Abstract: A compound represented by general formula (I) or a stereoisomer, tautomer, deuterated substance, solvate, prodrug, metabolite, pharmaceutically acceptable salt or co-crystal thereof, an intermediate thereof and a preparation method therefor, as well as an application in preparation of a drug for treating diabetes.

Abstract: Disclosed are a super-resolution imaging system (1, 41, 51), a super-resolution imaging method, a biological sample identification system (4, 61) and method, a nucleic acid sequencing imaging system (5) and method, and a nucleic acid identification system (6) and method. The super-resolution imaging system (1, 41, 51) includes an illumination system (A) and an imaging system (B). The illumination system (A) outputs excitation light to irradiate a biological sample to generate excited light, and the imaging system (B) collects and records the excited light to generate an excited light image. The illumination system (A) includes an excitation light source (10, 10a) and a structured light generation and modulation device (11, 11a). The excitation light source (10, 10a) outputs the excitation light, and the structured light generation and modulation device (11, 11a) modulates the excitation light into structured light to irradiate the biological sample to generate the excited light.

Abstract: A wavelength conversion element including a substrate, a blocking wall structure layer, and a wavelength conversion layer is provided. The blocking wall structure layer is disposed on a surface of the substrate and defines multiple microgrooves. Reflectivity of the blocking wall structure layer is in a range of 1% to 99%. The wavelength conversion layer is disposed in the microgrooves and includes multiple wavelength conversion particles. A height of the blocking wall structure layer along a normal direction of the surface of the substrate is greater than a height of the wavelength conversion layer along the normal direction of the surface of the substrate. A backlight module adopting the wavelength conversion element is also provided.

Abstract: A gene sequencing reaction device, a gene sequencing system and a gene sequencing reaction method. The gene sequencing reaction device includes: a supporting platform; a dipping container disposed on the supporting platform, wherein the dipping container has a dipping reaction area, and the dipping reaction area is configured to hold a chemical reagent for gene sequencing reaction, so as to dip a sequencing chip having a DNA sample loading structure on the surface and having a DNA sample loaded thereon in the chemical reagent to perform a gene sequencing reaction; a temperature control apparatus, configured to control the temperature of the chemical reagent in the dipping reaction area; and a transfer apparatus, configured to insert the sequencing chip into the dipping reaction area or pull out the sequencing chip from the dipping reaction area.

Abstract: Examples of the present disclosure describe systems and methods for generating multiple semantic hypotheses for search query intent understanding. In aspects, a search query may be received by a query analysis component associated with a search system. The query analysis component may be used to evaluate the search query for ambiguity in the domain, intent, and/or slot(s) of the search query. A set of hypotheses representing for one or more combinations of the domain, intent, and/or slot(s) of the search query may be generated. The set of hypotheses may be scored and/or ranked. Based on the scores/ranks, one or more of the hypotheses in the set of hypotheses may be provided to a user and/or one or more processing components accessible to the search system.

Abstract: An article support device has a pair of support platforms arranged symmetrically and opposite to each other. Each of the support platforms includes a support frame, a support plate disposed on a top of the support frame and having a horizontal support top surface, and at least one positioning block installed on the horizontal support top surface. The horizontal support top surfaces of the support plates are located at a same height position. The article is supported on the horizontal support top surfaces and positioned between the positioning blocks on the support plates. An accommodation space is defined between the support plates and the support frames, and an automated guided vehicle moves into the accommodation space. An article carried on the article support device is loadable onto the automatic guided vehicle or the article carried on the automatic guided vehicle is unloadable onto the article support device.

Abstract: A gene sequencing reaction device, a gene sequencing system and a gene sequencing reaction method. The gene sequencing reaction device includes: a supporting platform; a dipping container disposed on the supporting platform, wherein the dipping container has a dipping reaction area, and the dipping reaction area is configured to hold a chemical reagent for gene sequencing reaction, so as to dip a sequencing chip having a DNA sample loading structure on the surface and having a DNA sample loaded thereon in the chemical reagent to perform a gene sequencing reaction; a temperature control apparatus, configured to control the temperature of the chemical reagent in the dipping reaction area; and a transfer apparatus, configured to insert the sequencing chip into the dipping reaction area or pull out the sequencing chip from the dipping reaction area.

Abstract: A system comprising one or more processors and one or more non-transitory computer-readable media storing computing instructions that, when executed on the one or more processors, cause the one or more processors to perform operations comprising: generating a schedule summary comprising one or more selectable portions of availability for drivers; receiving a selection of an unfilled portion of a respective schedule for a respective driver of the drivers adds the respective driver to a list of respective drivers to be scheduled on the schedule summary displayed on a GUI of an electronic device of a user; receiving one or more selections of the one or more selectable portions of availability of the schedule summary causes one or more changes to occur on the schedule summary displayed on the GUI of the electronic device of the user; and displaying one or more schedules for the drivers. Other embodiments are disclosed herein.

Abstract: The present invention provides a method for sequencing a nucleic acid using an immersion reaction protocol. The immersion reaction protocol comprises sequentially immersing a solid support having nucleic acid molecules immobilized thereon in different reaction containers to realize nucleic acid sequencing. FIG.

