Abstract: The present application relates to a bifunctional fusion protein, which includes a first binding domain that specifically binds to CLDN18.2, and a second binding domain that specifically binds to a CD47 protein, wherein the second binding domain has at least one of the following characteristics: (a) binding to a CD47 protein at 4×10?8M or a lower KD value; (b) specifically blocking the interaction between CD47 protein and SIRP?; (c) not causing a coagulation reaction; and (d) inhibiting the growth and/or proliferation of a tumor or tumor cells.

Abstract: An electric valve includes a valve seat component, a valve body component, and a valve core component. The valve core component includes a sealing portion. The valve core component is arranged in a valve chamber of the electric valve, and the valve core component includes a valve core body. The valve core body is substantially tubular, the valve core body has an integral structure, and the valve core body includes an annular thin-walled portion to abut against the sealing portion of the valve seat component. The thickness of the annular thin-walled portion is M, and 0.3 mm?M?2.0 mm.

Abstract: A valve core assembly includes a transmission component and a valve core component. The valve core component includes a valve core body and a lower stop component, and the valve core body is substantially tubular. The lower stop component is provided in an inner chamber of the valve core body and is fixedly connected to the valve core body. The lower stop component includes a lower stop portion. An upper chamber is located above the lower stop portion, and a lower chamber is located below the lower stop portion. The lower stop component includes a first axial through hole communicating with the upper chamber and the lower chamber.

Abstract: A bispecific fusion protein may include a first binding domain and a second binding domain. The first binding domain may include an antibody specifically binding to PD-L1, the antibody may include two antibody light chains and two antibody heavy chains, and the antibody light chains and the antibody heavy chains may be linked by disulfide bonds. The second binding domain may include an Ig-like domain of VEGFR1 and an Ig-like domain of VEGFR2. The N-terminus of the Ig-like domain of VEGFR1 or the N-terminus of the Ig-like domain of VEGFR2 may be directly or indirectly linked to the C-terminus of the antibody heavy chains, separately. A pharmaceutical composition may include the bispecific fusion protein. Such a bispecific fusion protein may be pharmaceutically used and may effectively and safely kill tumor cells.

Abstract: The present disclosure relates to the technical field of autonomous underwater vehicles, in particular to an unmanned cable-free operation type autonomous underwater vehicle. The unmanned cable-free operation type autonomous underwater vehicle includes a bow, a middle and a stern, each of the bow, the middle and the stern is of a hollow structure, the middle is provided with a manipulator lifting device and a cabin door opening and closing mechanism, the bow is provided with a first horizontal channel propeller and a first vertical channel propeller, and the stern is provided with two second vertical channel propellers and four main propellers. High-speed cruising of the unmanned cable-free operation type autonomous underwater vehicle can be achieved, and stable and precise hovering needed by the operation of the unmanned cable-free operation type autonomous underwater vehicle can also be achieved.

Abstract: Provided is an antibody or an antigen-binding fragment thereof, having one or more properties selected from the group consisting of: 1) being capable of binding to an AXL protein by a KD value of 1×10?8 M or lower; 2) being capable of specifically recognizing an AXL protein expressed on a cell surface; and 3) being capable of mediating internalization after binding to the AXL protein expressed on the cell surface. The antibody may further used for constructing an immunoconjugate. The antibody and the immunoconjugate may inhibit the proliferation of tumor cells.

Abstract: An electric valve includes a valve seat component, and a valve core component. The valve seat component includes a valve seat and a sealing ring. The valve core component includes a valve core. The valve core includes a lower section, and the lower section is annular. The valve seat component further includes an inner bushing and a pressure block. The valve seat includes an axial through hole, and at least part of the inner bushing is arranged in the axial through hole. The sealing ring is arranged between an outer side of the inner bushing and the valve seat. The valve seat includes a first stepped portion, and a lower end surface of the pressure block is abutted against the first stepped portion and/or the sealing ring.

Abstract: An electric valve includes a valve body component, a valve seat component, and a valve core component. The valve core component comprises a valve core. The valve core includes a body portion and a lower section, and the lower section is annular. A transition portion is included between the body portion and the lower section. The transition portion includes a first transition section connected with the lower section. An outer diameter of an upper end of the first transition section is greater than an outer diameter of a lower end of the first transition section.

Abstract: Provided by the present invention are a fusion protein binding to a CD47 protein and an application thereof, wherein the fusion protein is capable of binding to a CD47 protein by using a KD value of 1×10?8M or lower. The fusion protein may specifically block the interaction between a CD47 protein and SIRP? without causing a blood coagulation reaction, and may further inhibit the growth and/or proliferation of tumors or tumor cells.

