Abstract: Provided are a CD80 protein variant and a fusion protein comprising the CD80 protein variant, which can bind to PD-L1, CTLA-4 and CD28, activate the activity of T lymphocytes, and inhibit the growth and/or proliferation of tumors or tumor cells. Also provided are a nucleic acid encoding the fusion protein, a vector comprising the fusion protein, a cell comprising the nucleic acid or the vector, a method for preparing the fusion protein, and use of the fusion protein.

Abstract: An electric valve includes a valve seat component, and a valve core component. The valve seat component includes a valve seat and a sealing ring. The valve core component includes a valve core. The valve core includes a lower section, and the lower section is annular. The valve seat component further includes an inner bushing and a pressure block. The valve seat includes an axial through hole, and at least part of the inner bushing is arranged in the axial through hole. The sealing ring is arranged between an outer side of the inner bushing and the valve seat. The valve seat includes a first stepped portion, and a lower end surface of the pressure block is abutted against the first stepped portion and/or the sealing ring.

Abstract: A receiving structure providing real-time information as to the materials constituting its contents includes a box body, a first side plate, and a second side plate. The box body, the first side plate, and the second side plate forming a receiving space, and the receiving space receives materials. A discharge port is formed between the second side plate and the first side plate, the discharge port is in communication with the receiving space, and the discharge port is configured to take out the material. A material checking unit is provided on the first side plate, the material checking unit detects and enables real time identification of the materials in the receiving structure.

Abstract: An electric valve includes a valve body component, a valve seat component, and a valve core component. The valve core component comprises a valve core. The valve core includes a body portion and a lower section, and the lower section is annular. A transition portion is included between the body portion and the lower section. The transition portion includes a first transition section connected with the lower section. An outer diameter of an upper end of the first transition section is greater than an outer diameter of a lower end of the first transition section.

Abstract: An information processing method and apparatus, an electronic device, and a storage medium. The information processing method provided by the present disclosure includes: displaying an adjustment interface of an organizational structure on a display interface in response to a first operation event, a pattern of an organization department in the organizational structure being displayed in the adjustment interface, and the pattern being displayed according to a hierarchical relationship of the organization department; in response to a second operation event based on the pattern, generating a first processing item for adjusting the organizational structure; and triggering a processing flow of the first processing item in response to a third operation event.

Abstract: Provided is a SIRP? variant and a fusion protein thereof, capable of specifically blocking interaction between CD47 protein and SIRP?, not causing coagulation reaction, and capable of inhibiting growth and/or proliferation of tumors or tumor cells.

Abstract: The present application relates to a bifunctional fusion protein, which includes a first binding domain that specifically binds to CLDN18.2, and a second binding domain that specifically binds to a CD47 protein, wherein the second binding domain has at least one of the following characteristics: (a) binding to a CD47 protein at 4×10?8M or a lower KD value; (b) specifically blocking the interaction between CD47 protein and SIRP?; (c) not causing a coagulation reaction; and (d) inhibiting the growth and/or proliferation of a tumor or tumor cells.

Abstract: An electric valve includes a valve seat component, a valve body component, and a valve core component. The valve core component includes a sealing portion. The valve core component is arranged in a valve chamber of the electric valve, and the valve core component includes a valve core body. The valve core body is substantially tubular, the valve core body has an integral structure, and the valve core body includes an annular thin-walled portion to abut against the sealing portion of the valve seat component. The thickness of the annular thin-walled portion is M, and 0.3 mm?M?2.0 mm.

Abstract: A valve core assembly includes a transmission component and a valve core component. The valve core component includes a valve core body and a lower stop component, and the valve core body is substantially tubular. The lower stop component is provided in an inner chamber of the valve core body and is fixedly connected to the valve core body. The lower stop component includes a lower stop portion. An upper chamber is located above the lower stop portion, and a lower chamber is located below the lower stop portion. The lower stop component includes a first axial through hole communicating with the upper chamber and the lower chamber.

Abstract: A bispecific fusion protein may include a first binding domain and a second binding domain. The first binding domain may include an antibody specifically binding to PD-L1, the antibody may include two antibody light chains and two antibody heavy chains, and the antibody light chains and the antibody heavy chains may be linked by disulfide bonds. The second binding domain may include an Ig-like domain of VEGFR1 and an Ig-like domain of VEGFR2. The N-terminus of the Ig-like domain of VEGFR1 or the N-terminus of the Ig-like domain of VEGFR2 may be directly or indirectly linked to the C-terminus of the antibody heavy chains, separately. A pharmaceutical composition may include the bispecific fusion protein. Such a bispecific fusion protein may be pharmaceutically used and may effectively and safely kill tumor cells.