Abstract: The present invention provides a method for sequencing a nucleic acid using an immersion reaction protocol. The immersion reaction protocol comprises sequentially immersing a solid support having nucleic acid molecules immobilized thereon in different reaction containers to realize nucleic acid sequencing.

Abstract: Systems and methods including one or more processors and one or more non-transitory storage devices storing computing instructions configured to run on the one or more processors and perform: receiving a request to generate one or more schedules for one or more drivers; determining one or more respective day cab schedules for each respective day cab driver of the one or more drivers; assigning one or more permanent drivers of the one or more drivers to one or more permanent tractors; assigning at least one driver of one or more remaining drivers of the one or more drivers to at least one tractor using a first set of rules; generating the one or more schedules for the one or more drivers; and coordinating displaying the one or more schedules for the one or more drivers on an electronic device of a user. Other embodiments are disclosed herein.

Abstract: A system including one or more processors and one or more non-transitory computer-readable media storing computing instructions that, when executed on the one or more processors, cause the one or more processors to perform: receiving multiple purchase orders for delivery of items from vendors to distribution centers of a distribution network over a period of time, wherein each of the multiple purchase orders specifies a respective vendor of the vendors and a respective distribution center of the distribution centers; generating partitions of the distribution network; generating respective candidate load routes for fulfilling the purchase orders for each of the partitions in parallel using a multi-threaded column generation engine; and selecting final load routes from the respective candidate load routes. Other embodiments are disclosed.

Abstract: The present invention provides a method for sequencing a nucleic acid using an immersion reaction protocol. The immersion reaction protocol comprises sequentially immersing a solid support having nucleic acid molecules immobilized thereon in different reaction containers to realize nucleic acid sequencing.

Abstract: Provided are a method for detecting spatial information of nucleic acids in a sample, as well as a nucleic acid array used in the method and a method for producing the nucleic acid array.

Abstract: A liquid crystal display device includes a first substrate; a second substrate; and a vertical alignment-type liquid crystal layer. The first substrate includes a backplane circuit, a first interlayer insulating layer covering the backplane circuit, a first reflective electrode provided on the first interlayer insulating layer and including a first region located in each of pixels and a second region located between any two adjacent pixels, a second interlayer insulating layer covering the first reflective electrode, and a pixel electrode provided on the second interlayer insulating layer in each pixel. The pixel electrode is electrically connected with the backplane circuit in first and second contact holes formed in the first and second interlayer insulating layers. The first substrate further includes a second reflective electrode provided on the second interlayer insulating layer so as to overlap the first contact hole as seen in a direction normal to a display surface.

Abstract: A liquid crystal display device includes a first substrate; a second substrate; and a vertical alignment-type liquid crystal layer. The first substrate includes a backplane circuit, a first interlayer insulating layer covering the backplane circuit, a first reflective electrode provided on the first interlayer insulating layer and including a first region located in each of pixels and a second region located between any two adjacent pixels, a second interlayer insulating layer covering the first reflective electrode, and a pixel electrode provided on the second interlayer insulating layer in each pixel. The pixel electrode is electrically connected with the backplane circuit in first and second contact holes formed in the first and second interlayer insulating layers. The first substrate further includes a second reflective electrode provided on the second interlayer insulating layer so as to overlap the first contact hole as seen in a direction normal to a display surface.

Abstract: A liquid crystal display device includes a first substrate, a second substrate, a liquid crystal layer, and a plurality of pixels. Each of the pixels has a reflection region for performing display in a reflective mode. The first substrate includes a pixel electrode provided in each of the pixels and a reflection layer positioned opposite to the liquid crystal layer with respect to the pixel electrode. The reflection layer has a first region positioned in each of the pixels and a second region positioned between any two pixels adjacent to each other. Voltages of an identical polarity are applied to the liquid crystal layer for any two pixels adjacent to each other in a row direction, for any two pixels adjacent to each other in a column direction, or for all the pixels.

Abstract: The application provides a chemically modified recognizable biochip, method of preparation and use thereof.

Abstract: A liquid crystal display device includes a first substrate, a second substrate, a vertical alignment liquid crystal layer, and a plurality of pixels. Each of the pixels includes a reflective region for performing display in a reflection mode. The first substrate includes a reflective electrode including a first region located within each of the plurality of pixels and a second region located between any two pixels, of the plurality of pixels, adjacent to each other, a transparent insulating layer provided to cover the reflective electrode, and a pixel electrode formed from a transparent conductive material and provided on the transparent insulating layer in each of the plurality of pixels. The second substrate includes a counter electrode provided to be opposite to the pixel electrode and the reflective electrode.

Abstract: A liquid crystal display panel includes pixels including a reflective region for display in a reflection mode and a transmissive region for display in a transmission mode. The liquid crystal display panel includes a liquid crystal layer including a nematic liquid crystal material having negative dielectric anisotropy and a chiral agent, a pixel electrode including a reflective conductive layer and a transparent conductive layer, a counter electrode, a light diffusing structure provided in common to the reflective region and the transmissive region, and a first vertical alignment film provided between the pixel electrode and the liquid crystal layer, and a second vertical alignment film provided between the counter electrode and the liquid crystal layer.