Abstract: An electric valve includes a valve seat component, a valve body component, and a valve core component. The valve core component includes a sealing portion. The valve core component is arranged in a valve chamber of the electric valve, and the valve core component includes a valve core body. The valve core body is substantially tubular, the valve core body has an integral structure, and the valve core body includes an annular thin-walled portion to abut against the sealing portion of the valve seat component. The thickness of the annular thin-walled portion is M, and 0.3 mm?M?2.0 mm.

Abstract: A valve core assembly includes a transmission component and a valve core component. The valve core component includes a valve core body and a lower stop component, and the valve core body is substantially tubular. The lower stop component is provided in an inner chamber of the valve core body and is fixedly connected to the valve core body. The lower stop component includes a lower stop portion. An upper chamber is located above the lower stop portion, and a lower chamber is located below the lower stop portion. The lower stop component includes a first axial through hole communicating with the upper chamber and the lower chamber.

Abstract: An electric valve, including a valve body part, a valve seat part, and a valve core part. The valve core part is provided in an inner cavity of the valve body part. The valve core part comprises a valve core. The valve core comprises a lower segment portion. The valve base part comprises a first sealing portion. An end of the lower segment portion can be abutted against or separated from the first sealing portion. The valve body part comprises a bushing part. The valve core part comprises a second sealing portion. The diameter D1 of the axial projection loop of the outer edge of the second sealing portion on the cross section of the lower segment portion, the outer diameter D2 of the lower segment portion, and the inner diameter D3 of the lower segment portion, satisfy: 0.2 mm2?D1*(D2?D3)?6 mm2.

Abstract: A heating body for an electronic vaporization device having an aerosol-generation substrate is disclosed. The heating body comprises a dense substrate comprising a liquid absorbing surface and a vaporization surface arranged opposite to each other. The dense substrate further comprises a plurality of micropores arranged through the liquid absorbing surface and the vaporization surface. The vaporization surface is a wetting structure that is surface treated. The wetting structure is in communication with the plurality of micropores in a liquid guiding manner.

Abstract: A heating body for an electronic vaporization is disclosed. The heating body comprises a liquid guiding substrate, a heating material layer, a first protective film, and a second protective film. The liquid guiding substrates comprises a heating region and an electrode region. The heating material layer is arranged on a first surface of the liquid guiding substrate. The first protective film is made of a non-conductive material resistant to a corrosion of an aerosol-generation substrate. The second protective film is made of a conductive material resistant to a corrosion of the aerosol-generation substrate.

Abstract: An electric valve and manufacturing method therefor, the electric valve including a valve body part, a valve seat part, a transmission part and a valve core part, wherein the valve core part includes a valve core body and a lower stop part; the valve core body is essentially tubular, and the valve core body is of an integrated structure and includes an annular thin wall portion; the lower stop part is arranged in an inner cavity of the valve core body, and the lower stop part comprises a lower stop portion; an upper cavity is present above the lower stop portion, a lower cavity is present below the lower stop portion, and the lower stop part includes a first axial through hole which is in communication with the upper cavity and the lower cavity.

Abstract: A VEGF inhibitor is used in preparation of a medicament for treating hypoxia-related diseases. The VEGF inhibitor can significantly inhibit VEGF stress expression caused by hypoxia by acting on a binding pathway of VEGF and a VEGF receptor, is used for treating hypoxia and other related diseases, can significantly improve the oxygenation index of a patient, and can alleviate the hypoxic state of lung and other organ tissues, having good therapeutic effects.

Abstract: A sandwich-structured dielectric material for pulse energy storage is provided as well as a preparation method thereof. Employing a sandwich structure and combining the properties of ceramic-glass materials prepares a high performance dielectric material for pulse energy storage, in which the ceramic dielectric is core-shell structured powder of BaxSr1-xTiO3 coated with SiO2, and the glass material is alkali-free glass AF45, of which the chemical composition is 63% SiO2-12% BaO-16% B2O3-9% Al2O3. AF45 alkali-free glass paste is spin-coated on both sides of the ceramic and calcined to get a layer-structured material of glass-ceramic-glass.

Abstract: Provided by the invention is an antibody or an antigen-binding fragment thereof, which binds to a CD38 protein at a KD value below 1×10?9M. The antibody or an antigen-binding fragment thereof has strong specific recognition and binding capabilities for CD38 protein, and may kill CD38+ cells by means of antibody-dependent cell-mediated cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC) and/or apoptosis. Further provided by the present invention is an application of the antibody or antigen-binding fragment thereof in preventing and treating tumors.