Abstract: The present disclosure relates to the technical field of autonomous underwater vehicles, in particular to an unmanned cable-free operation type autonomous underwater vehicle. The unmanned cable-free operation type autonomous underwater vehicle includes a bow, a middle and a stern, each of the bow, the middle and the stern is of a hollow structure, the middle is provided with a manipulator lifting device and a cabin door opening and closing mechanism, the bow is provided with a first horizontal channel propeller and a first vertical channel propeller, and the stern is provided with two second vertical channel propellers and four main propellers. High-speed cruising of the unmanned cable-free operation type autonomous underwater vehicle can be achieved, and stable and precise hovering needed by the operation of the unmanned cable-free operation type autonomous underwater vehicle can also be achieved.

Abstract: Provided is an antibody or an antigen-binding fragment thereof, having one or more properties selected from the group consisting of: 1) being capable of binding to an AXL protein by a KD value of 1×10?8 M or lower; 2) being capable of specifically recognizing an AXL protein expressed on a cell surface; and 3) being capable of mediating internalization after binding to the AXL protein expressed on the cell surface. The antibody may further used for constructing an immunoconjugate. The antibody and the immunoconjugate may inhibit the proliferation of tumor cells.

Abstract: An electric valve includes a valve seat component, and a valve core component. The valve seat component includes a valve seat and a sealing ring. The valve core component includes a valve core. The valve core includes a lower section, and the lower section is annular. The valve seat component further includes an inner bushing and a pressure block. The valve seat includes an axial through hole, and at least part of the inner bushing is arranged in the axial through hole. The sealing ring is arranged between an outer side of the inner bushing and the valve seat. The valve seat includes a first stepped portion, and a lower end surface of the pressure block is abutted against the first stepped portion and/or the sealing ring.

Abstract: An electric valve includes a valve body component, a valve seat component, and a valve core component. The valve core component comprises a valve core. The valve core includes a body portion and a lower section, and the lower section is annular. A transition portion is included between the body portion and the lower section. The transition portion includes a first transition section connected with the lower section. An outer diameter of an upper end of the first transition section is greater than an outer diameter of a lower end of the first transition section.

Abstract: Provided by the present invention are a fusion protein binding to a CD47 protein and an application thereof, wherein the fusion protein is capable of binding to a CD47 protein by using a KD value of 1×10?8M or lower. The fusion protein may specifically block the interaction between a CD47 protein and SIRP? without causing a blood coagulation reaction, and may further inhibit the growth and/or proliferation of tumors or tumor cells.

Abstract: A valve core assembly includes a transmission component and a valve core component. The valve core component includes a valve core body and a lower stop component, and the valve core body is substantially tubular. The lower stop component is provided in an inner chamber of the valve core body and is fixedly connected to the valve core body. The lower stop component includes a lower stop portion. An upper chamber is located above the lower stop portion, and a lower chamber is located below the lower stop portion. The lower stop component includes a first axial through hole communicating with the upper chamber and the lower chamber.

Abstract: An electric valve includes a valve seat component, a valve body component, and a valve core component. The valve core component includes a sealing portion. The valve core component is arranged in a valve chamber of the electric valve, and the valve core component includes a valve core body. The valve core body is substantially tubular, the valve core body has an integral structure, and the valve core body includes an annular thin-walled portion to abut against the sealing portion of the valve seat component. The thickness of the annular thin-walled portion is M, and 0.3 mm?M?2.0 mm.

Abstract: An electric valve, including a valve body part, a valve seat part, and a valve core part. The valve core part is provided in an inner cavity of the valve body part. The valve core part comprises a valve core. The valve core comprises a lower segment portion. The valve base part comprises a first sealing portion. An end of the lower segment portion can be abutted against or separated from the first sealing portion. The valve body part comprises a bushing part. The valve core part comprises a second sealing portion. The diameter D1 of the axial projection loop of the outer edge of the second sealing portion on the cross section of the lower segment portion, the outer diameter D2 of the lower segment portion, and the inner diameter D3 of the lower segment portion, satisfy: 0.2 mm2?D1*(D2?D3)?6 mm2.