an accelerator beam monitoring detector, comprising: a transimpedance amplifier receiving a charge signal from a particle detector and converting the charge signal into an analog voltage signal; and a data acquisition system comprising an analog-to-digital converter (ADC) to covert the analog voltage signal into digital data.Type: ApplicationFiled: March 26, 2013Publication date: October 3, 2013Applicants: Academia Sinica, National United University, National Central UniversityInventors: PING-KUN TENG, AUGUSTINE EI-FANG CHEN, MING-LEE CHU, CHIH-HSUN LIN, CHUNG-HSIANG WANG
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Patent number: 8507846Abstract: An ion trap mass spectrometer and methods for obtaining a mass spectrum of ions by step scanning the driving frequency in frequency increments over a bandwidth, wherein for each step a specific frequency is held for a fixed number of complete cycles, wherein each specific frequency is changed continuously to the frequency in the next step, and wherein each specific frequency in each step starts at phase zero position.Type: GrantFiled: August 3, 2012Date of Patent: August 13, 2013Assignee: Academia SinicaInventors: Chung-Hsuan Chen, Jung-Lee Lin, Ming-Lee Chu
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Publication number: 20130032709Abstract: An ion trap mass spectrometer and methods for obtaining a mass spectrum of ions by step scanning the driving frequency in frequency increments over a bandwidth, wherein for each step a specific frequency is held for a fixed number of complete cycles, wherein each specific frequency is changed continuously to the frequency in the next step, and wherein each specific frequency in each step starts at phase zero position.Type: ApplicationFiled: August 3, 2012Publication date: February 7, 2013Applicant: ACADEMIA SINICAInventors: Chung-Hsuan CHEN, Jung-Lee LIN, Ming-Lee CHU
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Publication number: 20130001415Abstract: An ion trap mass spectrometer and methods for obtaining a mass spectrum of ions by scanning an RF frequency applied to the linear ion trap for mass selective ejection of the ions by using two power amplifiers to apply opposite phases of the RF to x and y electrodes.Type: ApplicationFiled: June 27, 2012Publication date: January 3, 2013Applicant: ACADEMIA SINICAInventors: Chung-Hsuan CHEN, I-Chung LU, Ming-Lee CHU
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Publication number: 20120308178Abstract: An optical path switching device comprises at least one movable carrier plate; at least two optical fiber connection sockets arranged on the movable carrier plate and each connected with an optical fiber; and a driving device mechanical coupled to the movable carrier plate, driving the movable carrier plate to carry one of the optical fiber connection sockets to a position corresponding to an optical fiber connection plug, whereby the optical fiber connection plug can be coupled to the optical fiber connection socket connecting with an intended optical path. The present invention switches the optical path in a purely-mechanical way without using any optical component. The present invention has advantages of simple structure, low cost and low signal loss.Type: ApplicationFiled: June 3, 2011Publication date: December 6, 2012Applicant: RADIANTECH, INC.Inventors: MING-LEE CHU, HSI-LIN CHANG
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Publication number: 20120250259Abstract: The present creation discloses a cooling system for an electronic rack, comprising: an electronic rack comprising at least one side wall; at least one electronic chassis comprising a top wall and at least one side wall and disposed inside the electronic rack for housing at least one modular electronics equipment comprising a plurality of electronic components and at least one stationary thermal interface arranged above the plurality of electronic components; a first detachable thermal interface arranged between the top wall of the at least one electronic chassis and the at least one modular electronic equipment; and at least one second detachable thermal interface arranged between the at least one side wall of the electronic rack and the at least one side wall of the at least one electronic chassis.Type: ApplicationFiled: February 13, 2012Publication date: October 4, 2012Applicant: Academia SinicaInventors: Shih-Chang Lee, Chi-Hao Jin, Ming-Lee Chu, Chih-Hsun Lin
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Patent number: 8258464Abstract: A mass spectrometer and methods for obtaining the mass spectrum of a single macromolecular or biomolecular ion in a mass spectrometer. The methods include creating single macromolecular or biomolecular primary ions in an ion trap by ionization of a macromolecule or biomolecule; ejecting half of the primary ions for detection with a first charge detector; ejecting half of the primary ions to impact upon a conversion dynode, thereby creating secondary ions for detection with charge amplification detector such as a channeltron or an electromultiplier or an MCP.Type: GrantFiled: May 24, 2010Date of Patent: September 4, 2012Assignee: Academia SinicaInventors: Chung-Hsuan Chen, Chien-Hsun Chen, Jung-Lee Lin, Ming-Lee Chu
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Publication number: 20110284733Abstract: A mass spectrometer and methods for obtaining the mass spectrum of a single macromolecular or biomolecular ion in a mass spectrometer. The methods include creating single macromolecular or biomolecular primary ions in an ion trap by ionization of a macromolecule or biomolecule; ejecting half of the primary ions for detection with a first charge detector; ejecting half of the primary ions to impact upon a conversion dynode, thereby creating secondary ions for detection with charge amplification detector such as a channeltron or an electromultiplier or an MCP.Type: ApplicationFiled: May 24, 2010Publication date: November 24, 2011Applicant: ACADEMIA SINICAInventors: Chung-Hsuan Chen, Chien-Hsun Chen, Jung-Lee Lin, Ming Lee Chu
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Publication number: 20110147581Abstract: Methods and apparatuses for portable mass spectrometry are disclosed. The apparatuses comprise at least one source of ionized analyte, at least one frequency scanning subsystem, at least one detector, and optionally at least one vacuum pump, and are portable. In some embodiments, the apparatuses comprise multiple sources of ionized analyte and/or are configured to obtain mass spectra of a large analyte, such as analyte with an m/z ratio of at least 105, or analyte with a molecular weight of at least 105 Da, as well as mass spectra of small molecule analyte. In some embodiments, the methods comprise obtaining mass spectra with a portable apparatus described above.Type: ApplicationFiled: December 22, 2010Publication date: June 23, 2011Applicant: ACADEMIA SINICAInventors: Chung-Hsuan Chen, Jung-Lee Lin, Ming-Lee Chu